Tumor microenvironment facilitates the emergence of high levels of drug resistance. by Feng Fu (218124)

“…In the absence of drugs, both proliferation and turnover rates of cancer cells decrease with <i>x</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004142#pcbi.1004142.ref022" target="_blank">22</a>]: birth rate <i>β</i>(<i>x</i>) = <i>b</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>) and death rate <i>α</i>(<i>x</i>) = <i>d</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>), where the parameter <i>τ</i>_<i>g</i> is the characteristic length scale of spatial decay in proliferation and turnover rates. …”

RER1 expression significantly reduces αSyn levels. by Hyo-Jin Park (4233949)

Clomiphene citrate effect in obese men with low serum testosterone treated with metformin due to dysmetabolic disorders: A randomized, double-blind, placebo-controlled study by Carla Pelusi (4422919)

“…Compared to baseline levels, T levels increased significantly after 3 months of CC treatment (3.03±0.80 to 5.99±1.67 ng/mL P<0.001) but not after the Plac treatment (2.87±0.78 to 3.09±0.84 ng/mL P<0.001 between the treatments). …”

Effect of H3 haplotype on serum HDL-cholesterol levels in women. by Heidi J. Silver (324097)

“…In obese females, calorically restricted (−15% kcal) HF diet increased HDL-C from 50.11±11.60 mg/dl to 52.29±10.38 mg/dl in H3 haplotype carriers and decreased HDL-C from 47.99±12.90 mg/dl to 45.49±8.95 mg/dl in H3 non-carriers.…”

(a) Western blot of MDA-MB 435 breast cancer cells cultured on fibronectin for 1 hour by Robert F. Klees (62686)

“…Positive control (lane 1) and ethanol control (lane 2) were compared to cells treated with 36 ng/μl of either compound A5, A8, 5, or 9 (lanes 3, 4, 5, and 6, resp) by probing with a monoclonal antibody for Cdc42. …”

IPSE exhibits dose-dependent heptotoxicity that is neutralized by specific monoclonal antibody. by Maha-Hamadien Abdulla (67713)

Effects of synaptic transmission on network bursts. by Davide Lonardoni (4282318)

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

Astrocytic volume changes in the cortex of GFAP/EGFP and GFAP/EGFP/α-Syn^−/− mice during hyperosmotic stress. by Miroslava Anderova (155561)

High-Throughput Screening of Australian Marine Organism Extracts for Bioactive Molecules Affecting the Cellular Storage of Neutral Lipids by James Rae (210551)

“…The activity of heterofibrin A1 was dose dependent with 20 µM inhibiting LD formation and triglyceride accumulation by ∼50% in the presence of 50 µM oleic acid. …”

Hit expansion around chloroxine. by Sam Barker (4832121)

“…This modification causes a significant decrease in this compound’s activity as a co-treatment with ceftazidime, with a <i>p</i>IC50 ≈ 3.4. 5,7-dichloro-2-methyl-8-quinolinol differs from chloroxine by addition of a methyl group in the 2-position (B). …”

Effect of BC-819 on cell growth in different lung cancer cell lines. by Günther Hasenpusch (350166)

“…The influence of BC-819 on bioluminescent A549-C8-luc was examined as well and revealed decreased luciferase and therefore reduced cell growth (more than 50%) as early as after 24 hours (C). …”

Dissociation, and not specific actions of Trypsin-EDTA, acts to suppress neurectoderm formation. by James N. Hughes (319868)

“…Error bars represent sem. (a) denotes a decrease compared to MEDII⁻/Dissociation⁻ where p<0.01. …”

Long-term growth curves of nucleus pulposus chondrocytes (NPCs) obtained from donors of various ages. by Jun-Seok Lee (181420)

“…<p>Plots of cumulative population doubling levels (PDLs) against time in culture (A) and passage number (B). The cumulative PDLs of NPCs from the young group (patients in their 30s, 40s, and 50s) were relatively higher than those from the old group (patients in their 60s and 70s). …”

The reduced expression of ZBRK1 is inversely correlated with the increased expression of KAP1 in cervical cancer specimens. by Li-Fang Lin (449199)

“…<p><b>A</b>, All tumor specimens from 50 patients with different stages of cervical cancer were obtained from surgically resected tissues. …”

Training at maximal power in resisted sprinting: Optimal load determination methodology and pilot results in team sport athletes by Matt R. Cross (5089268)

“…<div><p>Aims</p><p>In the current study we investigated the effects of resisted sprint training on sprinting performance and underlying mechanical parameters (force-velocity-power profile) based on two different training protocols: (i) loads that represented maximum power output (<i>L</i>_opt) and a 50% decrease in maximum unresisted sprinting velocity and (ii) lighter loads that represented a 10% decrease in maximum unresisted sprinting velocity, as drawn from previous research (<i>L</i>₁₀).…”

DataSheet1_Interaction of Serum Alkaline Phosphatase and Folic Acid Treatment on Chronic Kidney Disease Progression in Treated Hypertensive Adults.docx by Yuanyuan Zhang (101797)

“…The primary outcome was CKD progression, defined as a decrease in estimated glomerular filtration rate (eGFR) of ≥30% and to a level of <60 ml/min/1.73 m² if baseline eGFR was ≥60 ml/min/1.73 m²; or a decrease in eGFR of ≥50% if baseline eGFR was <60 ml/min/1.73 m²; or end-stage renal disease. …”

Preclinical mouse model to monitor live Muc5b-producing conjunctival goblet cell density under pharmacological treatments by Céline Portal (3876436)

“…Ten days of BAK in one eye followed by 4 days without any treatment induced a −18.3% decrease in conjunctival goblet cell density. …”

Difference in GHG emissions (<em>x</em>-axis) and food availability (<em>y</em>-axis) in 2050 for the different scenarios with respect to 'TREND' by H Valin (557174)

“…</strong> Difference in GHG emissions (<em>x</em>-axis) and food availability (<em>y</em>-axis) in 2050 for the different scenarios with respect to 'TREND'. Panels (A)–(C) and (D) delineate domains where food provision increases ((A), (B)) or decreases ((C), (D)) and GHG emission savings increase ((B), (D)) or decrease ((A), (C)). …”

Data_Sheet_1_Effect of Lockdown Amid COVID-19 on Ambient Air Quality in 16 Indian Cities.docx by Amit Kumar Mishra (5644676)

“…SO₂ and O₃ showed an increase over a few cities as well as a decrease over the other cities. …”