Image1_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…Subsequently, rats were randomly assigned to a control group (Control), a carbon tetrachloride (CCl₄)-induced hepatic fibrosis model group (Model), a positive control group [0.2 mg/(kg∙day)] of Colchicine), and three TFPCP treatment groups [50, 100, and 150 mg/(kg∙day)]. …”

Image2_Total flavonoids extracted from Penthorum chinense Pursh mitigates CCl4-induced hepatic fibrosis in rats via inactivation of TLR4-MyD88-mediated NF-κB pathways and regulatio... by Sujuan Wang (1865149)

“…Subsequently, rats were randomly assigned to a control group (Control), a carbon tetrachloride (CCl₄)-induced hepatic fibrosis model group (Model), a positive control group [0.2 mg/(kg∙day)] of Colchicine), and three TFPCP treatment groups [50, 100, and 150 mg/(kg∙day)]. …”

Basal PLD activity is strongly stimulated by the D1/5R agonist and blocked by the D1/5R, mGluR5, mGluR1, and the PLD-linked mGluR antagonists in the amygdala of cocaine CPP animals... by Balaji Krishnan (203728)

“…The D1/5R antagonist, SCH23390, completely blocked basal PLD activity (91.2±21.9, n = 12, ^##<i>p</i><0.01) in the cocaine CPP group. A similar reduction in PEtOH levels was observed with application of either the PLD-linked mGluR antagonist, PCCG-13 (62.9±10.6, n = 7, ^##<i>p</i><0.01) or the mGluR1 antagonist, LY367385 (75.0±13.9, n = 12, ^##<i>p</i><0.01), while the mGluR5 antagonist, MPEP, did not decrease basal PLD activity (305.7±31.5, n = 7, ns) within the cocaine CPP group but were significantly increased compared to (*<i>p</i><0.05) the saline treated group. …”

Physiological levels of human MIC-1/GDF15 reduce weight and food intake in mice. by Vicky Wang-Wei Tsai (310159)

Image_2_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.J... by Akimichi Saito (10772010)

“…Ob/ob mice were administered angiotensin II (AngII, 1,000 ng/kg/min) or phosphate-buffered saline (PBS) by osmotic minipumps for 4 weeks and further divided into 2 groups; α-galactosylceramide (αGC; PBS-αGC; n = 5 and AngII-αGC; n = 12), which specifically activates iNKT cells, and PBS (PBS-PBS; n = 10, and AngII-PBS; n = 6). …”

Table_1_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.p... by Akimichi Saito (10772010)

“…Ob/ob mice were administered angiotensin II (AngII, 1,000 ng/kg/min) or phosphate-buffered saline (PBS) by osmotic minipumps for 4 weeks and further divided into 2 groups; α-galactosylceramide (αGC; PBS-αGC; n = 5 and AngII-αGC; n = 12), which specifically activates iNKT cells, and PBS (PBS-PBS; n = 10, and AngII-PBS; n = 6). …”

Image_1_Activation of Invariant Natural Killer T Cells by α-Galactosylceramide Attenuates the Development of Angiotensin II-Mediated Abdominal Aortic Aneurysm in Obese ob/ob Mice.J... by Akimichi Saito (10772010)

“…Ob/ob mice were administered angiotensin II (AngII, 1,000 ng/kg/min) or phosphate-buffered saline (PBS) by osmotic minipumps for 4 weeks and further divided into 2 groups; α-galactosylceramide (αGC; PBS-αGC; n = 5 and AngII-αGC; n = 12), which specifically activates iNKT cells, and PBS (PBS-PBS; n = 10, and AngII-PBS; n = 6). …”

Irisin Ameliorates Hypoxia/Reoxygenation-Induced Injury through Modulation of Histone Deacetylase 4 by Yu Tina Zhao (3359159)

“…HDAC4 overexpression cells and wild type H9c2 cells were exposed to 24 hours of hypoxia followed by one hour of reoxygenation in vitro in the presence or absence of irisin (5 ng/ml). Cell cytotoxicity, apoptosis, mitochondrial respiration, and mitochondrial permeability transition pore (mPTP) were determined. …”

MiR-150 expression promotes myeloid differentiation in AML cell lines. by Valerie A. Morris (462679)

“…(C) THP-1 cells, a MLL-AF9 rearranged monocytic AML cell line, were treated with vehicle control (0.1% DMSO) or TPA (12.5 ng/mL) for 24 hours, or DMSO or ATRA (1 µM) for 48 hours and then assayed. …”

DataSheet_1_Alterations of Cytokine Profiles in Patients With Recurrent Implantation Failure.pdf by Ling Guo (9700)

“…In this prospective study, comprehensive bioinfomatic analysis and logistic regression analysis were used to compare the serum cytokine profiles of 41 RIF patients with those of 29 subjects with first-cycle successful pregnancy in the mid-luteal phase and to assess the alterations of cytokine profiles in patients with clinical pregnancy at five weeks post-transplantation. We found several elevated pro-inflammatory cytokines, decreased anti-inflammatory cytokines, and increased Th1/Th2 cytokine ratios in RIF patients compared to control subjects. …”

Supplementary file 1_Maternal employment patterns after childbirth and child mental health with 4–6 years of age.docx by Deborah Wernecke (22090103)

“…Multivariable linear regression models were employed to examine associations between (1) trajectory classes and (2) maternal employment status at 12 months postpartum with child mental health problems at 4, 5, and 6 years of age.</p>Results<p>We identified five different trajectory classes of maternal employment after childbirth. …”

Cyclic voltammetry and XPS studies of poly (aniline-co-3-aminophenol) by Waware, Umesh Somaji

“…In the electrochemical study, the copolymers differ from PA in the single-electron oxidation and reduction, reversibly at various scan rates ranging from 20 to 50 mV. The current density decreases from PA-co-3-AP20 to PA-co-3-AP80 by increasing the loading weight percentage of 3-aminophenol in the polymeric backbone. …”
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Example results from optimization of procedural parameters. by Mario Roederer (5259)

“…(C) The number of animals required decreases as the target standard error (σ_T) on the final estimate of AID₅₀ decreases (i.e., more precision requires more data). …”

Pattern convergence via scaling in single granule cells. by Antoine D. Madar (6619286)

“…<i>Left and Middle</i>: Mean+/-SEM. Blue indicates a significant difference from the identity line (one-sample t-test, p < 0.05). …”

Data_Sheet_1_Present and future distribution of Faidherbia albida in Cabo Verde as revealed by climatic modelling and LULC analysis.PDF by Danilson Varela (14799583)

“…On average, the predicted suitable habitat for future distributions gradually decreases by 2080 under both scenarios compared with the current, with a smaller effect of RCP4.5 than of RCP8.5. …”

Specific Silencing of the REST Target Genes in Insulin-Secreting Cells Uncovers Their Participation in Beta Cell Survival by David Martin (3178)

“…Using siRNA-mediated knock-down in INS-1E cells, we showed that <em>Cdk5r2</em> protects beta cells against cytokines and palmitate-induced apoptosis. …”

A Meal Detection Algorithm for the Artificial Pancreas: A Randomized Controlled Clinical Trial in Adolescents With Type 1 Diabetes by Emilie Palisaitis (9556686)

“…</a> <p> </p> <p><b>Methods</b>: We conducted a randomized crossover trial in 11 adolescents aged 12-18 years with HbA1c≥7.5% who missed≥1 bolus in the past six months. …”

Aquaporin and red cell O2 permeability by S. Al-Samir (20965502)

“…In addition, the AQP1 inhibitor 5-(phenoxymethyl)furan-2-carbaldehyde) (5-PMFC) decreases human red cell PO2 by ~40%. …”

TMS-Induced Cortical Potentiation during Wakefulness Locally Increases Slow Wave Activity during Sleep by Reto Huber (4023)

“…We show that 5-Hz TMS applied to motor cortex induces a localized potentiation of TMS-evoked cortical EEG responses. …”

Distribution of aquatic macrophytes along depth gradients in Lajeado Reservoir, Tocantins River, Brazil by Ester Vieira Noleto (6379253)

“…Methods Macrophyte sampling occurred at the end of the dry season (September and October 2014) in four sites of the reservoir. We established transects perpendicular to the shoreline, each 25 m long, divided in 3 sections (plots of 5 x 5 m). …”