Identification of RegIV as a Novel GLI1 Target Gene in Human Pancreatic Cancer by Feng Wang (44414)

“…These results were verified for protein (R = 0.939, p = 0.018) and mRNA expression (R = 0.959, p = 0.011) in 5 pancreatic cancer cell lines. RegIV mRNA and protein expression was decreased (94.7±0.3%, 84.1±0.5%; respectively) when GLI1 was knocked down (82.1±3.2%, 76.7±2.2%; respectively) by the RNAi technique. …”

A Randomized Pilot Trial of a Moderate Carbohydrate Diet Compared to a Very Low Carbohydrate Diet in Overweight or Obese Individuals with Type 2 Diabetes Mellitus or Prediabetes by Laura R. Saslow (549629)

“…<div><p>We compared the effects of two diets on glycated hemoglobin (HbA1c) and other health-related outcomes in overweight or obese adults with type 2 diabetes or prediabetes (HbA1c>6%). …”

Table_1_Successful treatment of refractory palmoplantar pustulosis by upadacitinib: report of 28 patients.DOC by Na Du (294594)

“…The mean age was (36.3 ± 10.5) years. After 12 weeks of treatment, PPPASI scores decreased from baseline (13.86 ± 2.76) to (5.56 ± 1.08), with a statistically significant difference (p < 0.05). …”

Presentation_1_Stepwise Development of an in vitro Continuous Fermentation Model for the Murine Caecal Microbiota.pdf by Sophie A. Poeker (6746867)

“…A lower pH during startup and continuous operation stimulated bacterial fermentation (115 mM short-chain fatty acids at pH 7 to 159 mM at pH 6.5). Adjustments to nutritive medium, a decreased pH and increased RT helped control the in vitro Enterobacteriaceae levels, which often bloom in fermentation models, to 6.6 log gene copies/mL in final model. …”

A new strength assessment to evaluate the association between muscle weakness and gait pathology in children with cerebral palsy by Marije Goudriaan (4760493)

“…</p><p>Methods</p><p>Part 1 –Intra- and intertester reliability were determined with the intra-class correlation coefficient (ICC_2,1) in 10 typical developing (TD) children (age: 5–15). We collected MVICs in four lower limb muscle groups to define maximum joint torques, as well as plantar flexor RFD.…”

Table_1_Extreme Hypoxia Causing Brady-Arrythmias During Apnea in Elite Breath-Hold Divers.docx by Thomas Kjeld (5685143)

“…</p><p>Results: During pool apnea of maximum duration (385 ± 70 s), SAT decreased from 99.6 ± 0.5 to 58.5 ± 5.5% (∼PaO₂ 4.8 ± 1.5 kPa, P < 0.001), while Glu increased from 5.8 ± 0.2 to 6.2 ± 0.2 mmol/l (P = 0.009). …”

Data_Sheet_2_Extreme Hypoxia Causing Brady-Arrythmias During Apnea in Elite Breath-Hold Divers.zip by Thomas Kjeld (5685143)

“…</p><p>Results: During pool apnea of maximum duration (385 ± 70 s), SAT decreased from 99.6 ± 0.5 to 58.5 ± 5.5% (∼PaO₂ 4.8 ± 1.5 kPa, P < 0.001), while Glu increased from 5.8 ± 0.2 to 6.2 ± 0.2 mmol/l (P = 0.009). …”

Data_Sheet_1_Extreme Hypoxia Causing Brady-Arrythmias During Apnea in Elite Breath-Hold Divers.zip by Thomas Kjeld (5685143)

“…</p><p>Results: During pool apnea of maximum duration (385 ± 70 s), SAT decreased from 99.6 ± 0.5 to 58.5 ± 5.5% (∼PaO₂ 4.8 ± 1.5 kPa, P < 0.001), while Glu increased from 5.8 ± 0.2 to 6.2 ± 0.2 mmol/l (P = 0.009). …”

Data_Sheet_1_Serum and CSF Metabolites in Stroke-Free Patients Are Associated With Vascular Risk Factors and Cognitive Performance.docx by Sisi Peng (9149948)

“…Seven metabolites (2-aminobutyric acid, Asp Asp Ser, Asp Thr Arg, Ile Cys Arg, 1-methyluric acid, 3-tert-butyladipic acid, and 5α-dihydrotestosterone glucuronide) in serum and three metabolites [Asp His, 13-HOTrE(r), and 2,5-di-tert-Butylhydroquinone] in CSF were significantly increased, and one metabolite (arachidonoyl PAF C-16) in serum was significantly decreased in high-risk group subjects. …”

Effective Reproduction Number, : N95 Respirator. by Samantha M. Tracht (367161)

“…<p>Effective Reproduction Number for N95 respirators. Notice that decreases as a higher percentage of people wear masks as well as when masks are more effective. is greatly reduced when 50% of the population wears masks and masks are 50% effective.…”

Data Sheet 1_Effect of high intakes of protein-only and carbohydrate-only on plasma metabolites and hormones, in addition to nitrogen excretion.xlsx by Matthieu Clauss (9769343)

“…Additionally, we measured urinary nitrogen excretion as a marker of protein degradation.</p>Methods<p>Fourteen young, healthy, moderate-to-well-trained participants (VO_2max 50.6 ± 2.9 mL·kg^-1·min^-1; mean ± SEM) reported in the morning after an overnight fast. …”

<i>Igf-1r</i> hemizygosity has minimal effect on the levels of mutant huntingtin protein. by Silvia Corrochano (618848)

“…Scale bar represents 50 µm. <b>E</b>. Automated quantification of images from D according to aggregate size reveal an increase in the percentage of small-size aggregates (0–0.3 µm²) coupled with a decreased in the percentage of medium-sized aggregates (0.3–0.9 µm²) in HD; <i>Igf-1r^+/−</i> cerebellum compared to controls (p<0.001). …”

S1 Dataset - by Mukhtar A. Ijaiya (16425680)

“…We simulated the predicted prevalence of wasting and overweight as selected SDG-related health inputs and determinant indicators reached their target values. …”

DataSheet1_Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.ZIP by Mengyun Hong (13301475)

“…Experimentally, DSY could efficiently modify expression of signature EndMT genes and decrease expression of PI3K/AKT pathway signals including integrin αV, integrin β1, PI3K, and AKT1 in TGF-β2-treated HUVECs. …”

Image_2_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_7_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Supplementary Material for: Temozolomide Alone or Combined with Capecitabine for the Treatment of Advanced Pancreatic Neuroendocrine Tumor by deMestier L. (6952859)

Image_4_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Image_6_The S2–S3 Loop of Kv7.4 Channels Is Essential for Calmodulin Regulation of Channel Activation.tif by Wenhui Zhuang (10007378)

“…Mutations C156A, C157A, C158V, R159, and R161A, which are located within the Kv7.4 S2–S3 loop, dramatically facilitate activation of Kv7.4 channels co-expressed with WT CaM but have no effect on activation of Kv7.4 channels co-expressed with CaM₃, indicating that these five mutations decrease the inhibitory effect of Ca²⁺/CaM. …”

Data_Sheet_1_ReFerm®: a postbiotic fermented oat gruel composition is reducing mast cell degranulation in the colon of patients with irritable bowel syndrome.PDF by Olga Biskou (6277868)

“…In this study, we investigated the effects of ReFerm^® on regulators of intestinal permeability, namely mast cells and enteric glial cells.…”