Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …”

Hematopoietic-restricted loss of Zeb1 decreases hematopoietic colony formation potential and ability to compete with wt HSPCs for contribution to all hematopoietic lineages. by Jueqiong Wang (11467505)

Longer <i>L</i>_<i>h</i> significantly decreases and delays the peak of the sound-evoked CAPs of SGN fibers. by Maral Budak (6680351)

“…<p>(A) Sound-evoked CAPs of SGN fiber populations of varying heminode length <i>L</i>_<i>h</i> at 70dB SPL, averaged over 50 simulations. …”

Longer <i>L</i>_<i>u</i> significantly decreases and delays the peak of the sound-evoked CAPs of SGN fibers. by Maral Budak (6680351)

“…<p>(A) Sound-evoked CAPs of SGN fiber populations with varying unmyelinated segment length <i>L</i>_<i>u</i> at 70dB SPL, averaged over 50 simulations. …”

Correlation between hub genes and 50 hallmark signaling pathways. by Jiyong Zhang (2498740)

DataSheet_1_Decreased TCF1 and BCL11B expression predicts poor prognosis for patients with chronic lymphocytic leukemia.docx by Taotao Liang (9944552)

“…<p>T cell immune dysfunction is a prominent characteristic of chronic lymphocytic leukemia (CLL) and the main cause of failure for immunotherapy and multi-drug resistance. …”

Sensitivity analysis for IC₅₀ and <i>ε</i>_max as a function of measurement time. by Hope Murphy (8843516)

Effects of 254- and 222-UVC exposure on <i>C</i>. <i>elegans</i> hatching rate. by Kaoru Okamoto Yoshiyama (14526661)

Life expectancy (<i>e</i>_<i>xj</i>) of <i>A</i>. <i>glycines</i>. by Aonan Zhang (8933630)

Life expectancy (<i>e</i>_<i>xj</i>) of <i>A</i>. <i>glycines</i>. by Aonan Zhang (8933630)

The IC50 value of Tan in normal esophageal HET-1A cells. by Dong Yang (141041)

Multiple trauma and hemorrhagic shock induce a transcriptional immune response. by Marc-Alexander Oestreich (13961375)

Pairwise comparisons of hormonal results for DMPA-IM vs NET-EN expressed as mean percentage differences (95% CI) (mITT analysis). by Chanel Avenant (409756)

Host population bottlenecks decrease microbiome diversity. by Michael Ørsted (5926028)

Genes whose expression was decreased by 1 mM ouabain by more than 2-fold. by Larisa V. Smolyaninova (3600053)

Age-stage specific survival rate (<i>s</i>_<i>xj</i>) of <i>A</i>. <i>glycines</i>. by Aonan Zhang (8933630)

Age-stage-specific survival rate (<i>s</i>_<i>xj</i>) of <i>A</i>. <i>glycines</i>. by Aonan Zhang (8933630)

European Credit Transfer System grades (ECTS) (A) and highest educational level (B) according to test scores. by Anders H. Hjulmand (18476019)

Changes in differential chlorophyll fluorescence curves modulated reflection at 820 nm. by Yousra El-Mejjaouy (15877635)