Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …”

Addressing a Trapped High-Energy Water: Design and Synthesis of Highly Potent Pyrimidoindole-Based Glycogen Synthase Kinase-3β Inhibitors by Stanislav Andreev (11067165)

“…Surprisingly, our results demonstrate that this high-energy water was not displaced by our potent inhibitor (<i>S</i>)-3-(3-((7-ethynyl-9<i>H</i>-pyrimido­[4,5-<i>b</i>]­indol-4-yl)­(methyl)­amino)­piperidin-1-yl)­propanenitrile (<b>(<i>S</i>)</b>-<b>15</b>, IC₅₀ value of 6 nM). …”

The forest plot shows the comparison of FA values(A) and ADC values(B) between the stressed and healthy sides in the random effects model. by Nan Wang (21935)

Pairwise comparisons of hormonal results for DMPA-IM vs NET-EN expressed as mean percentage differences (95% CI) (mITT analysis). by Chanel Avenant (409756)

ArxE mice have almost complete loss of α-cell fate by P14 with a concomitant decrease in total endocrine mass, but no change in β- and δ-cell mass. by Crystal L. Wilcox (421799)

hCDC-derived exosomes significantly decrease cardiomyocyte programed cell death and cause a trend toward increased proliferation of cardiomyocytes <i>in vitro</i> at one week in cu... by Jennifer K. Lang (344441)

Predictive values of IC₅₀ in mM (FFAs) for vanadium compounds and <i>in vivo</i> observations IC₅₀ in mM (FFAs) and decreasing blood glucose level. by Elena V. Fedorova (603922)

Top 50 genes whose expression is most decreased in PN11 <i>Klf5</i>CN compared with the WT corneas. by Doreswamy Kenchegowda (135193)

Top 50 genes whose expression is most decreased in PN56 <i>Klf5</i>CN compared with the WT corneas. by Doreswamy Kenchegowda (135193)

Susceptibility of half knockout strains to CYP51 inhibitors (EC50, μM): compounds with decreased activity on HKO + CYP strains. by Laura-Isobel McCall (222498)

Changes in differential chlorophyll fluorescence curves modulated reflection at 820 nm. by Yousra El-Mejjaouy (15877635)

KDM6A mRNA expression is decreased in PTFE mice. by Simon Lebek (9756148)

Decreased peritumoral myofibroblasts in the MC38 S.C. tumors of <i>S100a4-Cre; Ext1</i>^<i>f/f</i> mice. by Ayumi Niwa (6256790)

Changes in differential chlorophyll fluorescence curves modulated reflection at 820 nm. by Yousra El-Mejjaouy (15877635)

Decreasing rates of disorganised attachment in infants and young children, who are at risk of developing, or who already have disorganised attachment. A systematic review and meta-... by Barry Wright (313307)

Plot of mean secondary trauma stress by group and time. by Kunal Desai (18784208)

List of 29 covariates selected from a list of 71 variables using recursive feature elimination and further selection of 17 uncorrelated covariates (shaded grey). by Dennis Ochola (11626912)

Subjects:

Reduced cellular glucose uptake in response to insulin and decreased expression of a mitochondrial ETC complex subunit in <i>ALAS1</i>-knockdown C2C12 myocytes. by Shinichi Saitoh (4794345)

Effect of specific inhibitors on CYP-mediated CK (50 μM) metabolism in HLMs. by Jian Xiao (253329)

Five compounds significantly decrease MAPK1 phosphorylation in K562 cells. by Pamela Y. Ting (713174)