TGF-β1 Exerts Opposing Effects on Grass Carp Leukocytes: Implication in Teleost Immunity, Receptor Signaling and Potential Self-Regulatory Mechanisms by Mu Yang (170922)

“…It is consistent with the observation that TGF-β1 decreased the number of ALK5⁺ leukocytes in PBL and HKL, revealing a negative regulation of TGF-β1 signaling at the receptor level. …”

DataSheet_1_Establishment of Reference Intervals for Thyroid-Associated Hormones Using refineR Algorithm in Chinese Population at High-Altitude Areas.docx by Chaochao Ma (11825525)

“…The RIs for FT3 at Nyingchi, Shigatse/Lhasa, and Ali in females were 4.09–4.98, 4.31–5.45, and 4.82–5.58 pmol/L, while in males, the values were 4.82–5.41, 4.88–5.95, and 5.26–6.06 pmol/L, respectively. …”

Activation of the HH pathway upregulates PDGF. by Zenobia C. Cofer (2580166)

Effect of Salmonella enterica serovar Enteritidis infection on egg production and immune response of the laying duck by Guohong Chen (5590448)

“…Laying rate and egg quality are also decreased after SE infection (<i>P</i><0.05). We further show that SE readily colonizes the stroma, small follicle, isthmus, and vagina in the reproductive tracts of susceptible ducks. …”

Model for grapevine bud cold hardiness and budbreak response: Data files by Amaya Atucha (20927132)

“…Recent studies demonstrate freezing temperatures promote chill accumulation and cold hardiness influences time to budbreak—the phenotype used for dormancy evaluations. Here we evaluated bud cold hardiness and budbreak responses of grapevines (<i>Vitis </i>hybrids) throughout chill accumulation under three treatments: constant (5 °C), fluctuating (−3.5 to 6.5 °C daily), and field conditions (Madison, Wisconsin, USA). …”

Guanylate-binding Protein 1 (Gbp1) Contributes to Cell-autonomous Immunity against <i>Toxoplasma gondii</i> by Elizabeth M. Selleck (407365)

“…Virulent strains of <i>T. gondii</i> avoided recruitment of Gbp1 to the parasitophorous vacuole in a strain-dependent manner that was mediated by the parasite virulence factors ROP18, an active serine/threonine kinase, and the pseudokinase ROP5. Increased recruitment of Gbp1 to Δ<i>rop18</i> or Δ<i>rop5</i> parasites was associated with clearance in IFN-γ-activated macrophages <i>in vitro</i>, a process dependent on the autophagy protein Atg5. …”

Lake sediment record of eolian activity on the eastern Tibetan Plateau since 15 cal ka BP by Xiaohuan Hou (19665160)

“…However, after 3.5 ka a sustained intensification of eolian activity occurred in the Gahai area, which was linked to decreasing vegetation cover, reduced regional humidity, and growing human impacts, especially in the eastern plateau, in southern Gansu. …”

Defects in tRNA Modification Associated with Neurological and Developmental Dysfunctions in <em>Caenorhabditis elegans</em> Elongator Mutants by Changchun Chen (139128)

“…However, how Elongator functions in metazoans, and how the human mutations affect neural functions is incompletely understood. Here we show that in <em>Caenorhabditis elegans</em>, ELPC-1 and ELPC-3, components of the Elongator complex, are required for the formation of the 5-carbamoylmethyl and 5-methylcarboxymethyl side chains of wobble uridines in tRNA. …”

Representation and kinetics of conservative oscillators based on motif 2 and motif 5. by Kristian Thorsen (631743)

“…Initial concentrations: , . At time t = 50.0 is changed from 1.0 to 3.0. (c) , , and frequency as a function of the perturbation . …”

ASN2 inhibits viral RNA synthesis. by Mila Brum Ortigoza (168874)

“…(B) Primer extension analysis of influenza virus mRNA and vRNA from A549 cells infected with influenza A/WSN/33 virus (MOI = 5) and treated with DMSO or decreasing concentrations of ASN2 (50–12.5 µM) for 6 hours. …”

DNMT inhibition induced cellular senescence. by Ah-Young So (221707)

Data_Sheet_1_Climate and Human-Driven Variability of Summer Hypoxia on a Large River-Dominated Shelf as Revealed by a Hypoxia Index.docx by Kui Wang (137551)

“…Multiple linear regression showed that the HI significantly correlated with three direct hypoxia drivers including water column stratification, subsurface water residence time, and respiration rates, which accounted for 5.7, 55.3, and 34.5%, respectively, of the total variance of PCA derived HI. …”

Table 1_Intravenous fosphenytoin therapy for the rescue of acute trigeminal neuralgia crisis in pre- and post-neurosurgical patients: a retrospective observational study.docx by Shusaku Noro (20516450)

“…Fosphenytoin diluted with physiological saline was administered intravenously at a loading dose of 9.8–20.7 mg/kg or at a dose of 7.5–9.5 mg/kg when maintenance therapy was needed. …”

DNA hypermethylation of Fgf16 and Tbx22 associated with cleft palate during palatal fusion by Xuan Shu (7475837)

“…This study aimed to explore the potential role of DNA methylation in the mechanism of CP. Methodology: We established an all-trans retinoic acid (ATRA)-induced CP model in C57BL/6J mice and used methylation-dependent restriction enzymes (MethylRAD, FspEI) combined with high-throughput sequencing (HiSeq X Ten) to compare genome-wide DNA methylation profiles of embryonic mouse palatal tissues, between embryos from ATRA-treated vs. untreated mice, at embryonic gestation day 14.5 (E14.5) (n=3 per group). …”

Image_2_HPV Induces Changes in Innate Immune and Adhesion Molecule Markers in Cervical Mucosa With Potential Impact on HIV Infection.pdf by Alan Messala A. Britto (6209393)

“…HPV infected patients expressed higher levels of TLR9 and lower levels of pattern recognition receptors that recognize RNA (TLR3, TLR7, and MDA5/IFIH1). We also detected an impaired IFN pathway, with an increased Type I IFN and a decreased IFNα2 receptor expression. …”

Function and Evolution of DNA Methylation in <i>Nasonia vitripennis</i> by Xu Wang (28596)

“…<div><p>The parasitoid wasp <i>Nasonia vitripennis</i> is an emerging genetic model for functional analysis of DNA methylation. Here, we characterize genome-wide methylation at a base-pair resolution, and compare these results to gene expression across five developmental stages and to methylation patterns reported in other insects. …”

Leukemia Inhibitory Factor Protects Axons in Experimental Autoimmune Encephalomyelitis via an Oligodendrocyte-Independent Mechanism by Melissa M. Gresle (126963)

“…These mice also showed increased axonal damage relative to LIF heterozygous mice, as indicated by decreased optic nerve parallel diffusivity on MRI (1540±207 µm²−/s vs 1310±175 µm²−/s; P&lt;0.05), and optic nerve (−12.5%) and spinal cord (−16%) axon densities; and increased serum neurofilament-H levels (2.5 fold increase). …”

Table 1_Association of inflammatory biomarkers with new functional morbidity at hospital discharge in children who survive severe sepsis.docx by Mallory A. Perry-Eaddy (20842868)

“…</p>Results<p>New functional morbidity occurred in 38 children (32%) and was associated with increased plasma levels of interleukin (IL)-6, IL-18, sIL-2Ra, MCP1, IL-8 (CXCL8), sIL-1RII, IL-10, MIP1a, and IL-2r and decreased RANTES (CCL5) (p < .001) at all three timepoints. …”

Supplementary Material for: Calcium-citrate anticoagulation during continuous renal replacement therapy in patients with metformin intoxication: a case series, mathematical estimat... by Brunoni B. (16876404)

“…The T/I calcium ratio was consistently below 2.5, and SIG decreased, reaching values lower than 6 mEq/L after 48h of CVVH treatment. …”

Amphiphobic Polytetrafluoroethylene Membranes for Efficient Organic Aerosol Removal by Shasha Feng (2573317)

“…We use atomic-layer deposition (ALD) to uniformly coat a layer of nanosized ZnO particles onto porous PTFE matrix to increase surface area and then subsequently graft PFDAE with plasma. …”