Tamoxifen-Induced Epigenetic Silencing of Oestrogen-Regulated Genes in Anti-Hormone Resistant Breast Cancer by Andrew Stone (107521)

“…One such gene candidate, growth differentiation factor 15 (GDF15), was carried forward for functional analysis. The addition of 5-Aza/E2 was sufficient to de-methylate and activate GDF15 expression in the tamoxifen resistant cell-lines, whilst in parallel, treatment with recombinant GDF15 protein decreased cell survival. …”

Limited detection of small (≤ 10 mm) colorectal liver metastasis at preoperative CT in patients undergoing liver resection by Yousun Ko (4688230)

“…</p><p>Results</p><p>Fourteen nodule sizes were missing in the pathology report. Nodules of 1–5 mm and 6–10 mm accounted for 8.1% (n = 36) and 23.5% (n = 105) of the remaining 447 nodules, and the number of nodules gradually decreased as nodule size increased beyond 10 mm. …”

Data_Sheet_1_Differential Impact of Dietary Branched Chain and Aromatic Amino Acids on Chronic Kidney Disease Progression in Rats.pdf by Samyuktha Muralidharan Pillai (8102531)

“…The present study aimed at identifying potential differences between amino acid (AA) groups constituting dietary proteins regarding their impact on RPF, GFR, and CKD progression. We utilized the well-established 5/6 nephrectomy (5/6 Nx) CKD model in rats and submitted the animals for 5 weeks to either the control diet (18% casein protein) or to diets containing 8% casein supplemented with 10% of a mix of free amino acids, representing all or only a subset of the amino acids contained in casein. …”

4-PBA alleviates ER stress in dystonia models. by Jin A. Cho (656426)

“…We have not observed significant differences in sliced XBP1 (sXBP1) levels, an ER stress marker, upon 4-PBA treatments (2.5 and 5 mM) in healthy control or DYT1 fibroblast cells. …”

Table 1_Impact of hearing loss on brain signal variability in older adults under different auditory load conditions.docx by Songjian Wang (18173353)

“…In contrast, we found that hearing loss reduced brain signal variability during speech recognition tasks, especially in noisy conditions, in the mild hearing loss and moderate to severe hearing loss groups, possibly indicating decreased neural processing efficiency. …”

DataSheet_1_Trends in radiotherapy administration in the management of hepatocellular carcinoma: Analysis of a Korean tertiary hospital registry of hepatocellular carcinoma patient... by Bong Kyung Bae (8736945)

“…With the technical developments, the overall survival (OS) of patients who received radiotherapy as initial management increased significantly (5-year OS: from 5.4% to 30.1%), and the OS difference between patients who did and did not receive radiotherapy as initial management significantly decreased (ratio of restricted mean survival time: from 0.383 to 0.544).…”

Data Sheet 1_Increased risk of deep vein thrombosis, pulmonary embolism, and all-cause mortality in chronic venous disorder: a large-scale retrospective cohort study.docx by Eva Lotta Moderegger (22389298)

“…Comparing CVD patients with interventions to those without, the risk of DVT (0.9, 0.8–0.9), PE (0.6, 0.5–0.6) and all-cause mortality (0.5, 0.5–0.5) decreased. …”

Image_2_Trends in radiotherapy administration in the management of hepatocellular carcinoma: Analysis of a Korean tertiary hospital registry of hepatocellular carcinoma patients di... by Bong Kyung Bae (8736945)

“…With the technical developments, the overall survival (OS) of patients who received radiotherapy as initial management increased significantly (5-year OS: from 5.4% to 30.1%), and the OS difference between patients who did and did not receive radiotherapy as initial management significantly decreased (ratio of restricted mean survival time: from 0.383 to 0.544).…”

Dehalogenation of Polybrominated Diphenyl Ethers and Polychlorinated Biphenyls Catalyzed by a Reductive Dehalogenase in Dehalococcoides mccartyi Strain MB by Guofang Xu (10292543)

“…The PCE-pregrown cultures of strain MB debrominated 86.6 ± 7.4% penta-BDEs to di- to tetra-BDEs within 5 days. Similarly, extensive dechlorination of Aroclor1260 and Aroclor1254 was observed in the PCE-pregrown cultures of strain MB, with the average chlorine per PCB decreasing from 6.40 ± 0.02 and 5.40 ± 0.03 to 5.98 ± 0.11 and 5.19 ± 0.07 within 14 days, respectively; <i>para</i>-substituents were preferentially dechlorinated from PCBs. …”

Image_3_CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.JPEG by Tanwir Hashem (8825765)

“…Interestingly, Il13 but not Il4 or Il5 gene expression in the lungs was dramatically decreased in HDME-exposed Cd2^−/− mice. …”

Data_Sheet_1_The role of GPD1L, a sodium channel interacting gene, in the pathogenesis of Brugada Syndrome.PDF by Alexander M. Greiner (18852223)

“…</p>Objective<p>We sought to re-assess the genetic underpinnings of BrS in a large mutligenerational family with a putative mutation in GPD1L that affects surface membrane expression of Na_V1.5 in vitro.…”

Micelle and Inverse Micelle Structure Driven Viscoelasticity and Phase Separation in 2‑Isobutoxyethanol–Water Mixtures: Insights from All-Atom Simulations by Mayank Dixit (7879364)

“…We observed the presence of the inverse micelle structure in <i>x</i>_IBE = 0.5 and micelle structures in <i>x</i>_IBE = 0.1. …”

Data Sheet 1_Co-administration of vitamin D and N-acetylcysteine to modulate immunosenescence in older adults with vitamin D deficiency: a randomized clinical trial.pdf by Samira Rastgoo (15252703)

“…</p>Results<p>After the intervention, supplementation with D5N and D5 significantly downregulated p16, interleukin-6 (IL-6), and tumor necrosis factor-α (TNF-α) expression and decreased SA-β-gal activity compared to the D1 group. …”

Data_Sheet_1_Beyond QuantiFERON-TB Results, the Added Value of a Weak Mitogen Response.pdf by Marine Jacquier (578627)

“…</p>Methods<p>Retrospective, case-control study in hospitalized patients who underwent QFT testing in two hospitals between 2016 and 2019. We defined two groups of cases with either negative [interferon (IFN)-γ ≤ 0.5 IU/ml, official threshold] or weak (0.5–2 IU/ml) mitogen response, and one group of controls with normal (>2 IU/ml) mitogen response.…”

Image_1_Trends in radiotherapy administration in the management of hepatocellular carcinoma: Analysis of a Korean tertiary hospital registry of hepatocellular carcinoma patients di... by Bong Kyung Bae (8736945)

“…With the technical developments, the overall survival (OS) of patients who received radiotherapy as initial management increased significantly (5-year OS: from 5.4% to 30.1%), and the OS difference between patients who did and did not receive radiotherapy as initial management significantly decreased (ratio of restricted mean survival time: from 0.383 to 0.544).…”

Data_Sheet_1_High blood viscosity in acute ischemic stroke.PDF by Jihoon Kang (816884)

“…At an oscillatory frequency of 10 rad/sec, blood viscosity differed significantly between the ischemic stroke (24.2 ± 4.9 centipoise, cP) and stroke mimic groups (17.8 ± 6.5 cP, p < 0.001). This finding was consistent at different oscillatory frequencies (134.2 ± 46.3 vs. 102.4 ± 47.2 at 1 rad/sec and 39.2 ± 11.5 vs. 30.4 ± 12.4 at 5 rad/sec, Ps < 0.001), suggesting a relationship between decreases in viscosity and shear rate. …”

Image_1_The Predictive Value of Estrogen Receptor 1 on Adjuvant Chemotherapy in Locally Advanced Colorectal Cancer: A Retrospective Analysis With Independent Validation and Its Pot... by Shu-Biao Ye (4264795)

“…Downregulation of ESR1 was related with enhanced chemosensitivity to 5-FU in CRC cell lines, while upregulation of ESR1 was correlated with decreased chemosensitivity.…”

Table_1_After-Effects of Thixotropic Maneuvers on Chest Wall and Compartmental Operational Volumes of Healthy Subjects Using Optoelectronic Plethysmography.DOCX by Illia Nadinne Dantas Florentino Lima (7617188)

“…Thus, after performing thixotropic maneuvers, OEP may also provide evidence regarding the history-dependent properties of these muscles. We studied the after-effects of different thixotropic conditionings on chest wall (CW) and compartmental operational volumes of 28 healthy subjects (25.5 ± 2.2 years, FVC_%pred 94.8 ± 5.5, and FEV₁_%pred 95.5 ± 8.9) using OEP. …”

Image_2_CD2 Regulates Pathogenesis of Asthma Induced by House Dust Mice Extract.JPEG by Tanwir Hashem (8825765)

“…Interestingly, Il13 but not Il4 or Il5 gene expression in the lungs was dramatically decreased in HDME-exposed Cd2^−/− mice. …”

Neuronal stiffening upon exposure to veratridine. by Shan Zou (452518)

“…The Young’s modulus of a neuron exposed to 50 µM veratridine decreased to below the initial value. …”