Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

Synthesis, Evaluation, and Mechanism Study of Novel Indole-Chalcone Derivatives Exerting Effective Antitumor Activity Through Microtubule Destabilization in Vitro and in Vivo by Jun Yan (28467)

“…Among them, <b>14k</b> exhibited most potent activity, with IC₅₀ values of 3–9 nM against six cancer cells, which displayed a 3.8–8.7-fold increase in activity when compare with compound <b>2</b>. …”

<i>C</i>. <i>sinensis</i> enhanced bile duct and liver injury through TLR2 pathway. by Yuru Wang (846969)

Effect of high-intensity interval training on glycemic control in adults with type 1 diabetes with overweight or obesity: a randomized controlled trial with partial cross-over by Angela S Lee (8996732)

“…In participants who undertook at least 50% of the prescribed HIIT intervention, the HbA1c reduction was significantly greater than control (HIIT -0.64 ± 0.64% (n=9), control -0.14 ± 0.48% (n=15), p=0.04). …”

Superposition of conserved PARG1 C1-RhoGAP domains bound to RhoA protein. by Zen Kouchi (14898435)

Stereospecific CO₂ Copolymers from 3,5-Dioxaepoxides: Crystallization and Functionallization by Ye Liu (296340)

“…As a model monomer of 3,5-dioxa-epoxides, 4,4-dimethyl-3,5,8-trioxabicyclo[5.1.0]­octane (CXO) was studied in detail in the asymmetric copolymerization with CO₂. …”

Proteome and Metabolome Profiling of Anticoagulant Disorders Induced by Familial Protein S Deficiency by Caiping Zhang (6745976)

Effect of AP5 on mitral cell responses measured by 2-photon Ca²⁺ imaging. by Rico Tabor (74133)

“…Black and white arrows show mitral cells whose response was increased and decreased, respectively, by AP5 treatment. (B) Average somatic Ca²⁺ signals before (control) and during application of AP5, normalized to control. …”

Endoscopic injection into the vocal fold muscle. by Ikuo Mikoshiba (9312007)

Behavior in baseline sessions. by R. Becket Ebitz (7841318)

Result of whole-mount <i>in situ</i> hybridization at 48 hpf. by Yali Ge (417371)

Change of colocalization of Sig1R-YFP and KDEL-mRFP caused by (+)-pentazocine. by Sergei Kopanchuk (6406085)

“…The first data point on the x axis (0 min) indicates baseline measurement (Control). …”

(A, B) Western blot analysis of lysates from the two clones with the TrkB-BAC minigene (77−5 and 77−6) before and after deglycosylation and probed with an antibody recognizing TrkB... by Francesco Tomassoni-Ardori (22216521)

Hidden Markov model (HMM) design and fit to behavior. by R. Becket Ebitz (7841318)

Predicting a Stable Dimeric Form of the PD1-PDL1 Complex: Implications for Understanding the PD1 Activation Mechanism by Luis F. Ponce (2795155)

PPM1A facilitates both nuclear distribution and transcription potency of YAP/TAZ. by Ruyuan Zhou (10197187)

“…<b>(B–D)</b> Transcription potency of YAP (5 ng), which was suppressed by coexpression of MST1 (50 ng) (B), LATS1 (500 ng) (C), or MAP4K1 (50 ng) (D), was markedly recovered by cotransfection of wild-type PPM1A but not the enzyme-dead PPM1A (D239N). …”

Results from the multi-resolution decomposition of daily precipitation fields based on 2-D Haar wavelet transform (blue 1961–1990, pink 1991–2020). by Rasmus E. Benestad (12530330)

Inhibition of FleA by 2EHex or fucose results in a loss of mucin binding and greatly reduced phagocytosis by macrophages. by Sheena C. Kerr (495450)

“…<p>(A) Structures of fucopyranoside compounds. (B) Amount of compound required to inhibit binding of labeled FleA to mucin by 50% (IC50 [μM]). …”

The spot coupling analysis. by Sergei Kopanchuk (6406085)

ERAD defects and the HFE-H63D variant are associated with increased risk of liver damages in Alpha 1-Antitrypsin Deficiency by Philippe Joly (3161052)

“…Finally, these findings support a larger scale screening for HERPUD1 R50H and HFE H63D variants in the sub-group of 1ATD patients developing significant chronic hepatic injuries (hepatomegaly, chronic cholestasis, elevated liver enzymes) and at risk developing liver cirrhosis.…”