The small molecule Scaff10-8 inhibits the interaction of the DH domain of AKAP-Lbc and RhoA. by Katharina Schrade (4801266)

“…(B) In the HTRF from (A), Scaff10-8 inhibited the interaction of AKAP-Lbc/DHPH and RhoA with an IC₅₀ = 34.1 μM whereas Scaff10-59 did not (example of a negative Scaff10 derivative). …”

Mass spectrum of 7-MH. by Juthamart Maneenet (15999769)

“…This study evaluated the anti-cancer potential of 7-methoxyheptaphylline (7-MH), a carbazole alkaloid from <i><i>Clausena harmandiana</i></i>, against pancreatic cancer cells (PANC-1) and developed an environmentally sustainable extraction methodology using ultrasonic-assisted extraction (UAE). 7-MH demonstrated selective cytotoxicity against PANC-1 cells with preferential activity under nutrient deprivation conditions (PC₅₀ = 4.54 μM) compared to nutrient-rich conditions (IC₅₀ = 46.84 μM). …”

ANOVA for 7-MH yield. by Juthamart Maneenet (15999769)

“…This study evaluated the anti-cancer potential of 7-methoxyheptaphylline (7-MH), a carbazole alkaloid from <i><i>Clausena harmandiana</i></i>, against pancreatic cancer cells (PANC-1) and developed an environmentally sustainable extraction methodology using ultrasonic-assisted extraction (UAE). 7-MH demonstrated selective cytotoxicity against PANC-1 cells with preferential activity under nutrient deprivation conditions (PC₅₀ = 4.54 μM) compared to nutrient-rich conditions (IC₅₀ = 46.84 μM). …”

Raw images of Western blot experiment. by Juthamart Maneenet (15999769)

“…This study evaluated the anti-cancer potential of 7-methoxyheptaphylline (7-MH), a carbazole alkaloid from <i><i>Clausena harmandiana</i></i>, against pancreatic cancer cells (PANC-1) and developed an environmentally sustainable extraction methodology using ultrasonic-assisted extraction (UAE). 7-MH demonstrated selective cytotoxicity against PANC-1 cells with preferential activity under nutrient deprivation conditions (PC₅₀ = 4.54 μM) compared to nutrient-rich conditions (IC₅₀ = 46.84 μM). …”

Expression of PerRA and PerRB in <i>L</i>. <i>interrogans</i> wild-type and mutant strains. by André A. Grassmann (11141592)

Image_3_IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model.TIF by Mona Sohrabi (9082586)

Image_1_IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model.TIF by Mona Sohrabi (9082586)

Image_2_IGF-1R Inhibitor Ameliorates Neuroinflammation in an Alzheimer’s Disease Transgenic Mouse Model.TIF by Mona Sohrabi (9082586)

Results of simulations for “naïve” approach. by K. Alexandra Curtis (231254)

“…<p>Results from base and trial simulations, for population growth under management based on “naïve” approach to local limit reference point (LRP) estimation. Population outcomes are presented in terms of abundance of adults relative to that at <i>N</i>_MNP for a stable age distribution. …”

Distinct Roles for the vBcl-2-mediated Inhibition of Autophagy and Apoptosis in γHV68 Chronic Infections In Vivo. by Xiaofei E (82852)

“…At 28 dpi (D), 35 dpi (E), and 42 dpi (F), the decreased infectious center titers (top) of vBcl-2 mutant viruses, as compared to WT γHV68, were statistically significant [vBcl-2Δα1 versus vBcl-2AAA (42 dpi), <i>P</i> = 0.46; vBcl-2Δα1 versus WT γHV68 (42 dpi), <i>P</i> = 0.08; unpaired <i>t</i>-tests]. …”

Variation law of AE events rate of sandstone under different freeze-thaw cycles at a loading rate of 0.05 mm/min. by Wenyu Lv (20139458)

Variation law of AE events rate of sandstone under different freeze-thaw cycles at a loading rate of 0.05 mm/min. by Wenyu Lv (20139458)

<i>Plasmodium</i> infectivity at day-time vs night time. by Tibebu Habtewold (91734)

Native albumin antioxidant response to stress produced by short-wave UV light. by Rafael Medina-Navarro (253862)

“…In stressed conditions at above12.5 µg, the AC could not be produced exclusively from the Cys34 SH and intermediates, and there is a loss of linearity; the point at which the Response Surplus is produced.…”

Climate complexity in the migratory cycle of <i>Ammodramus bairdii</i> by Alexander Peña-Peniche (5687786)

“…A continuous and alarming decrease of its populations has been observed over the last 50 years, and studying its seasonal distribution and associated climatic niches could help improve strategies for its conservation. …”

Ambient Air Pollutant Dynamics (2010–2025) and the Exceptional Winter 2016–17 Pollution Episode: Implications for a Uranium/Arsenic Exposure Event by Thomas Clemens Carmine (19756929)

“…Figshare; 2024. doi:10.6084/m9.figshare.27435639.v5</li><li>Carmine TC. Reconstructed Zurich Air Pollution Data (2015–2019) with Lag Structure for Urinary Metal Toxicokinetic Analysis [Dataset]. …”

miR-27a protects human mitral valve interstitial cell from TNF-α-induced inflammatory injury via up-regulation of NELL-1 by Honglei Chen (125181)

Vitamin A deficiency indicating as low expression of LRAT may be a novel biomarker of primary hypertension by Xiaohua Liang (535684)

“…<p>Vitamin A (VA) deficiency triggers many diseases and is a worldwide nutrition problem. …”

Early reduction in total cholesterol to high-density lipoprotein cholesterol ratio predicts hydroxychloroquine efficacy in treating IgA nephropathy by Yaotong Shi (19511899)

“…</p> <p>Patients in the high TC/HDL-C decline rate group with ≥50% decrease in proteinuria from baseline experienced a significant improvement during the follow-up. …”

Data_Sheet_1_The Virulence of Escherichia coli O157:H7 Isolates in Mice Depends on Shiga Toxin Type 2a (Stx2a)-Induction and High Levels of Stx2a in Stool.docx by Jocelyn R. Hauser (8493432)

“…The stx_2a+ isolate was avirulent. Both an stx_2a and a recA deletion mutant of one of the stx_2a+stx_2c+ strains, JH2010, exhibited at least a three-log decrease in cytotoxicity in vitro and both were avirulent in the mice. …”