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a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
point decrease » point increase (Expand Search)
nn decrease » _ decrease (Expand Search), gy decreased (Expand Search), b1 decreased (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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9401
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9402
Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators
Published 2022“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”
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9403
Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators
Published 2022“…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”
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9404
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9405
Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact...
Published 2023“…Coadministration of itraconazole increased the AUC<sub>0-inf</sub> of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”
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9406
Smoking impact on fibrosis and cancer gene expression.
Published 2017“…Even at this low magnification the increased dysplasia of the bronchial lining is visible (asterisks). Bar = 50 microns. B. Plots show the relative expression of selected pro-fibrotic genes in the α7<sup>G</sup> or the α7<sup>E260A:G</sup> and the relative impact of either LPS (from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.ref007" target="_blank">7</a>]) or CS (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.t002" target="_blank">Table 2</a>). …”
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9407
Changes to distal lung structure of both α7 genotypes with and without CS exposure.
Published 2017“…In these representative sections the arrows point to AMs and in the α7<sup>E260A:G</sup> arrow heads identify regions of increased cellularity that produce alveolar sacs of decreased size. …”
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9408
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9409
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9410
Experimental Demonstration That GDF11 Regulates <i>p</i><sub>1</sub> and <i>v</i><sub>1</sub>
Published 2009“…NCAM immunofluorescence (green) is shown in (A–C); BrdU immunofluorescence (red) in (D–F); merged images in (G–I). Arrowheads point to examples of BrdU<sup>+</sup>/NCAM<sup>−</sup> cells; arrows point to examples of BrdU<sup>+</sup>/NCAM<sup>+</sup> cells.…”
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9411
Scores of each variable in the main components.
Published 2023“…Stellate sturgeon (<i>Acipenser stellatus</i>) fry, was exposed to diazinon (25, 50, and 75% of 96h-LC<sub>50</sub>) for 6 days after pre-treatment with an HSP inducer (HSPi), TEX-OE<sup>®</sup> (a prickly pear cactus extract), for 4 hours. …”
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9412
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9413
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9414
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9415
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9416
Data_Sheet_1_High Level of SARS-CoV-2 Infection in Young Population Is a Predictor for Peak Incidence.PDF
Published 2022“…This suggested that the number of confirmed cases had an influence on the fatality rate as a quantitative parameter. The fatality rate decreased even as infection with SARS-CoV-2 variants rose. …”
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9417
Fig 1 -
Published 2023“…<p>Top 50 drugs with (A) greatest percentage increase and (B) greatest percentage decrease in average spending per beneficiary between 2014 and 2020.…”
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9418
Fig 3 -
Published 2023“…<p>Percentage change in beneficiaries for the top 50 drugs with (A) greatest increase and (B) greatest decrease in average spending per beneficiary between 2014 and 2020.…”
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9419
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9420
Data_Sheet_1_Evidence of Cross-Cultural Consistency of the S-Five Model for Misophonia: Psychometric Conclusions Emerging From the Mandarin Version.docx
Published 2022“…The S-Five was translated in a forward-backward method to Mandarin to establish a satisfactory translation. …”