Showing 9,401 - 9,420 results of 35,226 for search '(( 50 ((mean decrease) OR (a decrease)) ) OR ( 5 ((point decrease) OR (nn decrease)) ))', query time: 1.42s Refine Results
  1. 9401
  2. 9402

    Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

    Published 2022
    “…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”
  3. 9403

    Structure–Activity Studies of 1<i>H</i>‑Imidazo[4,5‑<i>c</i>]quinolin-4-amine Derivatives as A<sub>3</sub> Adenosine Receptor Positive Allosteric Modulators by Lucas B. Fallot (14106171)

    Published 2022
    “…Although having low Caco-2 permeability and high plasma protein binding, hydrophobic 2-cyclohept-4-enyl-<i>N</i>-3,4-dichlorophenyl, MRS7788 <b>18</b>, and 2-heptan-4-yl-<i>N</i>-4-iodophenyl, MRS8054 <b>39</b>, derivatives were orally bioavailable in rat. 2-Heptan-4-yl-<i>N</i>-3,4-dichlorophenyl <b>14</b> and 2-cyclononyl-<i>N</i>-3,4-dichlorophenyl <b>20</b> derivatives and <b>39</b> greatly enhanced Cl-IB-MECA-stimulated [<sup>35</sup>S]GTPγS binding <i>E</i><sub>max</sub>, with only <b>12b</b> trending toward decreasing the agonist EC<sub>50</sub>. A feasible route for radio-iodination at the <i>p-</i>position of a 4-phenylamino substituent suggests a potential radioligand for allosteric site binding. …”
  4. 9404
  5. 9405

    Phase 1 study to evaluate the effects of rifampin or itraconazole on the pharmacokinetics of limertinib (ASK120067), a novel mutant-selective inhibitor of the epidermal growth fact... by Bei Cao (141848)

    Published 2023
    “…Coadministration of itraconazole increased the AUC<sub>0-inf</sub> of limertinib by 289.8% (GLSM ratio, 389.8%; 90% CI, 334.07–454.82), but decreased that of CCB4580030 by 35.96% (GLSM ratio, 64.04%; 90% CI, 50.78–80.77).…”
  6. 9406

    Smoking impact on fibrosis and cancer gene expression. by Lorise C. Gahring (271630)

    Published 2017
    “…Even at this low magnification the increased dysplasia of the bronchial lining is visible (asterisks). Bar = 50 microns. B. Plots show the relative expression of selected pro-fibrotic genes in the α7<sup>G</sup> or the α7<sup>E260A:G</sup> and the relative impact of either LPS (from [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.ref007" target="_blank">7</a>]) or CS (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0187773#pone.0187773.t002" target="_blank">Table 2</a>). …”
  7. 9407

    Changes to distal lung structure of both α7 genotypes with and without CS exposure. by Lorise C. Gahring (271630)

    Published 2017
    “…In these representative sections the arrows point to AMs and in the α7<sup>E260A:G</sup> arrow heads identify regions of increased cellularity that produce alveolar sacs of decreased size. …”
  8. 9408
  9. 9409
  10. 9410

    Experimental Demonstration That GDF11 Regulates <i>p</i><sub>1</sub> and <i>v</i><sub>1</sub> by Arthur D Lander (82004)

    Published 2009
    “…NCAM immunofluorescence (green) is shown in (A–C); BrdU immunofluorescence (red) in (D–F); merged images in (G–I). Arrowheads point to examples of BrdU<sup>+</sup>/NCAM<sup>−</sup> cells; arrows point to examples of BrdU<sup>+</sup>/NCAM<sup>+</sup> cells.…”
  11. 9411

    Scores of each variable in the main components. by Leila Vahdatiraad (17382718)

    Published 2023
    “…Stellate sturgeon (<i>Acipenser stellatus</i>) fry, was exposed to diazinon (25, 50, and 75% of 96h-LC<sub>50</sub>) for 6 days after pre-treatment with an HSP inducer (HSPi), TEX-OE<sup>®</sup> (a prickly pear cactus extract), for 4 hours. …”
  12. 9412
  13. 9413
  14. 9414
  15. 9415
  16. 9416

    Data_Sheet_1_High Level of SARS-CoV-2 Infection in Young Population Is a Predictor for Peak Incidence.PDF by Haeyoun Choi (11001667)

    Published 2022
    “…This suggested that the number of confirmed cases had an influence on the fatality rate as a quantitative parameter. The fatality rate decreased even as infection with SARS-CoV-2 variants rose. …”
  17. 9417

    Fig 1 - by Benazir Hodzic-Santor (14593183)

    Published 2023
    “…<p>Top 50 drugs with (A) greatest percentage increase and (B) greatest percentage decrease in average spending per beneficiary between 2014 and 2020.…”
  18. 9418

    Fig 3 - by Benazir Hodzic-Santor (14593183)

    Published 2023
    “…<p>Percentage change in beneficiaries for the top 50 drugs with (A) greatest increase and (B) greatest decrease in average spending per beneficiary between 2014 and 2020.…”
  19. 9419
  20. 9420

    Data_Sheet_1_Evidence of Cross-Cultural Consistency of the S-Five Model for Misophonia: Psychometric Conclusions Emerging From the Mandarin Version.docx by Silia Vitoratou (5825897)

    Published 2022
    “…The S-Five was translated in a forward-backward method to Mandarin to establish a satisfactory translation. …”