Development of the Nb474H/IgM8A2-B “hybrid” sandwich ELISA prototype. by Steven Odongo (2143756)

“…A high signal intensity (OD_450nm) observed at higher concentrations of IgM8A2-B tapered with the decreasing concentrations of the mAb indicating that Strep-HRP was binding coated IgM8A2-B. …”

The Number of Patients and Events Required to Limit the Risk of Overestimation of Intervention Effects in Meta-Analysis—A Simulation Study by Kristian Thorlund (149383)

“…<div><h3>Background</h3><p>Meta-analyses including a limited number of patients and events are prone to yield overestimated intervention effect estimates. …”

Nutritional Support for Patients Sustaining Traumatic Brain Injury: A Systematic Review and Meta-Analysis of Prospective Studies by Xiang Wang (127867)

“…Small-bowel feeding was found to be with a decreasing rate of pneumonia compared with nasogastric feeding (RR = 0.41; 95% CI, 0.22–0.76).…”

An Early-Onset Subgroup of Type 2 Diabetes: A Multi-Generational, Prospective Analysis in the Framingham Heart Study by Justin B. Echouffo-Tcheugui (9388233)

“…In second-generation participants, having a parent with early-onset diabetes increased diabetes risk by 3.24-fold (1.73-6.07) whereas having one or both parents with late-onset diabetes increased diabetes risk by 2.19-fold (1.50-3.19).…”

Image_1_Effects of Perioperative Dexmedetomidine on Immunomodulation in Uterine Cancer Surgery: A Randomized, Controlled Trial.tif by Jin Sun Cho (11710808)

“…Objective<p>Dexmedetomidine has sympatholytic, anti-inflammatory, and analgesic effects and may exert anti-tumor effect by acting on α2A adrenoreceptor. We investigated whether perioperative dexmedetomidine preserves immune function in patients undergoing uterine cancer surgery.…”

DataSheet1_A novel hybrid bioprocess strategy addressing key challenges of advanced biomanufacturing.PDF by Lucas Nik Reger (14632742)

“…The novel process showed increased productivity (+217%) as well as longer cultivation duration, in comparison to a standard FB with a significantly lower media consumption per produced product (−50%) and a decreased need for process monitoring, in comparison to a perfusion cultivation. …”

Ageing increases Arctic Aβ42 peptide accumulation and toxicity when transcript levels are equalised at different ages. by Iain Rogers (152860)

“…<p>UAS-Arctic Aβ42/+; elavGS/+ females were pulsed, for 1 week, either at 2 or 5 days old with 50 µM RU (RU 50 [2–9d] or [5–12d]) or 20 days old with 200 µM RU (RU 200 [20–27d]). …”

Datasheet1_Fever management in children and insights into fever of unknown origin: a survey among Italian pediatricians.pdf by Elena Chiappini (304802)

Data Sheet 1_Cytomegalovirus infection in infants with biliary atresia in China: a multi-center investigation study.docx by Yilin Zhao (487866)

“…</p>Conclusion<p>Among the 1,276 infants with BA in this cohort, 31.3% (399 cases) had concomitant CMV infection, representing a decrease compared to previous data. CMV-IgM played a crucial role in the detection of the infection. …”

Image_1_TnP Peptide Suppresses Experimental Autoimmune Encephalomyelitis (EAE) in a Preclinical Mouse Model.pdf by Carla Lima (428557)

“…We have shown that TnP possesses a disease suppressive function in EAE, ameliorating disease severity by 40% and suppressing the accumulation of T helper (Th)1- and Th17-producing lymphocytes (by 55% and 60%, respectively) in CNS along with activated microglia/macrophages populations (by 33% and 50%, respectively), and also conferred a protective effect anticipating the remyelination process to day 66 compared to day 83 of untreated cuprizone-mice. …”

Video_3_Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.MP4 by Lise Heylen (11561266)

Video_2_Pericardial Injection of Kainic Acid Induces a Chronic Epileptic State in Larval Zebrafish.MP4 by Lise Heylen (11561266)

Hydroxysafflor Yellow A Ameliorates Renal Fibrosis by Suppressing TGF-β1-Induced Epithelial-to-Mesenchymal Transition by Naping Hu (2614399)

“…The aim of this study was to investigate whether Hydroxysafflor yellow A (HSYA) can preserve renal function by inhibiting the progression of renal fibrosis and the potential mechanisms.…”

Table_1_Evolving a New Efficient Mode of Fructose Utilization for Improved Bioproduction in Corynebacterium glutamicum.DOCX by Irene Krahn (10888566)

“…This is known to result in a significantly reduced oxidative pentose phosphate pathway (oxPPP) flux on fructose (∼10%) compared to glucose (∼60%). …”

Table_1_Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.xlsx by Jun Tang (32983)

“…The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). …”

Table_3_Causal association of gut microbiota on spondyloarthritis and its subtypes: a Mendelian randomization analysis.xlsx by Jun Tang (32983)

“…The family Rikenellaceae id.967 was associated with a reduced risk of both AS (OR = 0.66 (95% CI: 0.47–0.93); p = 1.81E−02) and psoriatic arthritis (OR = 0.70 (95% CI: 0.50–0.97); p = 3.00E−02). …”

Data_Sheet_1_Biocontrol Potential of a Novel Endophytic Bacterium From Mulberry (Morus) Tree.docx by Sen Xie (8349420)

“…Moreover, when applied to the generalist herbivore Spodoptera litura, ZJU1 was sufficient to reduce the pest survival rate below 50%. A previously undiscovered crystal toxin (Cry10Aa) could contribute to this insecticidal effect against notorious lepidopteran pests. …”

<i>Toxoplasma gondii</i> serine-protease inhibitor-1: A new adjuvant candidate for asthma therapy by Ariadna S. Soto (4538035)

“…This effect was accompanied by a lung resistance reduction of 26.3% and 50.3% respectively. …”

<i>fahd-1(tm5005) C</i>. <i>elegans</i> have a locomotion deficit. by Andrea Taferner (782532)

“…(B) 4-day old wild type and <i>fahd-1(tm5005)</i> worms were put in the center of an NGM plate seeded with <i>E</i>. <i>coli</i> OP50. The radial dispersal rate (see <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0134161#sec002" target="_blank">Materials and Methods</a>) was determined for three different time points (30 sec, 1 min, 2 min). …”

Substrate-Dependent Inhibition of the Human Organic Cation Transporter OCT2: A Comparison of Metformin with Experimental Substrates by Kristina Hacker (773425)

“…<div><p>The importance of the organic cation transporter OCT2 in the renal excretion of cationic drugs raises the possibility of drug-drug interactions (DDIs) in which an inhibitor (perpetrator) drug decreases OCT2-dependent renal clearance of a victim (substrate) drug. …”