Pacritinib effectively decreases BTIC viability and sphere forming capacity and has on-target activity on phospho-STAT3. by Katharine Victoria Jensen (4691530)

“…<p>(A) Pacritinib dramatically decreased cell viability in a dose dependent manner in eleven molecularly diverse patient-derived BTIC cultures with IC₅₀ values from 0.62 μM to 1.66 μM. …”

TSA administration decreases neuromuscular junction loss in <i>Smn^2B/-</i> mice. by Hong Liu (50694)

“…Note that whilst there is widespread NMJ pathology in vehicle treated mice, as evidence by full/partial denervation (white arrowhead/arrow respectively), NF accumulation (yellow arrow) and small, immature post-synaptic endplates, NMJs appear much more healthy in TSA treated mice, as evidenced by a decrease in denervation and NF accumulation, and an increase in post-synaptic size and maturity (scale bar = 50 µm). …”

Image_1_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.tif by Kanako Iwasaki (16451151)

“…Decreased senescence and improved insulin-secretory function of β-cells were also evident when the βIgf1rKD mice were fed a high-fat diet (HFD; 60% kcal from fat, for 5 weeks).…”

Table_1_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.docx by Kanako Iwasaki (16451151)

“…Decreased senescence and improved insulin-secretory function of β-cells were also evident when the βIgf1rKD mice were fed a high-fat diet (HFD; 60% kcal from fat, for 5 weeks).…”

Image_3_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.tif by Kanako Iwasaki (16451151)

“…Decreased senescence and improved insulin-secretory function of β-cells were also evident when the βIgf1rKD mice were fed a high-fat diet (HFD; 60% kcal from fat, for 5 weeks).…”

Image_2_Decreased IGF1R attenuates senescence and improves function in pancreatic β-cells.tif by Kanako Iwasaki (16451151)

“…Decreased senescence and improved insulin-secretory function of β-cells were also evident when the βIgf1rKD mice were fed a high-fat diet (HFD; 60% kcal from fat, for 5 weeks).…”

Chronic Arachidonic Acid Administration Decreases Docosahexaenoic Acid- and Eicosapentaenoic Acid-Derived Metabolites in Kidneys of Aged Rats by Masanori Katakura (816112)

“…In addition, levels of free-form ARA, prostaglandin E₂, and 12- and 15-hydroxyeicosatetraenoic acid increased in the ARA-administered group, whereas renal concentration of docosahexaenoic acid and eicosapentaenoic acid decreased in the ARA-administered group. Levels of docosahexaenoic acid-derived protectin D1, eicosapentaenoic acid-derived 5-, and 18-hydroxyeicosapentaenoic acids, and resolvin E2 and E3 decreased in the ARA-administered group. …”

RNS60 treatment of tMCAo mice decreased microglial activation in the CA3 region of the ipsilateral hippocampus. by Gloria Patricia Baena-Caldas (17721328)

VPA treated prostate cancer cells show decreased repair capacity and γ-H2AX clearance. by Sushant K. Kachhap (273170)

Decreased platelet responsiveness to clopidogrel correlates with CYP2C19 and PON1 polymorphisms in atherosclerotic patients by J.F.M. Marchini (6515189)

ETHE1-p.Arg163Gln and p.Arg163Trp are folded but have decreased stability. by Bárbara J. Henriques (627180)

Data_Sheet_1_Decreased RNA polymerase III subunit expression leads to defects in oligodendrocyte development.docx by Julia Macintosh (15350707)

“…Analysis of Pol III transcriptional activity revealed a decrease in the expression of distinct tRNAs, which was significant in the siPolr3a condition.…”

Glu induces GABA release (A) Glu uptake decreases cytosolic GABA level as determined by [³H]GABA release from NPMV vesicles preloaded with [³H]GABA (n = 3).... by László Héja (370338)

Inhibition of ALK4/5/7 decreases Sertoli cell proliferation in E12.5 fetal testes. by Denise C. Miles (218867)

Decreasing Abundance, Increasing Diversity and Changing Structure of the Wild Bee Community (Hymenoptera: Anthophila) along an Urbanization Gradient by Laura Fortel (614514)

“…The abundance of wild bees was negatively correlated with the proportion of impervious surface, while species richness reached a maximum at an intermediate (50%) proportion of impervious surface. …”

Decreasing the expression of <i>OsVTC1-1</i> impairs the tolerance of rice seedlings to salt stress. by Hua Qin (461262)

TcMTH and EcMutT parasites effectively decreased DHR oxidation and show increase in antioxidant enzyme expression. by Grazielle R. Goes (2585713)

CK1δ-specific kinase activity in HT1080 cells is decreased after activation of Chk1. by Joachim Bischof (189845)

Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV‑2 Main Protease by Julia M. Flynn (16475720)

“…Drugs that target the main protease (M^pro) of SARS-CoV-2 are effective therapeutics that have entered clinical use. …”

Systematic Analyses of the Resistance Potential of Drugs Targeting SARS-CoV‑2 Main Protease by Julia M. Flynn (16475720)

“…Drugs that target the main protease (M^pro) of SARS-CoV-2 are effective therapeutics that have entered clinical use. …”