Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Structure-Based Design, Synthesis, and Biological Evaluation of New Triazolo[1,5‑<i>a</i>]Pyrimidine Derivatives as Highly Potent and Orally Active ABCB1 Modulators by Shuai Wang (109515)

“…In this work, we reported the structure-based design of triazolo­[1,5-<i>a</i>]­pyrimidines as new ABCB1 modulators, of which <b>WS-691</b> significantly increased sensitization of ABCB1-overexpressed SW620/Ad300 cells to paclitaxel (PTX) (IC₅₀ = 22.02 nM). …”

Data_Sheet_5_Telomere length and the risk of cardiovascular diseases: A Mendelian randomization study.PDF by Yingjian Deng (13999767)

“…</p>Materials and methods<p>In this two-sample MR study, we identified 154 independent TL-associated genetic variants from a genome-wide association study (GWAS) consisting of 472,174 individuals (aged 40–69) in the UK Biobank. …”

K⁺-leak channels enhance the growth of pectoral fin buds. by Xiaowen Jiang (8291814)

SCD1 dynamics are altered in response to RSV. by Cristina Rojas (667363)

Image_5_C5a/C5aR1 Pathway Is Critical for the Pathogenesis of Psoriasis.JPEG by Quan-you Zheng (713217)

“…The lack of characterization of the pathogenesis of psoriasis has hindered efficient clinical treatment of the disease. In our study, we observed that expression of complement component 5a receptor 1(C5aR1) was significantly increased in skin lesions of both imiquimod (IMQ) and IL23-induced psoriatic mice and patients with psoriasis. …”

Infection parameters of Swiss mice infected with 50,000 trypomastigotes of the Y strain of <i>T</i>. <i>cruzi</i>. by Camila França Campos (360935)

“…(B) The mortality rate until the 20^th d.a.i. was significantly high, with death of approximately 50% of the animals treated with benznidazole. …”

Overexpression of TNFAIP9 remitted the renal inflammation caused by 5/6 Nx in C57 mice. by Ying Chen (9697)

Kaplan-Meier curves for the effect of VD₃ sufficiency vs. deficiency on survival of mice from BCR-ABL Arf-/- leukemia. by Kavya Annu (11587215)

Confocal planes of FLIM-FRET images in fin buds at different developmental time points. by Xiaowen Jiang (8291814)

An Analysis of Porphyrin Molecular FlexibilityUse of Porphyrin Diacids by Beisong Cheng (2970567)

“…Molecular mechanics calculations, using a modified version of MM2(87) and a newly developed force field for porphyrin diacids, correctly predict that the flexibility of <i>meso</i>-tetraaryl porphyrin diacids decreases as the steric bulk of the peripheral substituents increases:  [H₄TPyP]²⁺ ≈ [H₄TPP]²⁺ > [H₄T-2,6-(OH)₂ PP]²⁺ ≈ [H₄T-2,6-F₂ PP]²⁺ > [H₄T-2,6-Cl₂ PP]²⁺ ≈ [H₄TMP]²⁺. …”

Graph illustrating correlation between right CIMT and TBI (A) and ABI (B). by Gisoo Darban Hosseini Amirkhiz (10974784)

DataSheet1_Are the 50 m Race Segments Changed From Heats to Finals at the 2021 European Swimming Championships?.PDF by Raúl Arellano (13036584)

“…Specifically, combining men and women, the swimmers had in freestyle a mean coefficient of variation (CV) of ∼0.6%, with a mean range of performance improvement (∆%) of ∆ = ∼0.7%; in breaststroke a mean CV of ∼0.5% and ∆ = −0.2%; in backstroke a mean CV of ∼0.5% and ∆ = −0.6%, and; in butterfly a mean CV of ∼0.7% and ∆ = −0.9%. …”

DataSheet2_Are the 50 m Race Segments Changed From Heats to Finals at the 2021 European Swimming Championships?.pdf by Raúl Arellano (13036584)

“…Specifically, combining men and women, the swimmers had in freestyle a mean coefficient of variation (CV) of ∼0.6%, with a mean range of performance improvement (∆%) of ∆ = ∼0.7%; in breaststroke a mean CV of ∼0.5% and ∆ = −0.2%; in backstroke a mean CV of ∼0.5% and ∆ = −0.6%, and; in butterfly a mean CV of ∼0.7% and ∆ = −0.9%. …”

Illustration of our hypothesis that the older subjects may show a decreased δ-θ phase locking index (H1) or β amplitude (H2) since the variability of the motor performance increase... by Liqing Liu (4570171)

FLIM-FRET measurements with KIRIN1 sensor detects relative changes in intracellular K⁺. by Xiaowen Jiang (8291814)

“…<b>(Ab)</b> FLIM-FRET measurements of the KIRIN1 sensor expressed in the same cells that were patched in Aa detected decreases in intracellular K⁺ in cells expressing CMV:<i>kcnk5b</i>-mCherry (blue) compared to cells lacking the expression of the channel (CMV:mCherry, red). …”

Treatment adoption and diffusion pattern. by Frédéric Galacteros (11105678)

“…The model also projected life expectancy to increase by 15.8%, and incident cases of stroke, pulmonary hypertension, and chronic kidney disease to decrease by 19.8%, 24.5%, and 25.1%, respectively. …”

Effects of nuclear hormone treatments on <i>kcnk5b</i>, <i>rcan2</i>, and control genes in pectoral fin buds and adult fins and sufficiency/necessity experiments for <i>rcan2</i>. by Xiaowen Jiang (8291814)

Proportion of travel modes used and collision counterparts for different types of road vehicle collision as a suicide method between 2001 and 2017 in Australia. by Phillip C. F. Law (18468738)