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we decrease » _ decrease (Expand Search), teer decrease (Expand Search), use decreased (Expand Search)
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a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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12981
Table_5_Network analyses of upper and lower airway transcriptomes identify shared mechanisms among children with recurrent wheezing and school-age asthma.xlsx
Published 2023“…Based on network analysis of nasal and tracheal transcriptomes, we aimed to identify convergent transcriptomic mechanisms in RW and SA.…”
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12982
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12983
Data_Sheet_1_Risk stratification and prediction of severity of COVID-19 infection in patients with preexisting cardiovascular disease.CSV
Published 2024“…</p>Methods<p>We collected blood samples and clinical data from hospitalized cardiovascular patients with and without proven COVID-19 infection in the time period before the vaccine became available. …”
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12984
Presentation_1_Risk stratification and prediction of severity of COVID-19 infection in patients with preexisting cardiovascular disease.PDF
Published 2024“…</p>Methods<p>We collected blood samples and clinical data from hospitalized cardiovascular patients with and without proven COVID-19 infection in the time period before the vaccine became available. …”
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12985
An Allosteric Modulator of RNA Binding Targeting the N‑Terminal Domain of TDP-43 Yields Neuroprotective Properties
Published 2020“…<i>In silico</i> docking of 50K compounds to the NTD domain of TDP-43 identified a small molecule (nTRD22) that is bound to the N-terminal domain. …”
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12986
The number of amyloid plaques and amount of Aβ<sub>1-42</sub> were reduced in S100A9 KO/Tg mice.
Published 2014“…Sections are 4 µm thick. ((a) – (h) Scale bar; 200 µm, (i)-(l) scale bar; 50 µm). …”
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12987
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12988
The conserved phenylalanine residue in PRMT5 is critical for inhibition by the five compounds.
Published 2017“…D, The F225M mutation in PRMT5 decreased the IC<sub>50</sub> values of the compounds, as determined by quantitation and analysis of methylation assay results.…”
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12989
Antimicrobial activity of RP-1 peptide conjugate with ferrocene group
Published 2020“…In comparison with amphotericin B, a second-line drug approved for leishmaniasis treatment, (IC<sub>50</sub> = 0.63 μmol L<sup>-1</sup>), Fc-RP1 was more active and showed a 2.5-fold higher selectivity index. …”
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12990
Acute Hypersensitivity of Pluripotent Testicular Cancer-Derived Embryonal Carcinoma to Low-Dose 5-Aza Deoxycytidine Is Associated with Global DNA Damage-Associated p53 Activation,...
Published 2012“…We show here that low-dose 5-aza treatment results in DNA damage and induction of p53 in NT2/D1 cells. …”
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12991
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12992
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12993
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12994
Identification of novel pathogenic mutations in <i>ATP6V0A4</i> associated with distal renal tubular acidosis and analysis of wild-type expression in glomerular disease
Published 2025“…We identified novel <i>ATP6V0A4</i> mutations (c.2219C > T, c.197-1G > C, and c.2293_c.2296del AGCG) and confirmed their pathogenicity using bioinformatics and <i>in vitro</i> experiments. …”
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12995
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo
Published 2024“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC<sub>50</sub> = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”
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12996
Discovery, Synthesis, and Activity Evaluation of Novel Five-Membered Sulfur-Containing Heterocyclic Nucleosides as Potential Anticancer Agents In Vitro and In Vivo
Published 2024“…Among them, compound <b>22o</b> exhibited remarkable antiproliferative activity against HeLa cells and was more potent than cisplatin (IC<sub>50</sub> = 2.80 vs 7.99 μM). Furthermore, mechanism studies indicated that <b>22o</b> inhibited cell metastasis, induced cell apoptosis, decreased mitochondrial membrane potential, and activated autophagy through the PI3K-Akt-mTOR signaling pathway. …”
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12997
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12998
Enhanced Rice Blast Resistance by CRISPR/Cas9-Targeted Mutagenesis of the ERF Transcription Factor Gene <i>OsERF922</i>
Published 2016“…Here, we report the improvement of rice blast resistance by engineering a CRISPR/Cas9 SSN (C-ERF922) targeting the <i>OsERF922</i> gene in rice. …”
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12999
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13000