Showing 5,641 - 5,660 results of 60,547 for search '(( 50 ((mean decrease) OR (a decrease)) ) OR ( 5 ((we decrease) OR (teer decrease)) ))', query time: 0.86s Refine Results
  1. 5641
  2. 5642
  3. 5643
  4. 5644
  5. 5645
  6. 5646

    Reduction of the mean absolute error (MAE) in time for all participant on x-axis. by Almoctar Hassoumi (6470354)

    Published 2019
    “…<p>A similar effect is observed for y-axis. The MAE obtained using the standard regression (orange circles) decreased significantly when using symbolic regression. …”
  7. 5647
  8. 5648
  9. 5649

    Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

    Published 2022
    “…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC<sub>50</sub> at 2.1 μM. …”
  10. 5650

    Discovery of Betulinic Acid Derivatives as Potent Intestinal Farnesoid X Receptor Antagonists to Ameliorate Nonalcoholic Steatohepatitis by Chenlu Zhang (508309)

    Published 2022
    “…Evidence showed that intestinal FXR antagonism exhibited remarkable metabolic improvements in mice. Herein, we developed a series of betulinic acid derivatives as potent intestinal FXR antagonists, and <b>F6</b> was identified as the most potent one with an IC<sub>50</sub> at 2.1 μM. …”
  11. 5651

    Image_3_Decrease of GSK-3β Activity in the Anterior Cingulate Cortex of Shank3b−/− Mice Contributes to Synaptic and Social Deficiency.TIF by Mengmeng Wang (540017)

    Published 2019
    “…From 4 weeks post-birth, neurons in Shank3b<sup>−/−</sup> ACC exhibited an obvious decrease in spine density and stubby spines. The length and thickness of post-synaptic density (PSD), the expression of vesicular glutamate transporter 2 (vGlut2) and glutamate receptor 2 (GluR2), and the frequency of miniature excitatory post-synaptic currents (mEPSCs) were significantly reduced in Shank3b<sup>−/−</sup>ACC. …”
  12. 5652

    Image_1_Decrease of GSK-3β Activity in the Anterior Cingulate Cortex of Shank3b−/− Mice Contributes to Synaptic and Social Deficiency.tif by Mengmeng Wang (540017)

    Published 2019
    “…From 4 weeks post-birth, neurons in Shank3b<sup>−/−</sup> ACC exhibited an obvious decrease in spine density and stubby spines. The length and thickness of post-synaptic density (PSD), the expression of vesicular glutamate transporter 2 (vGlut2) and glutamate receptor 2 (GluR2), and the frequency of miniature excitatory post-synaptic currents (mEPSCs) were significantly reduced in Shank3b<sup>−/−</sup>ACC. …”
  13. 5653

    Image_4_Decrease of GSK-3β Activity in the Anterior Cingulate Cortex of Shank3b−/− Mice Contributes to Synaptic and Social Deficiency.TIF by Mengmeng Wang (540017)

    Published 2019
    “…From 4 weeks post-birth, neurons in Shank3b<sup>−/−</sup> ACC exhibited an obvious decrease in spine density and stubby spines. The length and thickness of post-synaptic density (PSD), the expression of vesicular glutamate transporter 2 (vGlut2) and glutamate receptor 2 (GluR2), and the frequency of miniature excitatory post-synaptic currents (mEPSCs) were significantly reduced in Shank3b<sup>−/−</sup>ACC. …”
  14. 5654

    Image_2_Decrease of GSK-3β Activity in the Anterior Cingulate Cortex of Shank3b−/− Mice Contributes to Synaptic and Social Deficiency.TIF by Mengmeng Wang (540017)

    Published 2019
    “…From 4 weeks post-birth, neurons in Shank3b<sup>−/−</sup> ACC exhibited an obvious decrease in spine density and stubby spines. The length and thickness of post-synaptic density (PSD), the expression of vesicular glutamate transporter 2 (vGlut2) and glutamate receptor 2 (GluR2), and the frequency of miniature excitatory post-synaptic currents (mEPSCs) were significantly reduced in Shank3b<sup>−/−</sup>ACC. …”
  15. 5655

    Discovery of Urea Derivatives of Celastrol as Selective Peroxiredoxin 1 Inhibitors against Colorectal Cancer Cells by Yang Li (7082)

    Published 2024
    “…Herein, a series of celastrol urea derivatives were developed based on its cocrystal structure with PRDX1, with the aim of pursuing a PRDX1-specific inhibitor. …”
  16. 5656

    Identification, Synthesis, and Biological Evaluations of Potent Inhibitors Targeting Type I Protein Arginine Methyltransferases by Xiao Li (107004)

    Published 2022
    “…Compared to the type I PRMT inhibitor from our previous work (DCPR049_12), ZL-28-6 showed increased potency against CARM1 and decreased activity against other type I PRMTs. Moreover, ZL-28-6 showed better antiproliferation activities toward a series of solid tumor cells than DCPR049_12, indicating its broad spectrum of anticancer activity. …”
  17. 5657
  18. 5658
  19. 5659
  20. 5660