Identification of Chalcones as <i>Fasciola hepatica</i> Cathepsin L Inhibitors Using a Comprehensive Experimental and Computational Approach by Florencia Ferraro (3146766)

“…One of the compounds, <b>C34</b>, tightly bounds to juvenile specific <i>Fh</i>CL3 with an IC₅₀ of 5.6 μM. We demonstrated that <b>C34</b> is a slow-reversible inhibitor that interacts with the Cys-His catalytic dyad and key S₂ and S₃ pocket residues, determinants of the substrate specificity of this family of cysteine proteases. …”

Interventions to improve antiretroviral therapy adherence among adolescents in low- and middle-income countries: A systematic review of the literature by Kathleen Ridgeway (4479478)

“…Moreover, HIV-related mortality increased by 50% between 2005 and 2012 for adolescents 10–19 years while it decreased by 30% for all other age groups. …”

IGF-1 downregulates MMP8 and reduces collagenase activity in cultured THP-1 macrophages. by Patricia Snarski (22305205)

Fig 18 - by Wei Li (7081)

Fig 16 - by Wei Li (7081)

Variable attributes. by Zhendong Sun (4723221)

Supplementary file 1_Practical utility of meropenem therapeutic drug monitoring: a systematic review of evidence for clinical application.docx by Yi-Chang Zhao (14080107)

Data_Sheet_4_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Data_Sheet_1_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Data_Sheet_3_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOCX by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Data_Sheet_2_Immune-Inflammatory Parameters in COVID-19 Cases: A Systematic Review and Meta-Analysis.DOC by Xudong Feng (1426792)

“…Furthermore, we found that NLR, as a novel marker of systemic inflammatory response, can also help predict clinical severity in patients with COVID-19 (OR = 2.50, 95% CI: 2.04–3.06).…”

Capillaries are depicted more clearly with extension (IST_7.6, IST_12.0, and IST₂₀) of the interscan time; OCTA images of the healthy macular area in... by Masaharu Ishikura (4338823)

ZC3H18 regulates NF-kB components independently of LMP1. by Huanzhou Xu (8129922)

Representative μCT image slice of the femoral cortical mid-diaphysis (thresholded). by Daksh Arora (16510065)

Serum Metabolic Signatures Induced By a Three-Day Intensified Exercise Period Persist After 14 h of Recovery in Runners by David C. Nieman (322662)

“…Immediately following the 3-day exercise period, significant 2-fold or higher increases in 75 metabolites were measured, with all but 22 of these metabolites related to lipid/carnitine metabolism, 13 to amino acid/peptide metabolism, 4 to hemoglobin/porphyrin metabolism, and 3 to Krebs cycle intermediates (<i>q</i>-values < 0.001). After a 14 h overnight recovery period, 50 of the 75 metabolites remained elevated, with 8 decreased (primarily amino acid-related metabolites) (<i>q</i>-values < 0.05). …”

Supplementary Material for: Comparison of Insulin, Metformin, and Glyburide on Perinatal Complications of Gestational Diabetes Mellitus: A Systematic Review and Meta-Analysis by Wang X. (2828795)

“…<b><i>Conclusions:</i></b> This review suggests that metformin can decrease the incidence of perinatal complications, and it should be considered as a generally safe alternative to insulin.…”

Table_7_Depletion of tet2 results in age-dependent changes in DNA methylation and gene expression in a zebrafish model of myelodysplastic syndrome.xlsx by Yaseswini Neelamraju (4509259)

“…The gene encoding ten-eleven translocation 2 (tet2), a dioxygenase enzyme that catalyzes the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine, is a recurrently mutated tumor suppressor gene in MDS and other myeloid malignancies. …”

The health care utilization of people in prison and after prison release: A population-based cohort study in Ontario, Canada by Fiona G. Kouyoumdjian (489495)

“…<div><p>Background</p><p>Many people experience imprisonment each year, and this population bears a disproportionate burden of morbidity and mortality. …”

SH3KBP1 enhances K63-linked polyubiquitination of RIG-I. by Jiaoyang Li (2862269)

Data Sheet 1_Efficacy and safety of hydroxyurea therapy on patients with β-thalassemia: a systematic review and meta-analysis.pdf by Tianmin Huang (20561477)

“…HU, in transfusion-dependent β-thalassemia patients, was related to a significant decrease in transfusion requirements [a pooled RR of 0.37 and a pooled good RR of 0.65 (95% CI, 0.53–0.76)]; in transfusion-independent β-thalassemia patients, it was correlated to an excellent raise in Hb levels [a pooled RR of 0.20 (95% CI, 0.08–0.35) and a pooled good RR of 0.53 (95% CI, 0.41–0.65)]. …”