siRNAs targeting IDH1. by Xi Chen (35903)

“…Two good siRNAs (-G-) and three bad siRNAs (-B-) are designed to target the IDH1 gene; all of them decrease the target gene expression by about 50%. (B–E) The relative expression levels of off-target genes predicted by Picky. …”

SIRT1 regulates the maintenance of the dendritic tree. by Juan F. Codocedo (304388)

“…Neurons were fixed at 14 DIV and immunostained against Tau protein. (<b>A</b>) Representative images of Tau immunodetection in trasfected GFP positive neurons. …”

Laccase-catalyzed iodination of different mono-methoxy-substituted phenolic compounds (structures: see Figure 2). by Julian Ihssen (417694)

“…a<p>Reaction conditions: 4 mM educt, 50 mM potassium iodide, 100 µM ABTS and 0.25 mg mL⁻¹<i>T. versicolor</i> laccase, % conversion was calculated as the relative decrease in educt peak area compared to enzyme-free control reactions.…”

Assessment of vascular density with CD31 labeling. by Deepa Sharma (278210)

“…Scale bar: 50 μm. (B) Quantification of vascularity from whole tumour sections measured from high magnification microscopy indicates a decrease in vascularity with combined treatment (570 kPa, 40 min) when compared with heat alone 0 kPa, 40 min (n = 3–5). …”

Effect of miR155 on the expression of target genes. by Cui Lei (110562)

“…Treating miR155-overexpressing cells with EGF resulted in a further decrease of SMAD2. No significant changes in TCF4 or CMYC mRNA were observed between EGF-treated and miR155 mimic-transfected cells. …”

Normal occlusion in maturational life process by Daniela GARIB (12682165)

“…Objective: In this article, the occlusal and facial aging changes occurred during almost 50 years of follow-up are described. A normal occlusion sample from Bauru Dental School, University of São Paulo, Brazil, was evaluated at 13 (T1), 17 (T2) and 60 (T3) years of age. …”

Medication-overuse headache. Retrospective comparison of preventive treatments by Abouch V. Krymchantowski (5187023)

“…Sudden withdrawal and pharmacological prevention with one or more drugs were carried out. Adherence and the decrease of headache frequency of more than 50% were compared after four months between the one or two, three, and four drug groups. …”

Live-cell imaging of cAMP in Flamindo2/nlsFlamindo2-expressing COS7 cells. by Haruki Odaka (575909)

“…<p>(A) Representative images showing changes in fluorescence intensity (FI) by 50 µM forskolin application in Flamindo2-expressing COS7 cells. …”

Changes of perceived unevenness caused by in-track vibration countermeasures in slab track by Verachtert, R.

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Geographic distribution of random forest model predictions of Spotted and Eastern towhee species identity. by Ximena León Du’Mottuchi (21560805)

“…<b>(B)</b> The same results from <b>(A)</b> are plotted based on the percent of trees in the random forest classifier that supported the correct species identification; when less than 50% of trees supported the correct identification, the classifier made an incorrect species prediction. …”

The β2AR Pathway Involves PI3K/AKT in Controlling Keratinocyte Migration by Raja K Sivamani (587219)

“…Error bars represent standard error of the mean, <i>n =</i> 4; <i>* p <</i> 0.05.</p> <p>(B) Keratinocyte migration was measured after exposure to either procaterol (10 nM), ICI-118,551 (20 μM, specific β2AR antagonist), procaterol with ICI-118,551, LY294002 (50 μM, PI3K inhibitor), or LY294002 (50 μM) with ICI-118,551 (20 μM). …”

General effects of training. by Marieke van der Linden (268336)

BBR increases autophagic activity in cultured cells. by Wenxiao Jiang (777255)

“…<p><b>(A)</b> Western blotting of LC3B in HEK293 cells transfected with or without Htt and treated with BBR (0, 5, 25, 50, or 100 μM). …”

The attenuating effects of Msi1 knockdown on Hh signaling in MSC proliferation and apoptosis. by In-Sun Hong (284033)

“…Purmorphamine increased cell proliferation (<b>A</b>) and decreased TUNEL-positive cell numbers (<b>B</b>), while the 50 nM Msi1 siRNA transfection produced the opposite effects. …”

Neither motor nor sensory axon loss in <i>Nmf249/+</i> mice is abated by transgenes A or D. by William W. Motley (194151)

“…There is an obvious clustering of WT, WT; <i>TgA</i>, and WT; <i>TgD</i> mice and <i>Nmf249/+, Nmf249/+</i>; <i>TgA</i>, and <i>Nmf249/+</i>; <i>TgD</i> mice.…”

Time-resolved UV-visible spectroscopy of bodipy-based materials by F Cucinotta (7836197)

“…The first set of materials is characterised by green luminescence that, as the dye loading increases from 1% to 50%, shows a decrease in quantum yields from 0.22 to 0.05 and a reduction of the excited state lifetime. …”

Igf signaling is required for cardiomyocyte proliferation during zebrafish heart development. by Ying Huang (53474)

“…E. A significant decrease (***<i>p</i><0.0001) in cardiomyocyte proliferation was detected in embryos treated with NVP-AEW541.…”

Synthesis and bioactivity of the γ-secretase modulator photo-probe AR243. by Thorsten Jumpertz (188948)

“…AR243 caused a dose-dependent decrease in Aβ42 levels with a concomitant increase in Aβ38 levels, confirming its bioactivity as a potent GSM with an IC₅₀ for Aβ42 reduction of 290 nM.…”

Abnormal social communication and mounting in Katnal2-KO mice. by Ryeonghwa Kang (6793046)

“…Two-way ANOVA encompassing all behaviors did not reveal a genotype-related difference. (<i>n</i> = 12 [WT], 14 [KO], two-way RM-ANOVA). (F) Decreased mounting success in Katnal2-KO male mice (2–3 months), as shown by the proportion of mice that succeeded in mounting during a courtship-test session (5 min). …”

Table1_The electrocardiographic, hemodynamic, echocardiographic, and biochemical evaluation of treatment with edaravone on acute cardiac toxicity of aluminum phosphide.XLSX by Nader Rahimi Kakavandi (13908558)

“…The rats were divided into six groups, including almond oil (control), normal saline, AlP (LD₅₀), and AlP + EDA (20, 30, and 45 mg/kg). …”