CPF alone prevented ability of adipogenic cocktail (DMI) towards differentiation of C₃H₁₀T½ cells to adipocytic lineage. by Harkirat Singh Sandhu (3836335)

“…Increasing concentrations of CPF (0.01, 0.1, 1, 10, 25, 50 and 100 μM) caused a gradual decrease in lipid vesicle accumulation of DMI-treated cells (e-k). …”

Double immunohistostaining of alpha-synuclein and TH. by Nian Xiong (218611)

“…The last graph of the three rows was obtained by the overlapping the first three graphs (Scale bars = 50 µm). Compared with the contralateral side of the ST models (A-D), a dose-dependent increase in alpha-synuclein expression in the lesioned brain and a decrease in the number of TH-positive neurons are shown in E–H (3-µg group) and I–L (12-µg group). …”

Efflux of ethidium bromide. by Helen E. McNeil (8190873)

“…Data presented is the time taken for the fluorescence to decrease by 25% +/- SE. (Data for 10% and 50% drop can be seen in <a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1008101#ppat.1008101.s011" target="_blank">S1 Table</a>). …”

Effect of H3 haplotype on serum HDL-cholesterol levels in women. by Heidi J. Silver (324097)

“…In obese females, calorically restricted (−15% kcal) HF diet increased HDL-C from 50.11±11.60 mg/dl to 52.29±10.38 mg/dl in H3 haplotype carriers and decreased HDL-C from 47.99±12.90 mg/dl to 45.49±8.95 mg/dl in H3 non-carriers.…”

Tumor microenvironment facilitates the emergence of high levels of drug resistance. by Feng Fu (218124)

“…In the absence of drugs, both proliferation and turnover rates of cancer cells decrease with <i>x</i> [<a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1004142#pcbi.1004142.ref022" target="_blank">22</a>]: birth rate <i>β</i>(<i>x</i>) = <i>b</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>) and death rate <i>α</i>(<i>x</i>) = <i>d</i>₀exp(−<i>x</i>/<i>τ</i>_<i>g</i>), where the parameter <i>τ</i>_<i>g</i> is the characteristic length scale of spatial decay in proliferation and turnover rates. …”

MMR components affect the silencing at both mating-type and telomere loci. by Qian Liu (135614)

“…<p><b>(A)</b> MMR deletion strains (WT(<i>his3Δ</i>), <i>pms1Δ</i>, <i>mlh1Δ</i>, and <i>msh2Δ</i>) showed decreased mating-type cassette silencing. …”

Modeling of intercellular coupling mechanisms in a population of simulated SCN cells. by Caroline H. Ko (240081)

“…(B) Histograms of average inter-peak intervals in a simulated population of coupled cells with 100%, 20%, and 10% of total WT BMAL. These results show that as the amount of BMAL is decreased, the average period decreases and the variance in the period length increases. …”

DataSheet1_Design and evaluation of a ball spline wasp-inspired needle.xlsx by Jette Bloemberg (11665612)

“…Furthermore, evaluation in 15-wt%, 10-wt%, and 5-wt% gelatin tissue phantoms showed that decreasing the gelatin concentration decreased the mean slip ratios from 0.35 to 0.19 and 0.18, respectively. …”

<i>C. elegans</i> adapts its roaming behavior to food concentration, both by changing the dwelling/roaming percentage and the speed during the roaming phase. by Juliette Ben Arous (369742)

“…<p>(A–D) Speed histograms of WT <i>C. elegans</i> on different concentration of bacteria (A: 5 10⁴ B: 1.5 10⁵ C: 3 10⁵ D: 5 10⁵ bacteria per cm², at least 15 worms have been recorded per condition, results are presented as mean ± s.e.m.) …”

Effects of synaptic transmission on network bursts. by Davide Lonardoni (4282318)

IPSE exhibits dose-dependent heptotoxicity that is neutralized by specific monoclonal antibody. by Maha-Hamadien Abdulla (67713)

Data Sheet 1_Genetic knockdown of DYRK1A attenuates cognitive impairment, Aβ pathology, tauopathy and neuroinflammatory responses in mouse models of AD.docx by Hyun-ju Lee (7550741)

“…</p>Methods<p>To determine whether overexpressing or knocking down DYRK1A expression directly in the brain affects cognitive function, neuroinflammation and AD pathology, adeno-associated viruses (AAVs) were injected into the hippocampus of wild-type (WT), 5xFAD, and PS19 mice. Then, cognitive function was assessed via Y-maze and novel object recognition (NOR) tests, and neuroinflammatory responses and AD pathologies were analyzed by real-time PCR, Western blotting, immunofluorescence staining, AD-associated protein activity assays and ELISA.…”

Lifespan measurements of long-lived mitochondrial mutants subjected to RNAi of individual retrograde-response genes. by David Cristina (265223)

“…Right Panel - WT subjected to control (vector-only) RNAi: N = 77, m = 15.1 days; <i>clk-1(−)</i> mutants subjected to control RNAi: N = 137, m = 17.3 days; <i>clk-1(−)</i> mutants subjected to <i>fstr-1/2</i> RNAi: N = 63, m = 14.5 days. …”

Image_1_Therapy With Different Dose Regimens of Rituximab in Patients With Active Moderate-To-Severe Graves’ Orbitopathy.tif by Irene Campi (10531166)

Supplementary Material for: The impact of left ventricular structure and function on mortality in patients with aortic valve infective endocarditis treated with aortic valve replac... by figshare admin karger (2628495)

“…The mean baseline LVEDd was 5.8±0.9 cm in males and 5.0±0.9 cm in females (p<0.001), decreasing to 5.2±0.9 cm in males and 4.7±0.6 cm in females after surgery (p=0.006). …”

Astrocytic volume changes in the cortex of GFAP/EGFP and GFAP/EGFP/α-Syn^−/− mice during hyperosmotic stress. by Miroslava Anderova (155561)

High-Throughput Screening of Australian Marine Organism Extracts for Bioactive Molecules Affecting the Cellular Storage of Neutral Lipids by James Rae (210551)

“…The activity of heterofibrin A1 was dose dependent with 20 µM inhibiting LD formation and triglyceride accumulation by ∼50% in the presence of 50 µM oleic acid. …”

Hit expansion around chloroxine. by Sam Barker (4832121)

“…This modification causes a significant decrease in this compound’s activity as a co-treatment with ceftazidime, with a <i>p</i>IC50 ≈ 3.4. 5,7-dichloro-2-methyl-8-quinolinol differs from chloroxine by addition of a methyl group in the 2-position (B). …”

Effect of BC-819 on cell growth in different lung cancer cell lines. by Günther Hasenpusch (350166)

“…The influence of BC-819 on bioluminescent A549-C8-luc was examined as well and revealed decreased luciferase and therefore reduced cell growth (more than 50%) as early as after 24 hours (C). …”

Dissociation, and not specific actions of Trypsin-EDTA, acts to suppress neurectoderm formation. by James N. Hughes (319868)

“…Error bars represent sem. (a) denotes a decrease compared to MEDII⁻/Dissociation⁻ where p<0.01. …”