PKC signaling and calcineurin independently regulate tolerance to ergosterol biosynthesis inhibitors via a common target in <i>C. albicans</i>. by Shantelle L. LaFayette (243114)

“…(<b>B</b>) Simultaneous inhibition of calcineurin and Pkc1 signaling does not synergistically decrease FL tolerance of a WT strain (SN95). A fractional inhibitory concentration (FIC) assay was carried out in YPD medium containing a fixed concentration of 0.5 µg/mL FL and gradients of the calcineurin inhibitor cyclosporin A (CsA) and the PKC inhibitor staurosporine (STS). …”

Data_Sheet_1_Improving the Lifetime of CsPbBr3 Perovskite in Water Using Self-Healing and Transparent Elastic Polymer Matrix.docx by Livy Laysandra (9462983)

“…The tensile strength and stretching ability of 5 wt% perovskite content in the random copolymer were observed to be 3.8 MPa and 553.5% respectively. …”

Table1_Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic pat... by Boris Jakopovic (9265517)

“…</p>Methods<p>In this study, we performed both qualitative and quantitative proteomic analyses using tandem mass tags (TMT) on CT26 wild type (CT26. WT) colon cancer tissues from Balb/c mice, which were treated with a special blend of medicinal mushroom extracts, either alone or in combination with the chemotherapy drug 5-fluorouracil.…”

DataSheet1_Proteomic study of medicinal mushroom extracts reveals antitumor mechanisms in an advanced colon cancer animal model via ribosomal biogenesis, translation, and metabolic... by Boris Jakopovic (9265517)

“…</p>Methods<p>In this study, we performed both qualitative and quantitative proteomic analyses using tandem mass tags (TMT) on CT26 wild type (CT26. WT) colon cancer tissues from Balb/c mice, which were treated with a special blend of medicinal mushroom extracts, either alone or in combination with the chemotherapy drug 5-fluorouracil.…”

Supplementary Material for: Improvement of in situ Follicular Activation and Early Development in Cryopreserved Human Ovarian Cortical Tissue by Co-Culturing with Mesenchymal Stem... by Hosseini M. (8610126)

Loss of <i>Fgf3</i> causes variable anterior-posterior axis truncation and caudal malformation. by Matthew J. Anderson (265883)

“…<i>Fgf3</i> mRNA is detected in the primitive streak (<b>ps</b>, E7.5, E8.5) as well as in the presomitic mesoderm (E8.5–12.5) and tail bud (E9.5–12.5). …”

<i>Sim1</i> loss-of-function <i>in vitro</i> and <i>in vivo</i>. by Nadja Osterberg (352748)

“…B-M: In situ hybridization for <i>Pet1</i> (B-E), <i>RGS4</i> (F-I) and <i>Brn3.2</i> (J-M) in wild type (<i>wt</i>) and <i>Sim1-/-</i> mutants at P0. <i>Pet1</i> expression was observed in the area of rostral 5-HT neurons (B) including the area of dorsal raphe in <i>wt</i> (C: magnification of the inset in B), but was considerably decreased in <i>Sim1-/-</i> (D). …”

Knockout animals are less persistent and less consistent in their drinking behavior. by Admir Resulaj (12368645)

“…(D) This plot controls for the possibility that KO animals have a higher lick rate than WT and thus fatigue more quickly. KO and WT animals perform, on average, the same number of licks per trial (mean ± std: 23.2 ± 9.9 CD/trials for KO versus 29.4 ± 5.8 CDs/trial for WT; p > 0.17, two-sided t-test). …”

Inhibitory effect of TF3 on Hla production by <i>Staphylococcus aureus</i> USA300. by Anna Goc (316065)

“…(B) Densitometry of western blot bands. (C) Dose-dependent decrease in <i>hla</i> and <i>agr</i>A genes expression by <i>S</i>. …”

Temporal and Spatial Profiling of Root Growth Revealed Novel Response of Maize Roots under Various Nitrogen Supplies in the Field by Yunfeng Peng (163529)

“…Early N excess, deficiency, or delayed N topdressing reduced plant N content, resulting in a significant decrease in dry matter accumulation and grain yield. …”

Video_3_Electrophysiological Characterization of Human Atria: The Understated Role of Temperature.MP4 by Rupamanjari Majumder (128411)

“…Our studies show that different parts of the atria react differently to the same changes in temperature. In tissue simulations a drop in temperature correlated positively with a decrease in CV, but the decrease was region-dependent, as expected. …”

Mutational scanning of autologous virus. by Collin Joyce (16469212)

“…The top panel shows fold increase/decrease while the bottom shows IC₅₀ (μg/ml). …”

Effect of replacing beef fat with safflower oil on physicochemical, nutritional and oxidative stability characteristics of wieners by Emel KAYNAKCI (10463779)

“…Incorporation of SO increased CIE L* and b* values, whereas it caused a decrease in CIE a* values of wieners (P < 0.05). …”

Label-free real-time multi-parametric monitoring enables high content analysis. by Heinz-Georg Jahnke (122745)

“…The effect on the APD was determined for one hour after doxorubicin application and revealed a concentration dependent response with an EC₅₀ value of 17 µM (n  = 3 hCMC), (B) The impedance analysis revealed a concentration- and time-dependent decrease where IC₅₀ values could be determined for each time point (n  = 5 hCMC). …”

Detection of the HIF-1alpha redox state by PEG-maleimide. by Yukino Kobayashi (2461102)

“…(B) Hep3B cells were cultured under hypoxic conditions for 6 h and harvested with 50 mM Hepes, pH 7.5, containing 0.5% Nonidet P-40. …”

Alteration of DS craniofacial features in Dp(16)1Yey is observed during late development. by José Tomás Ahumada Saavedra (22290934)

“…(C) Magnification of lateral view of skeletal staining, WT vs Dp(16)1Yey at E18.5 (2 individuals). Red arrows showing less mineralization in nasal bones, neurocranium, and form defect in atlas vertebrae. …”

<b>Bleomycin-induced lung fibrosis and dysfunction is exacerbated by G6PD deficiency</b> by Christina Signoretti (17980047)

“…In addition, mass-spectrometry-based proteomics and spatial proteomics confirmed increased expression of pro-fibrotic proteins, including collagen1a1 and baculoviral IAP Repeat Containing 5, in the lungs of G6PD^S188F+ BLM rats compared to WT + BLM rats. …”

Positive feedback in <i>CLN2</i> activation and the coherence of entry into Start. by Debashis Barik (3389255)

“…</b> As the rate constant for phosphorylation of Whi5 by Cln1,2 (i.e., the strength of the Cln1,2-mediated positive feedback loop) is progressively decreased (in panels C1-C5), the coherence of gene activation upon entry into Start decreases. …”

Data Sheet 1_Thermodynamic integration in combined fuel and power plants producing low carbon hydrogen and power with CCUS.docx by Daniel Mullen (5681870)

“…The CFP configuration reduces the overall quantity of flue gas to be processed by 36%–37% and increases the average CO₂ concentration of the flue gas to be treated from 9.9% to 14.4% (wet). This decreases the absorber packing volume requirements by 41%–56% and decreases the specific reboiler duty by 5.5% from 3.46–3.67 GJ/tCO₂ to 3.27–3.46 GJ/tCO₂, further increasing the 2nd law thermal efficiency gains to 3.8%–4.4% points over the un-integrated case. …”

Kinases are recruited to the signaling complex by alternative N-t localization domains. by Paloma M. Sato (672126)

“…In most cases, mutations that disrupt specific recruitment interactions decrease pathway activation between 40%–50%. MUT Ste20[N]-Ste50[C] might still localize to the signaling complex, as Ste50's RA domain binds Cdc42 independently of Ste20's PBD domain <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002012#pbio.1002012-Truckses1" target="_blank">[53]</a>. …”