Enzymatic Mechanism of Human Apurinic/Apyrimidinic Endonuclease against a THF AP Site Model Substrate by Sophia T. Mundle (303078)

“…Therefore, it is essential to accurately and directly characterize the enzymatic mechanism of AP endo. Here we describe specifically designed double-stranded DNA oligomers containing tetrahydrofuran (THF) with a 5′-phosphorothioate linkage as the abasic site substrate. …”

Enzymatic Mechanism of Human Apurinic/Apyrimidinic Endonuclease against a THF AP Site Model Substrate by Sophia T. Mundle (303078)

“…Therefore, it is essential to accurately and directly characterize the enzymatic mechanism of AP endo. Here we describe specifically designed double-stranded DNA oligomers containing tetrahydrofuran (THF) with a 5′-phosphorothioate linkage as the abasic site substrate. …”

Table1_Integration of Transcriptomics and Metabolomics Reveals the Antitumor Mechanism Underlying Tadalafil in Colorectal Cancer.docx by Pan Zhao (359084)

“…Amino acid metabolism-related genes, GPT, GGT5, and TAT, were significantly decreased after tadalafil treatment. …”

DataSheet1_Simultaneous silencing of juvenile hormone metabolism genes through RNAi interrupts metamorphosis in the cotton boll weevil.PDF by Daniel D. N. Vasquez (14721448)

“…PEI nanoparticles increased targeted gene silencing compared with naked dsRNAs (up to 80%), whereas CS-TPP-dsRNA nanoparticles decreased gene silencing (0%–20%) or led to the same level of gene silencing as the naked dsRNAs (up to 50%). …”

Multiple modality biomarker prediction of cognitive impairment in prospectively followed de novo Parkinson disease by Chelsea Caspell-Garcia (4030664)

“…Biomarkers, some longitudinal, predicting cognitive impairment in multivariable models were: (1) dopamine deficiency (decreased caudate and putamen DAT availability); (2) diffuse, cortical decreased brain volume or thickness (frontal, temporal, parietal, and occipital lobe regions); (3) co-morbid Alzheimer’s disease Aβ amyloid pathology (lower CSF Aβ 1–42); and (4) genes (<i>COMT</i> val/val and <i>BDNF</i> val/val genotypes).…”

Schematic overview of the model. by Lin L. Liu (822000)

Effects of clinical and environmental factors on bronchoalveolar antibody responses to <i>Pneumocystis jirovecii</i>: A prospective cohort study of HIV+ patients by Robert J. Blount (292240)

“…Prior PCP was associated with increased BALF IgA responses to Msg and current PCP was associated with decreased IgA responses. For instance, among patients without current PCP, those with prior PCP had a median 73.2 U (IQR 19.2–169) IgA response to MsgC1 compared to a 5.00 U (3.52–12.6) response among those without prior PCP. …”

DataSheet1_Identification of Potential Diagnoses Based on Immune Infiltration and Autophagy Characteristics in Major Depressive Disorder.docx by Ye Sun (95796)

“…Finally, 10 key ARMGs were identified through PPI analysis: RAB1A, GNAI3, VAMP7, RAB33B, MYC, LAMP2, RAB11A, HIF1A, KIF5B, and PTEN. In the CUMS model, flow cytometric analysis confirmed the above findings. qRT–PCR revealed significant decreases in the mRNA levels of Gnai3, Rab33b, Lamp2, and Kif5b in the CUMS groups.…”

DataSheet1_Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover.pdf by Javier Martínez-Reina (849042)

“…However, bone loss observed 24 months after Dmab withdrawal is less pronounced in patients with high BW (3.5% for 80kg and 8.5% for 60 kg). Finally, we studied how to safely discontinue Dmab treatment by exploring several transitional and combined drug treatment strategies. …”

DataSheet1_Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover.pdf by Javier Martínez-Reina (849042)

“…However, bone loss observed 24 months after Dmab withdrawal is less pronounced in patients with high BW (3.5% for 80kg and 8.5% for 60 kg). Finally, we studied how to safely discontinue Dmab treatment by exploring several transitional and combined drug treatment strategies. …”

DataSheet1_Assessment of Strategies for Safe Drug Discontinuation and Transition of Denosumab Treatment in PMO—Insights From a Mechanistic PK/PD Model of Bone Turnover.pdf by Javier Martínez-Reina (849042)

“…However, bone loss observed 24 months after Dmab withdrawal is less pronounced in patients with high BW (3.5% for 80kg and 8.5% for 60 kg). Finally, we studied how to safely discontinue Dmab treatment by exploring several transitional and combined drug treatment strategies. …”

Simulated 2D tissue realizations with randomly placed non-overlapping RBCs under periodic boundary conditions. by Ratan K. Saha (293995)

Supplementary Material for: Heterochronic development of the perception of different types of visual illusions by Navarrete V. (20470208)

“…Inconsistencies persist in the empirical findings for understanding how the perception of these illusions evolves over the course of development. Methods: We assessed 513 participants between 6.5 and 18.9 years of age, with 103 pairs of illusory and control images spanning five illusion types (Ebbinghaus, Müller-Lyer, Contrast, Moving Snake, and Subjective Contour). …”

Data_Sheet_1_Metabolomic profiling of CSF and blood serum elucidates general and sex-specific patterns for mild cognitive impairment and Alzheimer’s disease patients.docx by Georgy Berezhnoy (11580361)

“…When investigating the effect of sex, we found for AD males the sign of decreased 2-hydroxybutyrate and acetoacetate in CSF while for AD females increased serum creatinine was identified.…”

Proportional Venn analysis of significantly changed gene regions as determined by multiarray analyses. by Joseph Andrews (255049)

Datasheet1_Differences in cardiovascular risk factors associated with sex and gender identity, but not gender expression, in young, healthy cisgender adults.pdf by Jennifer S. Williams (12291680)

“…Participants completed a questionnaire capturing sex category (50 male/80 female), gender identity category (49 men/79 women/2 non-binary), and aspects of gender expression assessed by the Bem Sex Role Inventory-30 (39 androgynous/33 feminine/29 masculine/29 undifferentiated). …”

SufT participates in Fe-S cluster biogenesis and repair. by Ashutosh Tripathi (2827796)

“…<p>(A) Western blot quantification of reduced SufT protein level (green bars) and decreased aconitase (Acn) activity (brown bars) was shown in SufT-KD strain, with increasing concentration (ng/mL) of ATc (0, 50, 100, 200 and 400). …”

Datasheet1_Differences in cardiovascular risk factors associated with sex and gender identity, but not gender expression, in young, healthy cisgender adults.pdf by Jennifer S. Williams (12291680)

“…Participants completed a questionnaire capturing sex category (50 male/80 female), gender identity category (49 men/79 women/2 non-binary), and aspects of gender expression assessed by the Bem Sex Role Inventory-30 (39 androgynous/33 feminine/29 masculine/29 undifferentiated). …”

Cortical bone in NF1 tibial dysplasia is characterized by heterogeneous mineralization, diminished collagen thickness and increased micro-porosity. by Jirko Kühnisch (108599)

“…<p>(A) MicroCT analysis of human cortical bone samples (tibia). …”

Immunocytochemistry, RT-PCR and Q-PCR analyses of neonatal ‘RSCs’ during <i>in vitro</i> cultivation. by Magdalena Czekaj (314406)

“…Gene expression levels are related to the mean expression levels of housekeeping genes. Scale bar: 50 µm. …”