Discovery of the Triazolo[1,5‑<i>a</i>]Pyrimidine-Based Derivative WS-898 as a Highly Efficacious and Orally Bioavailable ABCB1 Inhibitor Capable of Overcoming Multidrug Resistance... by Shuai Wang (109515)

Subjects:

Gene ontology biological processes overrepresented among genes exhibiting decreased expression in human psoriasis. by William R. Swindell (175427)

“…<p>A total of 3540 transcripts were identified as significantly decreased in psoriatic plaques obtained from human patients relative to normal skin obtained from control subjects (FDR-adjusted P<0.05 and log₂-transformed fold-change less than -0.50). …”

FGF8b decreased GnRH mRNA in GT1-7 cells. by Natasha N. Mott (341221)

FG-2216 decreased plasma markers of cardiac injury in Nx-Ob-ZSF1 rats. by Pierre E. Signore (11218497)

Mean fecal egg count per individual before and after administration of a single oral dose albendazole. by Martin Walker (170282)

<i>In vivo</i> sibutramine administration decreases the tyramine-induced tension of epididymal cauda duct. by Cibele S. Borges (420750)

Ionic currents of aglycoform decreased more readily during repetitive depolarization pulses than glycoform. by M. K. Hall (352643)

B-RAF inhibitor PLX4720 decreased hERG currents in rhabdomyosarcoma RD cells. by Tatsiana Pakladok (311653)

Chk1 protein stability is decreased after siRNA knockdown of CK1δ. by Yoshimi Endo Greer (3710131)

Small RNR subunit interaction with Ydj1 is decreased in Ssa3 and Ssa4 cells. by Laura E. Knighton (5991239)

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Here, we synthesized a newseries of <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives. …”

Synthesis and Antiproliferative Activity of a New Series of Mono- and Bis(dimethylpyrazolyl)‑<i>s</i>‑triazine Derivatives Targeting EGFR/PI3K/AKT/mTOR Signaling Cascades by Ihab Shawish (13015516)

“…Here, we synthesized a newseries of <i>mono</i>- and <i>bis</i>(dimethylpyrazolyl)-<i>s</i>-triazine derivatives. …”

Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling. by David Mellis (2833469)

Gametocyte numbers can increase (A) or decrease (B, C) even when transmission investment is constant over the time period observed. by Megan A. Greischar (2150737)

“…<p>For clarity, we assume that replication and gametocyte development both require one day and 50% of new gametocytes persist for an additional day (“Old gametocytes”). …”

Decreased proliferation and increased apoptosis in <i>Mab21l2</i> mutant embryos. by Yohei Saito (180130)

“…BrdU staining shows decreased cell proliferation in the trabecular myocardium and compact myocardium (asterisk) of left (F) and right ventricle (E) in <i>Mab21l2</i> mutant (D–F) compared to WT embryos (A–C). …”

Sustained expression of radmis results in decreased cell proliferation and increased cell-cycle exit of NSPCs. by Takahito Yumoto (481671)

Basal ubiquitination of GlyT2 in neurons decreases when the pool of free monomeric ubiquitin is reduced. by Jaime de Juan-Sanz (386083)

Loss of fenestrations and decreased VEGF production in <i>Cyp1b1-/-</i> LSEC. by Juliana Falero-Perez (5905103)

“…Clusters of fenestrations were found aligned in the peripheries of <i>Cyp1b1</i>+/+ LSEC with the expected size of 50–200 nm in diameter [<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0206756#pone.0206756.ref019" target="_blank">19</a>, <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0206756#pone.0206756.ref020" target="_blank">20</a>] (left, arrowheads). …”

ApoE3 decreases Rho activity and F-actin stress fibers in human VSMCs. by Bernadette Y. Hsu (753458)

TBEV-induced translational arrest results in the decreased protein levels of GAPDH, HPRT1, and viperin. by Martin Selinger (3195987)