SB225002 induces apoptosis and mitosis in distinct p53-dependent manners. by Meirong Du (276744)

“…B: Silencing p53 [p53 siRNA (100 nM, 36 h, or scramble siRNA (control)] decreased SB225002 (750 nM, 24 h)-induced apoptosis but not mitosis in OV2008 and C13* cells. …”

HVN Antidiabetic Metadata Record - The effect of antidiabetic drugs on the metabolism of peripheral blood immune cells by Olivier Gasser (8511666)

“…Blood samples of up to 100 participants with type 2 diabetes will be collected before and around 12 weeks after starting a new antidiabetic treatment. …”

Effects of E2F1 on the abilities of in vitro cell motility and migration. by Xin Ma (37268)

“…In 100 times microscope, areas of scraping cells were counted. …”

PARP1 level is reduced in myotubes. by Gábor Oláh (5664550)

“…<b>(C)</b> The effect of differentiation on protein expression of PARP-1 and the differentiation markers, PCNA, Pax7, and myogenin were monitored on Days 0–7 using whole cell extracts. Actin was used as a loading control. The relative quantity of proteins was calculated by densitometry and normalized to actin based on the analysis of three independent Western blots. * indicates <i>p<</i>0.05 relative to myoblasts at Day 0 (100%). …”

Optimum values for RotaMol parameters. by Sebastian Eves-van den Akker (515790)

“…<p>(<b>A</b>) RotaMol analysis of mRFP at θ = 30° varying Pixelskip in a stepwise manner from 3 to 100. …”

Contractility mediated by KCl, phenylephrine and angiotensin II. by Els Moltzer (210717)

“…<p>(A) In ascending aortas, KCl-induced contractility decreased in a gene dose-dependently in Fibulin-4^+/R and Fibulin-4^R/R mice (p for trend <0.001). …”

<i>d-myc</i> knockdown can rescue the Malpighian tubule defects of <i>BicC</i> mutants. by Chiara Gamberi (499883)

“…<i>d-myc</i> RNAi rescued greatly the morphology of the Malpighian tubule. Boxed regions in (A) and (D) are shown enlarged respectively in (B, C) and (E). …”

The difference between healthy control (HC, white bar) and type 2 diabetic patients who have no clinical neuropathy (no clinical neuropathy, black bar) in sensory nerve excitabilit... by Jia-Ying Sung (3737626)

“…<p><b>(A)</b> No clinical neuropathy group shows greater threshold stimulus for 50% SNAP, <b>(B)</b> shorter strength-duration time constant (SDTC), <b>(C)</b> increased superexcitability, <b>(D)</b> decreased subexcitability, <b>(E)</b> greater peak of TEd, and <b>(F)</b> the TEh in a 90–100 ms time window. …”

Results of preliminary experiments to determine the stimulation intensity and time. by Yuichiro Honda (10797856)

“…<p>(A) Preliminary experiment to determine the stimulus intensity. …”

Effect of MRS on TRVPV1-mediated Ca²⁺ signaling. by Mustafa Nazıroğlu (4167676)

“…<b>H)</b> Neither MCF7 cell extracts nor CAPS (50 μM) evoked an elevation in Ca²⁺]_i in control (un-transfected) NIH-3T3 cells; a Ca²⁺ signal was induced by serum re-administration <b>I)</b> Application of a MCF7 cell extract increased [Ca²⁺]_i in NIH-3T3^TRPV1 cells; the Ca²⁺ signal was further increased by CAPS (50 μM). …”

PPM1A facilitates both nuclear distribution and transcription potency of YAP/TAZ. by Ruyuan Zhou (10197187)

“…<b>(B–D)</b> Transcription potency of YAP (5 ng), which was suppressed by coexpression of MST1 (50 ng) (B), LATS1 (500 ng) (C), or MAP4K1 (50 ng) (D), was markedly recovered by cotransfection of wild-type PPM1A but not the enzyme-dead PPM1A (D239N). …”

Pharmacologic suppression of GABA_A receptor function differentially affects sleep in control and GEFS+ flies. by Emily Petruccelli (794164)

Start-Up of an Anaerobic Dynamic Membrane Digester for Waste Activated Sludge Digestion: Temporal Variations in Microbial Communities by Hongguang Yu (545882)

NaSal failed to increase excitability of 5-HTergic neurons in the absence of the GABAergic inhibition in the DRN of the ChR2 transgenic mouse. by Yan Jin (143500)

“…(B) Sample recordings from a 5-HTergic neuron showing that NaSal decreased voltage responses to a series of hyperpolarizing currents (-10 to -60 pA, -10 pA/step, duration: 500 ms). …”

TAD boundary stability for different noise amplitudes for all chromosomes. by Lucas Hedström (21688891)

“…<p>The dash-dotted lines show the modified Jaccard index in <a href="https://journals.plos.org/complexsystems//article/info:doi/10.1371/journal.pcsy.0000053#pcsy.0000053.e047" target="_blank">Eq 9</a> (averaged over 100 samples per chromosome). …”

ACSVL3 knockdown in lung cancer cell lines. by Zhengtong Pei (418650)

“…Control lines stably harbor a plasmid containing a scrambled sequence that does not target any human or rodent mRNA. …”

Table_1_Sustainable citric acid production from CO2 in an engineered cyanobacterium.xlsx by Lifang Zhang (130786)

“…Decreased citric acid cycle flux, through the use of a theophylline-responsive riboswitch, was combined with improved flux through citrate synthase and enhanced citric acid excretion, resulting in a significant improvement to citric acid production. …”

Image_2_Sustainable citric acid production from CO2 in an engineered cyanobacterium.TIF by Lifang Zhang (130786)

“…Decreased citric acid cycle flux, through the use of a theophylline-responsive riboswitch, was combined with improved flux through citrate synthase and enhanced citric acid excretion, resulting in a significant improvement to citric acid production. …”

AT101-induced autophagy in MPNST cells is not cytoprotective. by Niroop Kaza (563598)

“…AT101 causes an increase in autophagic flux in MPNST cells as evidenced by increased LC3 II levels in cells treated with both AT101 (10 µM for 24 hours) and BafA1 (100 nM, added 4 hours before collection of lysates) compared to either drug alone (C). …”

Expression of MMPs in heparanase transfected MDA-231 human breast carcinoma cells. by Eyal Zcharia (323457)

“…Heparanase (A) and MMPs (B) mRNA expression levels were determined by real-time PCR, as described under “<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0005181#s2" target="_blank">Materials and Methods</a>”. …”