DataSheet1_In situ spatiotemporal mapping of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor in pineapple (Ananas comosus) fruit tissue by MALDI mass spectrometry imagin... by Angelica Faith L. Suarez (8756553)

“…The MALDI mass spectrometry imaging (MSI) enabled the in situ spatiotemporal mapping of the HMGCR inhibitor, N1, N10-diferuloylspermidine, in the pineapple fruit tissue, with localization concentrated mainly in the tissue near the peel/shell and a gradual decrease towards the flesh and ovary. …”

DataSheet1_In situ spatiotemporal mapping of 3-hydroxy-3-methylglutaryl-CoA reductase (HMGCR) inhibitor in pineapple (Ananas comosus) fruit tissue by MALDI mass spectrometry imagin... by Angelica Faith L. Suarez (8756553)

“…The MALDI mass spectrometry imaging (MSI) enabled the in situ spatiotemporal mapping of the HMGCR inhibitor, N1, N10-diferuloylspermidine, in the pineapple fruit tissue, with localization concentrated mainly in the tissue near the peel/shell and a gradual decrease towards the flesh and ovary. …”

Image_4_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.png by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

Image_2_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

Image_1_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

Image_3_Periplasmic Expression of 4/7 α-Conotoxin TxIA Analogs in E. coli Favors Ribbon Isomer Formation – Suggestion of a Binding Mode at the α7 nAChR.JPEG by Yamina El Hamdaoui (6759080)

“…Two-electrode voltage clamp analysis on oocyte-expressed nAChR subtypes demonstrated the functionality of these peptides but also revealed a 30 to 100-fold potency decrease of expressed TxIA compared to chemically synthesized TxIA. …”

8-Propyl-6H-[1,3]dioxolo[4,5-g]chromen-6-one: A new coumarin with monoamine oxidase B inhibitory activity and possible anti-parkinsonian effects by María del Pilar Olaya (12848792)

“…FCS303 inhibited monoamine oxidase B (MAO-B) with an IC50 of 5.46 ± 0.36 µM; however, there was no effect on monoamine oxidase A (MAO-A). The oral administration of FCS303 led to a significant reversal of hypokinesia in the reserpine model (at 24 h, doses of 100 and 200 mg/kg) and in the levodopa/carbidopa potentiation assay (at 2 and 24 h, dose of 200 mg/kg). …”

Data Sheet 1_Global burden of ischemic heart disease attributable to ambient and household PM2.5 exposure: a comprehensive analysis (1990–2021) from socioeconomics perspective.pdf... by Chenran Zhang (4443106)

“…</p>Results<p>From 1990 to 2021, age-standardized rates (ASMR, ASDR) of IHD attributable to ambient PM_2.5 declined to 20.85 per 100,000 (AAPC = −0.7), with attributable to household PM_2.5 decreased to 9.02 per 100,000 (AAPC = −2.49). …”

Supplementary file 1_Global, regional, and national burden of iodine deficiency for women of reproductive age, 1990–2021: a systematic analysis based on the Global Burden of Diseas... by Taotao Wang (115296)

“…</p>Methods<p>Utilizing data from the Global Burden of Disease Study 2021, this study reports age-standardized rates per 100,000 population and average annual percentage changes (AAPCs) in incidence, prevalence, and years lived with disability (YLD) of iodine deficiency among WRA, facilitating a comparative analysis of the burden across regions and nations. …”

Immunofluorescence images from age-matched 3-month old Tg (A) and control (B) rats and from age-matched 7-month old Tg (C) and control (D) rats. by Margaret R. Lentz (364986)

“…Each row shows GFAP staining in yellow, NFH staining in Blue and a composite image of both (magnification 100X, scale bar = 40 µm). …”

Data_Sheet_1_Potential lipid-lowering effects of Ulmus macrocarpa Hance extract in adults with untreated high low-density lipoprotein cholesterol concentrations: A randomized doubl... by Ye Li Lee (14036589)

“…</p>Results<p>UME over 12 weeks led to a greater decrease in LDL-C, TC, and ApoB concentrations than did the placebo as follows: by 18.1 mg/dl (P < 0.001); 23.3 mg/dl (P < 0.001); 9.3 mg/dl (P = 0.018), respectively. …”

Data_Sheet_1_Electroacupuncture for the Prevention of Postoperative Cognitive Dysfunction Among Older Adults Undergoing Hip and Knee Arthroplasty: A Systematic Review and Meta-Anal... by Liang Ou (73724)

“…<p>Background: Postoperative cognitive dysfunction (POCD) is a common surgical complication in elderly patients undergoing hip and knee replacement. …”

Data_Sheet_1_The Efficacy and Safety of Pirfenidone Combined With Immunosuppressant Therapy in Connective Tissue Disease-Associated Interstitial Lung Disease: A 24-Week Prospective... by Jiaqi Wang (369548)

“…However, in IIM patients with a non-UIP tendency, PFD displayed better therapeutic effects than the control (10.50 vs. 1.00%). …”

Fluoro-Ruby-labeled motoneurons at 13 weeks after immediate nerve repair (A), 1 months delayed repair (B), 3 months delayed repair (C) and 6 months delayed repair (D). by Samuel Jonsson (284555)

Immunostaining of nucleostemin (NS) (A–C), semi-quantitation (D) and qRT-PCR analysis of gene expression (E, F) in aging TSCs subjected to mechanical loading <i>in vitro</i>. by Jianying Zhang (256508)

“…<p>Patellar TSCs isolated from aging mice (9 months old) were subjected to no stretching (Control), 4% stretching or 8% stretching followed by the analyses. Immunostaining (<b>A–C</b>) and semi-quantitation (<b>D</b>) showed that compared to the control without stretching, 4% stretching increased the number of NS-expressing TSCs, whereas 8% stretching further decreased it. qRT-PCR analysis of the expression of three stem cell and tenocyte-related genes, Nanog, collagen I and tenomodulin (<b>E</b>) and three non-tenocyte related genes, LPL, Sox-9 and Runx-2 (<b>F</b>) showed that 4% stretching effectively up-regulated Nanog, collagen I and tenomodulin, but 8% was less effective (<b>E</b>). …”

FIGURE 2 from D-2-HG Inhibits <i>IDH1^mut</i> Glioma Growth via FTO Inhibition and Resultant m6A Hypermethylation by Sean T. Pianka (18237413)

“…IDH1^mut inhibitors (C35 = 2 µmol/L; AG881 = 1 µmol/L) enhance growth of <i>IDH1^mut</i><b></b>patient-derived gliomaspheres HK252 (<b>A</b>) and HK211 (<b>B</b>). <b>C,</b> Effect of <i>IDH1^mut</i> forced expression in <i>IDH1^wt</i> gliomaspheres (HK385, HK217, and HK250) on gliomasphere growth relative to vector control [ANOVA, <i>F</i>(1,1056) = 199.0, <i>P</i> ≤ 0.0001; asterisks indicate <i>post hoc</i> Newman–Keuls comparison with vector], showing decreased overall growth in <i>IDH1^mut</i>. …”

Can Topical Insect Repellents Reduce Malaria? A Cluster-Randomised Controlled Trial of the Insect Repellent <i>N,N</i>-diethyl-<i>m</i>-toluamide (DEET) in Lao PDR by Vanessa Chen-Hussey (445411)

“…Intention to treat analysis found no effect from the use of repellent on malaria incidence (hazard ratio: 1.00, 95% CI: 0.99–1.01, p = 0.868). A higher socio-economic score was found to significantly decrease malaria risk (hazard ratio: 0.72, 95% CI: 0.58–0.90, p = 0.004). …”

DataSheet1_Effects of the peripheral CB1 receptor antagonist JD5037 in mono— and polytherapy with the AMPK activator metformin in a monocrotaline-induced rat model of pulmonary hyp... by Patryk Remiszewski (13594804)

“…Animals received metformin (100 mg/kg), JD5037 (3 mg/kg), or a combination of both once daily for 21 days. …”

Table 2_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.docx by Yue Song (162328)

“…</p>Methods<p>A cold-coagulation type dysmenorrhea model was established in rats, which were divided into the control group, model group, low-frequency electroacupuncture group (2/10 Hz), and high-frequency electroacupuncture group (20/100 Hz). …”

Table 4_Effects of low-frequency and high-frequency electroacupuncture pretreatment on the COX-2/mPGES-1/PGE2 pathway in a rat model of cold-coagulation dysmenorrhea.docx by Yue Song (162328)

“…</p>Methods<p>A cold-coagulation type dysmenorrhea model was established in rats, which were divided into the control group, model group, low-frequency electroacupuncture group (2/10 Hz), and high-frequency electroacupuncture group (20/100 Hz). …”