Image2_Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011.jpg by Tara Smith (2558311)

“…Further tissue distribution was examined using quantitative whole-body autoradiography after both single and repeat daily doses at 100 mg/kg/day. Non-compartmental analysis showed that following a single dose, PPI-1011 exhibited peak levels between 6 and 12 h but also a long half-life with mean t_1/2 of 40 h. …”

Fig 11 - by Maike Stegen (8578665)

“…Actin β at approx. 40 kDa (molecular weight 43 kDa) was used as a reference on a stripped membrane. Stimulation with 100 nM PMA led to a distinct decrease in GRK6 protein expression. …”

Penile cancer trends and economic burden in the Brazilian public health system by Fernando Korkes (5910167)

“…Conclusion: Despite the decrease in admissions, penile cancer still imposes a significant economic and social burden to the Brazilian population and the Public Health System.…”

cAMP dynamics in adult mouse ventricular Epac1-camps expressing cardiomyocytes upon treatment with cAMP elevating agents and PDE4 inhibition. by Julia U. Sprenger (3387719)

“…<b>(C)</b> Representative FRET traces from Epac1-camps cardiomyocytes stimulated with the β-AR agonist isoproterenol (ISO, 100 nM) or <b>(E)</b> with the direct AC activator forskolin (10 μM) leading to an increase of cAMP visualized as a decrease in the FRET ratio. …”

SR Ca²⁺ uptake, Ca²⁺ signaling proteins, and transcriptional factors. by Mei Hua Gao (458915)

“…<b>Lower:</b> Expression of AC6mut decreased SERCA2a affinity for Ca²⁺. The effective concentration of Ca²⁺ for 50% maximal effect (EC₅₀) was calculated from the initial ATP-dependent Ca²⁺ uptake rate at different free Ca²⁺ concentrations. …”

Characterization of human neural progenitor cell (hNPC) derived neurons during neuronal differentiation. by Xuan Yuan (225365)

“…There was decreased density of VGAT and synapse formation in the hNPC-derived neurons from <i>PIGA</i>c.1234C>T cells compared to the control cell line (<i>PIGA</i>wt) (<a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174074#pone.0174074.s003" target="_blank">S3 Fig</a>). …”

Validation of the primary screen hits with secondary luciferase-based invasion and red-green invasion assays. by Rajshekhar Y. Gaji (417441)

“…The values obtained with non-targeting siRNA controls were set at 100% invasion. A total of 81 genes (red asterisks) showed significant decrease (<i>p</i><0.05, one sample <i>t</i>-test) in parasite invasion compared to NTsiRNA controls. …”

Expression of MMP7 and TIMP1 in wounds. by Katharina Sommer (463202)

“…Septic animals show a significant decrease in MMP7 expression on day 2 and 6 compared to control mice. …”

Characterisation and influence of the content of waste foundry sand on rendering mortars by Juliana Machado Casali (4696111)

“…The results demonstrated that the waste foundry sand had an influence on the properties of the mortars in fresh state (mainly for the mortar with 100% waste foundry sand, which required the use of a larger amount of water to obtain the same consistence) and in the hardened state (decrease in strength, mass density and modulus of elasticity). …”

Ca²⁺ sparklets in DSM are affected by, but not dependent upon, signals from the SR. by Peter Sidaway (190696)

“…In the presence of the VGCC antagonist R-(+)-Bay K 8644 (1 μM) and CPA (10 μM), there was a significant decrease in the frequency (D) but not amplitude (E) of Ca²⁺ sparklets. …”

Glycosylation inhibitors block thrombin-induced sRBC adhesion to HUVECs. by Pushpankur Ghoshal (580530)

“…The level of sRBC adhesion to untreated HUVECs was set to 100%. **, p<0.0001 <b>B</b>. Glycosylation inhibitors decrease thrombin-induced sRBC adhesion to HUVECs. …”

Transcripts differentially expressed in response to overexpression of and in response to overexpression of human , grouped according to functional classes by Haiqiong Montalta-He (54730)

“…Positive values indicate that the relative expression level of a gene is increased (upregulated) following overexpression and negative values indicate a decrease (downregulated). …”

Astrocytic volume changes in the cortex of GFAP/EGFP and GFAP/EGFP/α-Syn^−/− mice during hypoosmotic stress. by Miroslava Anderova (155561)

“…The changes of astrocytic volume during washout were evaluated in each individual cell and expressed as an average percent of cell volume increase/decrease related to the maximal volume after 30 minutes of aCSF_H-50 (<b>C right</b>) or aCSF_H-100 (<b>D right</b>) exposure; these values were set as 0%. …”

Histology of islet allografts at day 10, 17, 24, and 31 after transplantation in non-diabetic mice. by Jyuhn-Huarng Juang (407970)

“…There was profound immune cell infiltration at day 10 and 17, and a decrease in graft size at day 24 and 31 in the CSPIO-labeled islet graft. …”

Gene expression in primary human skeletal muscle cells after treatment with acylcarnitines. by Rainer Lehmann (141280)

“…<p>mRNA expression of PGC-1α (A), CPT1b (B), CD36 (C), COX1 (D) and AngPL-4 (E) related to β-actin mRNA levels after incubation with 100 µM L-carnitine (L-C), an equimolar mixture of C8:0-, C10:0- and C12:0-acylcarnitine (total 100 µM; AC), 60 µM palmitate (p), or p and AC as indicated. …”

Effect of galactose treatment on oleic acid metabolism. by Eili Tranheim Kase (177084)

“…Suppressibility, defined as the ability of the cells to decrease oleic acid oxidation by acutely added glucose, was calculated as: [(1-(oxidation of oleic acid at 5 mM glucose/oxidation of oleic acid at no glucose added))×100%]. …”

Anti-HBV activity of CDM-3008 in primary cultured human hepatocytes. by Yutaka Furutani (5620139)

“…(C) Measurement of HBV DNA copies in PXB cells after 7 days of CDM-3008 treatment. HBV DNA was decreased with 0.1–100 μM CDM-3008 in a dose-dependent manner. …”

The effect of ribavirin (Rib) and guanosine (Gua) on HCV infectious progeny production and intracellular viral RNA and nucleotide pools. by Ana M. Ortega-Prieto (446894)

“…(c) Left: intracellular amount of the four nucleoside-triphosphates, following 72 h of exposure to either Rib or Gua, as indicated at the bottom. Right: decrease or increase of nucleotide concentration as a result of exposure to Gua or Rib; note that the maximum decrease possible is 100%. …”

Reliability of the competitive RT-PCR assay for CYP2E1 transcript by Ania Mendoza-Cantú (16382)

“…</p><p>This is an Open Access article: verbatim copying and redistribution of this article are permitted in all media for any purpose, provided this notice is preserved along with the article's original DOI.</p> () A fixed amount of human lymphocyte total RNA (5 μg) was incubated with decreasing amounts of recRNA (lane 1, 1 ng; lane 2, 100 pg; lane 3, 10 pg; lane 4, 1 pg; lane 5, 100 fg; lane 6, 10 fg; lane 7, 1 fg; lane 8, without recRNA. …”

Runx1 attenuates PM proliferation. by Kfir Baruch Umansky (783699)

“…(G) IF analysis of infected PM using anti- Runx1 and MHC Abs (scale bars, 50 μm and 20 μm for x200 or x630 magnification, respectively). …”