Search alternatives:
teer decrease » greater decrease (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), we decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
teer decrease » greater decrease (Expand Search)
nm decrease » nn decrease (Expand Search), _ decrease (Expand Search), we decrease (Expand Search)
a decrease » _ decrease (Expand Search), _ decreased (Expand Search), _ decreases (Expand Search)
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IDD388 Polyhalogenated Derivatives as Probes for an Improved Structure-Based Selectivity of AKR1B10 Inhibitors
Published 2016“…Among the three compounds, only MK204 can make a strong halogen bond with the protein (−4.4 kcal/mol, using QM calculations), while presenting the lowest desolvation cost among all the series, translated into the most selective and inhibitory potency AKR1B10 (IC<sub>50</sub> = 80 nM). …”
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Progesterone decreased Henkel 100-induced responses in a dose-dependent manner in the OE of female mice.
Published 2016“…(E) Relative reduction in peak response to Henkel 100 after progesterone preincubation at different concentrations (0.1 nM: 11.9 ± 2.1% (n = 3), 1 nM: 18.4 ± 3.1% (n = 3), 10 nM: 22.0 ± 11.4% (n = 4), 100 nM: 31.4 ± 7.3% (n = 4), 1 μM: 37.9 ± 2.2% (n = 4), and 10 μM: 48.8 ± 2.1% (n = 4)). …”
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