Linking Protective <i>GAB2</i> Variants, Increased Cortical <i>GAB2</i> Expression and Decreased Alzheimer’s Disease Pathology by Fanggeng Zou (159980)

“…We next measured <i>GAB2</i> mRNA levels in 249 brains and found that decreased neurofibrillary tangle (r = −0.34, p = 0.0006) and senile plaque counts (r = −0.32, p = 0.001) were both good predictors of increased <i>GAB2</i> mRNA levels albeit that sex (r = −0.28, p = 0.005) may have been a contributing factor. …”

Image_2_Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients.jpeg by Emilio Nuñez-Borque (17301673)

“…Extracellular vesicles (EVs) were characterized by Western blot, electron microscopy and NanoSight. A decrease of miR-375-3p levels was determined by qPCR in both serum and EVs of patients with anaphylaxis (****p<.0001). …”

DataSheet_1_Gradually decreasing daylength after smoltification induced by “winter signal“ reduced sexual maturation in male Atlantic salmon.docx by Vetle Skjold (17791562)

“…This initial phase was followed by a grow-out period (1 kg–2.5 kg) in seawater (32-ppt salinity) at 13°C for 11 weeks, with exposure to decreasing daylength. …”

Image_1_Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients.jpeg by Emilio Nuñez-Borque (17301673)

“…Extracellular vesicles (EVs) were characterized by Western blot, electron microscopy and NanoSight. A decrease of miR-375-3p levels was determined by qPCR in both serum and EVs of patients with anaphylaxis (****p<.0001). …”

Image_4_Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients.jpeg by Emilio Nuñez-Borque (17301673)

“…Extracellular vesicles (EVs) were characterized by Western blot, electron microscopy and NanoSight. A decrease of miR-375-3p levels was determined by qPCR in both serum and EVs of patients with anaphylaxis (****p<.0001). …”

Image_3_Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients.jpeg by Emilio Nuñez-Borque (17301673)

“…Extracellular vesicles (EVs) were characterized by Western blot, electron microscopy and NanoSight. A decrease of miR-375-3p levels was determined by qPCR in both serum and EVs of patients with anaphylaxis (****p<.0001). …”

Aquaporin-2 protein and mRNA expression in homogenates of the renal outer medulla. by Lucas H. Oronel (8525697)

Naïve CD8⁺ but not CD4⁺ T cells were significantly decreased in the periphery of Tsc1 KO mice. by Lianjun Zhang (181973)

“…<p>The peripheral T cell subsets of WT and Tsc1 KO mice were detected using FCM 4–5 wks after birth. <b>A.</b> Total thymic cell number and thymocyte subset profile of Tsc1 KO mice were identical as WT littermates. …”

RNA sequencing linkage analysis identifies a single base pair change on Chromosome 25 that is tightly linked to the <i>escapist</i> hypersensitive phenotype. by Elelbin A. Ortiz (8655285)

Shedding of PrP is decreased in PrP^CGPIThy-1 L150 mice but increases after RML infection. by Berta Puig (344828)

“…<p>(A) Representative western blot showing shed PrP (detected with our new antibody described in [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007520#ppat.1007520.ref036" target="_blank">36</a>]) and total PrP levels (detected with POM1). …”

Survivability is decreased in zebrafish embryos following exogenous treatment with an amino-terminal fragment of nApoE4_1-151. by Madyson M. McCarthy (9238322)

Cluster 5—Gene Ontology. by Janaina de Freitas Nascimento (3849415)

“…Furthermore, metacyclics with Pro-Ile and Pro-Val exhibited elevated enzymes linked to lipid and redox metabolism. The results revealed five proteins that were increased and four that were decreased in common in the presence of Pro+BCAAs, indicating their possible participation in key processes related to metacyclogenesis. …”

Population dynamics of <i>Killer-Rescue</i>/Cargo, <i>ClvR</i> and split^50cM <i>ClvR</i> V2. by Georg Oberhofer (3401438)

24 h exposure to 5 by Kelly M. Kennedy (180156)

“…Viable MCF7 cells show significant decreases with 5 mM CHC (A, #p≤0.004 compared to control (no CHC, no lactate + glucose), ‡‡p < 0.01 compared to 40 mM lactate-treated MCF7 cells, *p = 0.003 compared to all no CHC and low CHC groups). …”

NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways. by Zhentao Sheng (107495)

“…<p>(A-B) <i>psid-D1</i> (A) or <i>psid-D4</i> (B) clones in 3rd instar fat body, which were marked by GFP expression (pointed by arrowheads), showed decreased MAPK levels (anti-MAPK staining, red). …”

Constitutively nuclear Foxo1 reduced Na_V1.5 expression. by Weike Mao (181121)

“…<p>Western blots showed that overexpression of Foxo1-AA-GFP for 36 hours reduced Na_V1.5 protein level while it increased endogenous Foxo1 expression (A); quantitiation of Na_V1.5 protein level relative to GAPDH revealed that expression of Foxo1-AA-GFP (n = 5) significantly decreased (*p<0.05, at 10 MOI; **p<0.01 at 50 MOI) Na_V1.5 expression compared with 50 MOI GFP (n = 5) (C). …”

DataSheet_1_Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses.pdf by Chun-Yu Lin (414543)

“…Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. …”

DataSheet_2_Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses.docx by Chun-Yu Lin (414543)

“…Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. …”

Decreases in time from AHP to threshold account for increased firing of cPLA₂α^-/- SCG neurons. by Liwang Liu (424650)

“…<p>(<b>A-B)</b> Examples of differences in AP firing during a 1 sec injection of 100 pA of current. …”

Sanger sequences for CRISPR generated <i>syt7a</i> mutant alleles. by Elelbin A. Ortiz (8655285)