Deficiency of G1 regulators P53, P21and/or pRb decreases hepatocyte sensitivity to TGFβ cell cycle arrest-2 by Sharon Sheahan (38663)

“…As for all experiments the -null hepatocytes were obtained by infection at the time of plating of the hepatocytes of corresponding genotypes with adenovirus expressing Cre recombinase. (1) all deficient hepatocytes respond less well to inhibition of proliferation by TGFβ than control cells and deficient has the strongest effect. (2) and deficiency, singly or together have a similar effect on inhibition of proliferation by TGFβ. (3) deletion significantly reduces TGFβ-induced cell cycle arrest regardless of and status (compare control with ; - with with - and with TRPL). (4) double deficiency in and further decreases hepatocytes responses to TGFβ in term of regulation of proliferation, independently of status. (5) by contrast the effect of TGFβ on hepatocytes deficient in both and is not significantly different to that of null cells, and this is independent of status. …”

Data_Sheet_1_Repeated Inoculation of Young Calves With Rumen Microbiota Does Not Significantly Modulate the Rumen Prokaryotic Microbiota Consistently but Decreases Diarrhea.docx by Dengpan Bu (369549)

DataSheet_1_Novel mediator in anaphylaxis: decreased levels of miR-375-3p in serum and within extracellular vesicles of patients.docx by Emilio Nuñez-Borque (17301673)

“…Extracellular vesicles (EVs) were characterized by Western blot, electron microscopy and NanoSight. A decrease of miR-375-3p levels was determined by qPCR in both serum and EVs of patients with anaphylaxis (****p<.0001). …”

Datasheet1_Quality of life, exercise capacity, cognition, and mental health of Chilean patients after COVID-19: an experience of a multidisciplinary rehabilitation program at a phy... by Valeria Paéz (17523354)

“…Moreover, physical therapy led to a reduction in neuropathic symptoms and pain, psychological therapy reduced anxiety and depression, and language therapy enhanced memory and speech (all p < 0.05). (3) Demographic and clinical history characteristics did not predict responses to rehabilitation. (4) A regression model for predicting changes in SF-36 total score, based on physical function, physical role, general health, and mental health, was established based on the data from study (p < 0.01, adjusted R² = 0.893). (5) Classification models for predicting dropouts achieved 68% accuracy, with key predictors of treatment adherence including diabetes, hypertension, and dyslipidemia, Tinetti balance, physical role, and vitality of SF36, and performance on the 6-minute walk test and 1-minute sit-to-stand.…”

Time series trends showing predicted six-month retention for cohorts enrolled in each month from January 2015 through December 2018 comparing pre-UTT (2015–2016) and UTT (2017–2018... by Levicatus Mugenyi (6393749)

Oncostatin M Mediates STAT3-Dependent Intestinal Epithelial Restitution via Increased Cell Proliferation, Decreased Apoptosis and Upregulation of SERPIN Family Members by Florian Beigel (174724)

Image_5_A study of dynamic hand orthosis combined with unilateral task-oriented training in subacute stroke: A functional near-infrared spectroscopy case series.TIF by ChaoJinZi Li (13232019)

“…After the intervention, the activation of bilateral hemispheres decreased but in different brain regions; there was a trend that the activation intensity of left sensorimotor cortex, right premotor cortex, and right prefrontal cortex decreased while activation intensity of left premotor cortex and left prefrontal cortex increased. …”

Table_5_A metabolome genome-wide association study implicates histidine N-pi-methyltransferase as a key enzyme in N-methylhistidine biosynthesis in Arabidopsis thaliana.xlsx by Kai Uchida (16076942)

Datasheet1_Polo-like kinase (PLK) 5, a new member of the PLK family, serves as a biomarker to indicate anabatic tumor burden and poor prognosis for resectable non-small cell lung c... by Kaichao Wang (14335569)

“…Objective<p>A review argues that polo-like kinase 5 (PLK5) may be linked to unfavorable prognosis in non-small cell lung cancer (NSCLC) patients, which contradicts the discoveries from The Human Protein Atlas database (derived from TCGA analysis). …”

<i>In vitro</i> characterization of escape mutant viruses of anti-HA stalk antibody candidate clone F11. by Kaori Sano (229641)

“…Although association of the G480D mutated virus (G6) decreased (ka [1/Ms] = 8.631 × 105), dissociation remained relatively low (kd (1/s) = 1.306 × 10–5) when compared with that for wild-type HA.…”

Data_Sheet_1_The role of booster vaccination in decreasing COVID-19 age-adjusted case fatality rate: Evidence from 32 countries.docx by Cui Zhou (1388874)

Impact of Heat Stress on Cellular and Transcriptional Adaptation of Mammary Epithelial Cells in Riverine Buffalo (<i>Bubalus Bubalis</i>) by Neha Kapila (3183045)

“…The upregulated genes in heat stressed MECs belonged to heat shock family <i>viz</i>., HSPA6, HSPB8, DNAJB2, HSPA1A. Along with HSPs, genes like BOLA, MRPL55, PFKFB3, PSMC2, ENDODD1, ARID5A, and SENP3 were also upregulated. …”

Clinical characteristics of the study population. by Hun Gi Lee (21526538)

“…The proportions of emergency surgeries (46.5%), ICU admissions (36.5%), and unfavorable outcomes (21.5%) decreased. …”

Image_1_An Appraisal of the Influence of the Metabotropic Glutamate 5 (mGlu5) Receptor on Sociability and Anxiety.TIF by Arnau Ramos-Prats (6374159)

“…However, in normal wild-type (WT) mice, pharmacological blockade of mGlu5 receptors yielded inconsistent results. …”

Model for the role of CCR5 dimerization in gp120 binding. by Philippe Colin (128052)

“…Equilibrium arrows in <b>A</b> and <b>B</b> show that the proportion of dimers is decreased in the case of L196K-CCR5, as compared to WT-CCR5.…”

Low levels of platelet-specific transcripts in leukocytes can be due to platelet-leukocyte interactions. by Heather Learnard (22075952)

Fig 1 - by Fatemeh Mohammadkhani (15927311)

Supplementary Material for: Pregnane-Oximino-Alkyl-Amino-Ether Compound as a Novel Class of TGR5 Receptor Agonist Exhibiting Antidiabetic and Anti-Dyslipidemic Activities by Gupta J. (11745866)

“…These beneficial effects of compound <b>14b</b> were associated with the activation of the G-protein-coupled bile acid receptor TGR5. <b><i>Conclusion:</i></b> Compound <b>14b</b> exhibits antidiabetic and anti-dyslipidemic activities through activating the TGR5 receptor system and can be developed as a lead for the management of type II diabetes and related metabolic complications.…”

AZ3451 and PD98059 reduced the intestinal IIL and adult worm burden at 12 h and 5 d post infection. by Lu Lu Han (4759488)

Weed flora composition of the experimental site. by Fatemeh Mohammadkhani (15927311)

“…In most intercropping ratios, weed density and weed biomass decreased under one-time irrigation regimes. The lowest values for weed density and biomass were observed with an average of 15.5 plants/m² and 37.51 g/m², respectively, under the one-time irrigation regime with C4 intercropping systems. …”