Regulatory T Cell Responses in Participants with Type 1 Diabetes after a Single Dose of Interleukin-2: A Non-Randomised, Open Label, Adaptive Dose-Finding Trial by John A. Todd (5933)

“…Furthermore, there was a dose-dependent down modulation of one of the two signalling subunits of the IL-2 receptor, the β chain (CD122) (mean decrease = 58.0%, SE = 2.8%, range 9.8%–85.5%, <i>n</i> = 33), on Tregs and a reduction in their sensitivity to aldesleukin at 90 min and day 1 and 2 post-treatment. …”

Pediatric Ocular Rosacea: Clinical Features and Long-Term Maintenance Therapy with Topical Cyclosporine by Gamze Özkan (22130419)

“…Delayed diagnosis was present in 10 patients, with a mean delay duration of 10.0 ± 2.7 months. Two patients showed recurrence and mean recurrence time was 6.50 ± 2.50 months. …”

Supplementary Material for: Clinical and Pathophysiologic Insights of Free triiodothyronine/Free thyroxine Ratio in Patients with Heart Failure with Preserved Ejection Fraction: Da... by Leite A.R. (9097394)

“…Lower FT3/FT4 ratio was associated with higher risk for the composite HF outcome (HR = 2.50, 95% CI: 1.04–5.88, per 1-unit decrease in FT3/FT4, <i>p</i> = 0.041). …”

Effect of appetite suppressants on head-weaving stereotypy in female rats. by Axl Lopez (21594203)

“…For example, the subjects represented by the red dot showed increasing levels of stereotypy over the days, whereas the subjects represented by the cyan dot transitioned from high levels of stereotypy during the first days of treatment to levels below the mean on days 6 and 7 of treatment. <b>F)</b> d-amphetamine (10 mg/kg): From the first day of treatment, subjects exhibited a level above 50% of time spent on stereotypy, which slightly increased on the second day. …”

Impact of Oral Semaglutide on Kidney Outcomes in People with Type 2 Diabetes: Results from the SOUL Randomized Trial by Johannes F. E. Mann (22017555)

“…Prespecified kidney outcomes included a 5-point composite (≥50% decrease in estimated glomerular filtration rate [eGFR], persistent eGFR <15 mL/min/1.73 m2, initiation of chronic kidney replacement therapy, or death from kidney or CV causes); a 4-point composite (excluding CV death); and eGFR decline. …”

Layer-specific quantification of RS and FS neuronal activity in wM2 across learning. by Vahid Esmaeili (12700352)

“…Left: baseline-subtracted (50 ms prior to whisker onset) population firing rate (mean ± SEM) for different cortical layers (L2/3, L5, and L6a) overlaid for Novice mice (244 neurons in 7 mice) and Expert mice (401 neurons in 11 mice). …”

Supplementary Material for: Clinical and Pathophysiologic Insights of Free triiodothyronine/Free thyroxine Ratio in Patients with Heart Failure with Preserved Ejection Fraction: Da... by Leite A.R. (9097394)

“…Lower FT3/FT4 ratio was associated with higher risk for the composite HF outcome (HR = 2.50, 95% CI: 1.04–5.88, per 1-unit decrease in FT3/FT4, <i>p</i> = 0.041). …”

Linaclotide in Chronic Idiopathic Constipation Patients with Moderate to Severe Abdominal Bloating: A Randomized, Controlled Trial by Brian E. Lacy (776932)

“…Approximately one-third of linaclotide patients (each group) had ≥50% mean decrease from baseline in abdominal bloating vs. 18% of placebo patients (<i>P</i><0.01). …”

Data_Sheet_1_Secular Difference in Body Mass Index From 2014 to 2020 in Chinese Older Adults: A Time-Series Cross-Sectional Study.docx by Ying Jiang (5910)

“…Both the increase of BMI (overweight and obesity) and decrease of BMI (underweight) has been associated with high risk of adverse outcome, such as stroke, disability, and even death. …”

Data Sheet 1_Comparison of trend analysis of varicella zoster disease burden between China and the world 1990–2021 and disease burden forecast 2030.csv by Zhichun Chang (18594517)

“…Projections suggest a slight decrease in the VZV burden in China by 2030. …”

Table1_Effects of 3-week repeated cold water immersion on leukocyte counts and cardiovascular factors: an exploratory study.docx by Ninja Versteeg (16894872)

“…</p><p>Results: Total leukocyte count decreased in CWI (p = 0.027, 95% CI −2.35 to −0.20 × 10³/µL) and CON (p = 0.043, 95% CI −2.75 to −0.50 × 10³/µL). …”

Development and characterization of a bivalent mRNA vaccine targeting the Delta and Omicron variants of SARS-CoV-2 by Xiao-Chuan Xiong (22337097)

“…Then, the immunogenicity of the vaccine candidates under a two-dose prime immunization regimen were further analyzed, demonstrating that ARCoV-Biv induced a broad neutralizing antibody response, with mean neutralization titers (NT50) of 87,556.33 against Delta (B.1.617.2) and 52,634.67 against Omicron BA.1, representing 71.19-fold and 399.72-fold increases, respectively, compared to the levels prior to booster immunization. …”

Dephosphorylation of AMPK by PP2A phosphatase promotes neuritogenic effect of SIM in SH-SY5Y cells. by Varshiesh Raina (457377)

“…Error bar graph shows the difference in neurite length between SIM, SIM + Fostriecin and SIM + AICAR treated cells for 12 hrs (mean ± SEM; N = 50 cells per condition from 3 separate cultures). …”

Table_1_A gaming app developed for vestibular rehabilitation improves the accuracy of performance and engagement with exercises.DOCX by Linda J. D’Silva (17444991)

“…Vestibular rehabilitation is the gold standard recommendation to decrease symptoms and improve postural stability. The Clinical Practice Guidelines for vestibular hypofunction suggest home exercises 3–5 times daily, but patient adherence is a problem, with compliance rates often below 50%.…”

(A) Effect of calcium chelators and K channel antagonist, ChTX on fEPSP during OGD. by Shirin Jalini (2551054)

“…EGTA-AM (50μM) shows similar effects to BAPTA-AM (1μM) by decreasing time needed for electrophysiological recovery after 4 min of OGD (n = 6) but not after 6 min (n = 7). …”

datasheet1_Efficacy and Safety of Immunosuppressive Monotherapy Agents for IgA Nephropathy: A Network Meta-Analysis.docx by Shisheng Han (10019855)

“…Relative risks (RRs) or standard mean differences with 95% confidence intervals (CIs) were estimated using the random-effects model. …”

KRIT1 regulates steady-state levels of intracellular ROS. by Luca Goitre (245127)

“…Representative flow cytometry profiles (C,E,G) and quantitative histograms of the mean fluorescence intensity (M.F.I.) values (D,F,H) of n≥5 independent FACS experiments are shown. …”

ATF4 knockdown in P30 T17M photoreceptors has a positive influence on the RHO expression machinery (N = 4 for all groups). by Yogesh Bhootada (408443)

“…ONL, outer nuclear layer; IS, Inner segments; OS, outer segments. Scale bar indicates 50 mm. The data are presented as mean ± SEM. See also <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0154779#pone.0154779.s004" target="_blank">S1 Table</a> for details.…”

Expression of <i>FMRFaR</i>^<i>RNAi</i> in dopaminergic neurons reduces membrane depolarization. by Preethi Ravi (5634665)

“…(D) Representative images of neuronal depolarization as observed by a decrease in Arclight fluorescence in the same genotypes shown in (A). …”

Exclusion criteria. by Yuta Miyazaki (1743460)

“…The coefficient of determination (R²) and root mean square error (RMSE) values were compared between the actual and predicted discharge FIM scores and FIM gain.…”