Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”

S10 Data - by Christoph Anders (4068499)

“…The study was conducted with 25%, 50%, and 75% of the upper body weight. Additionally, we varied the starting point (forward tilt and backward tilt) and the direction of rotation. …”

Fig 10 - by Sana Khalid (132742)

Appearance of standards under UV 365 nm. by Asif Khan (1740271)

JBPOS0101 decreased Amyloid Beta (Aβ) aggregates in the cortex and hippocampal regions in 5xFAD mouse brains. by Jihoon Jeong (4852690)

Taste sensilla in the wing and RNA-seq screen of control and <i>Poxn</i> wings. by Zhe He (508742)

Leg and wing <i>IR52a</i>^<i>+</i> neurons form functional connections with neurons in the SEZ. by Zhe He (508742)

Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Multi-way sensitivity analysis on transmission rate, CD4 count at diagnosis, and ART costs in a model-based analysis of Immediate ART initiation in Côte d’Ivoire. by Eric N. Ouattara (6890174)

Can inoculation with diazotrophic bacteria decrease the productivity loss of defoliated Vigna unguiculata (L.) Walp? by Caliane da S. Braulio (10469226)

FG-2216 decreased plasma markers of cardiac injury in Nx-Ob-ZSF1 rats. by Pierre E. Signore (11218497)

Small RNR subunit interaction with Ydj1 is decreased in Ssa3 and Ssa4 cells. by Laura E. Knighton (5991239)

High-Reflectivity Force-Chromic Photonic Crystal Elastic Materials Based on Nanospheres within an Elastomer for Applications in Sensing and Textile Fields by Zhichuang Qi (20539399)

“…Due to the absence of solvents in the elastic system, the FPE has excellent stability, and the structural color remains unchanged under 50 stretch/release cycling experiments. This FPE not only has a simple preparation method, fast response, high reflectivity, and good stability, but we have found through validation experiments that it has great potential in the fields of sensing, signal transmission, and smart textiles.…”

High-Reflectivity Force-Chromic Photonic Crystal Elastic Materials Based on Nanospheres within an Elastomer for Applications in Sensing and Textile Fields by Zhichuang Qi (20539399)

“…Due to the absence of solvents in the elastic system, the FPE has excellent stability, and the structural color remains unchanged under 50 stretch/release cycling experiments. This FPE not only has a simple preparation method, fast response, high reflectivity, and good stability, but we have found through validation experiments that it has great potential in the fields of sensing, signal transmission, and smart textiles.…”

High-Reflectivity Force-Chromic Photonic Crystal Elastic Materials Based on Nanospheres within an Elastomer for Applications in Sensing and Textile Fields by Zhichuang Qi (20539399)

“…Due to the absence of solvents in the elastic system, the FPE has excellent stability, and the structural color remains unchanged under 50 stretch/release cycling experiments. This FPE not only has a simple preparation method, fast response, high reflectivity, and good stability, but we have found through validation experiments that it has great potential in the fields of sensing, signal transmission, and smart textiles.…”

MPA induced cell proliferation in CAFs of obese women by decreasing the expression of stromal differentiation genes. by Intan Sofia Omar (10451088)

TBEV-induced translational arrest results in the decreased protein levels of GAPDH, HPRT1, and viperin. by Martin Selinger (3195987)

Impaired Ubr5 function results in increased canonical and decreased non-canonical HH signalling. by David Mellis (2833469)

Minimum, maximum, and mean horizontal and diagonal FID for the different species. Upper 95% confidence intervals were calculated from the mean. The minimum and maximum distances fo... by Estefania Velilla (22566709)

Excision of HIF1α decreases viral reactivation from latency in infected splenocytes in vivo. by Darlah M. López-Rodríguez (8098544)