Discovery of IHMT-MST1-58 as a Novel, Potent, and Selective MST1 Inhibitor for the Treatment of Type 1/2 Diabetes by Yun Wu (150224)

“…Mammalian STE20-like protein 1 kinase (MST1) plays vital roles in the apoptosis and insulin secretion of β cells. Here, we discovered a novel, potent, and selective MST1 inhibitor <b>19</b> (IC₅₀ = 23 nM), which inhibited the phosphorylation of MST1-protected β cells from the damage of inflammatory cytokines in vitro. …”

Data_Sheet_1_Long-term effects of the gait treatment using a wearable cyborg hybrid assistive limb in a patient with spinal and bulbar muscular atrophy: a case report with 5 years... by Kensuke Iijima (16076471)

“…Thus, this study aimed to investigate the long-term effects of the continued gait treatment with HAL in a patient with SBMA.</p>Results<p>A 68-year-old man with SBMA had lower limb muscle weakness and atrophy, gait asymmetry, and decreased walking endurance. …”

Supplementary Material for: microRNA-29a-3p, Up-Regulated in Human Gastric Cells and Tissues with <b><i>H.Pylori</i></b> Infection, Promotes the Migration of GES-1 Cells via A20-Me... by Sun F. (6017897)

Physiological Markers of Arousal Change with Psychological Treatment for Insomnia: A Preliminary Investigation by Christopher B. Miller (838716)

“…</p><p>Methods</p><p>In a pre-to-post open label study design, eleven patients with chronic and severe Psychophysiological Insomnia underwent 5 weeks of Sleep Restriction Therapy.…”

Positive (+) and negative (-) impacts of the Covid-19 pandemic on new mothers in the Covid-19 New Mum Study. by Adriana Vázquez-Vázquez (9672972)

Primers used in this study. by Hadi Alizadeh (20854757)

“…The overexpression of AGPAT3 in A2780 cells led to increased p-mTOR/mTOR and p-S6K/S6K ratios and increased IC50 values, as shown by RT-qPCR, western blotting, and MTT analysis. …”

Long-term successive biochar application increases plant lignin and microbial necromass accumulation but decreases their contributions to soil organic carbon in rice–wheat cropping... by Zhaoming Chen (18173249)

Linear covariate analysis of prognostically significant metabolites. Presenting the effect sizes of metabolites that showed significant differences among prognostic groups in ICU-treated COVID-19 patients. Metabolites were included based on an F-value > 2.5 and a p-value < 0.05. Metabolites marked with a single asterisk (*) were significant in both two-way ANOVA and ASCA, whereas those marked with double asterisks (**) were significant only in two-way ANOVA.... by Emir Matpan (21655811)

“…Metabolites were included based on an F-value > 2.5 and a p-value < 0.05. Metabolites marked with a single asterisk (*) were significant in both two-way ANOVA and ASCA, whereas those marked with double asterisks (**) were significant only in two-way ANOVA. …”

Results from experiment 3, 4 and 5. by Olivia Carter (194606)

Pan-JAK inhibitor P6 decreased ISG expression and increased susceptibility of BEAS-2B cells to H1N1 influenza virus infection. by Lai-Giea Seng (644370)

“…BEAS-2B cells were pre-treated with P6 at a final concentration of 2.5 or 5 µM for 24 h and infected with H1N1 influenza virus at 1.0 MOI (based on MDCK cells). …”

Data_Sheet_1_Complex CDKL5 translational regulation and its potential role in CDKL5 deficiency disorder.PDF by Valeria Ruggiero (631884)

“…A decrease in its expression or activity leads to a severe neurodevelopmental condition known as CDKL5 deficiency disorder (CDD). …”

Data_Sheet_2_Complex CDKL5 translational regulation and its potential role in CDKL5 deficiency disorder.pdf by Valeria Ruggiero (631884)

“…A decrease in its expression or activity leads to a severe neurodevelopmental condition known as CDKL5 deficiency disorder (CDD). …”

Fig 6 - by Kellie J. Walters (10451329)

Fig 1 - by Kellie J. Walters (10451329)

Fig 3 - by Kellie J. Walters (10451329)

Fig 8 - by Kellie J. Walters (10451329)

Temporal composition by bacterial phyla (A) and families (B) in treated eyes. by Joshua E. Darden (7490387)

Fig 2 - by Kellie J. Walters (10451329)

Fig 7 - by Kellie J. Walters (10451329)

Altered cell cycle timing in <i>yhp1-13A yox1-9A</i> cells. by Michelle M. Conti (13514386)