RNA sequencing linkage analysis identifies a single base pair change on Chromosome 25 that is tightly linked to the <i>escapist</i> hypersensitive phenotype. by Elelbin A. Ortiz (8655285)

Shedding of PrP is decreased in PrP^CGPIThy-1 L150 mice but increases after RML infection. by Berta Puig (344828)

“…<p>(A) Representative western blot showing shed PrP (detected with our new antibody described in [<a href="http://www.plospathogens.org/article/info:doi/10.1371/journal.ppat.1007520#ppat.1007520.ref036" target="_blank">36</a>]) and total PrP levels (detected with POM1). …”

Survivability is decreased in zebrafish embryos following exogenous treatment with an amino-terminal fragment of nApoE4_1-151. by Madyson M. McCarthy (9238322)

Cluster 5—Gene Ontology. by Janaina de Freitas Nascimento (3849415)

“…Furthermore, metacyclics with Pro-Ile and Pro-Val exhibited elevated enzymes linked to lipid and redox metabolism. The results revealed five proteins that were increased and four that were decreased in common in the presence of Pro+BCAAs, indicating their possible participation in key processes related to metacyclogenesis. …”

Population dynamics of <i>Killer-Rescue</i>/Cargo, <i>ClvR</i> and split^50cM <i>ClvR</i> V2. by Georg Oberhofer (3401438)

24 h exposure to 5 by Kelly M. Kennedy (180156)

“…Viable MCF7 cells show significant decreases with 5 mM CHC (A, #p≤0.004 compared to control (no CHC, no lactate + glucose), ‡‡p < 0.01 compared to 40 mM lactate-treated MCF7 cells, *p = 0.003 compared to all no CHC and low CHC groups). …”

NatB inactivation decreased the level of MAPK and proposed model of EGFR/MAPK signaling regulation by NatB and the N-end rule pathways. by Zhentao Sheng (107495)

“…<p>(A-B) <i>psid-D1</i> (A) or <i>psid-D4</i> (B) clones in 3rd instar fat body, which were marked by GFP expression (pointed by arrowheads), showed decreased MAPK levels (anti-MAPK staining, red). …”

Constitutively nuclear Foxo1 reduced Na_V1.5 expression. by Weike Mao (181121)

“…<p>Western blots showed that overexpression of Foxo1-AA-GFP for 36 hours reduced Na_V1.5 protein level while it increased endogenous Foxo1 expression (A); quantitiation of Na_V1.5 protein level relative to GAPDH revealed that expression of Foxo1-AA-GFP (n = 5) significantly decreased (*p<0.05, at 10 MOI; **p<0.01 at 50 MOI) Na_V1.5 expression compared with 50 MOI GFP (n = 5) (C). …”

DataSheet_1_Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses.pdf by Chun-Yu Lin (414543)

“…Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. …”

DataSheet_2_Mono-(2-ethylhexyl) phthalate Promotes Dengue Virus Infection by Decreasing IL-23-Mediated Antiviral Responses.docx by Chun-Yu Lin (414543)

“…Among 89 DV-infected patients, those with DV infection-related gastrointestinal (GI) bleeding (n = 13, 15% of patients) had significantly higher DEHP exposure than those without GI bleeding (n = 76, 85% of patients), which were 114.2 ng/ml versus 52.5 ng/ml ΣDEHP in urine; p = 0.023). In an in vitro study using cultured human monocyte-derived macrophages (MDMs) to investigate the effects of MEHP, treatment increased IL-1β and TNF-α release but decreased IL-23 release, with negative correlations observed between urine ΣDEHP and serum IL-23 levels in patients. …”

Decreases in time from AHP to threshold account for increased firing of cPLA₂α^-/- SCG neurons. by Liwang Liu (424650)

“…<p>(<b>A-B)</b> Examples of differences in AP firing during a 1 sec injection of 100 pA of current. …”

Sanger sequences for CRISPR generated <i>syt7a</i> mutant alleles. by Elelbin A. Ortiz (8655285)

Image_5_Epidemiological and Clinical Characteristics of Five Rare Pathological Subtypes of Hepatocellular Carcinoma.pdf by Xiaoyuan Chen (322516)

“…This study aimed to describe the epidemiological and clinical spectrum of five rare HCC subtypes and develop a competing risk nomogram for cancer-specific survival prediction.…”

Opportunistic analysis of clinically actionable DPYD gene variants in a germline testing cohort in India by Rajdeep Raha (22056304)

“…Comparative allele frequency analysis was performed using global population datasets to identify inter-population differences.</p> <p>A total of 95 individuals (5.3%) carried at least one decreased or no function DPYD variant, indicating a significant prevalence of clinically actionable genotypes in this Indian cohort. …”

Supplementary file 1_Intercropping of short- and tall-stature maize decreases lodging risk without yield penalty at high planting density.docx by Jianhong Ren (2186293)

“…Thus, we aimed to coordinate grain yield and lodging resistance of maize under high planting density by intercropping short-stalked Zhengdan958 (ZD) with tall-stalked Xianyu335 (XY). Five planting systems were conducted, i.e. SZD: sole Zhengdan 958 at normal density (7.5 plants m^-2); SXY and SHXY: sole Xianyu 335 at normal and high density (9.0 plants m^-2); IND and IHD: normal density ZD intercropped with normal and high density XY, respectively. …”

H-MSCs^WT reduced infarct size and collagen I expression 7 days post-MI. by Panpan Chen (307628)

Design and Synthesis of Novel Spiro Derivatives as Potent and Reversible Monoacylglycerol Lipase (MAGL) Inhibitors: Bioisosteric Transformation from 3‑Oxo-3,4-dihydro‑2<i>H</i>‑ben... by Shuhei Ikeda (2380180)

“…Optimization of the left hand side afforded <b>4f</b> as a promising reversible MAGL inhibitor, which showed potent in vitro MAGL inhibitory activity (IC₅₀ 6.2 nM), good oral absorption, blood–brain barrier penetration, and significant pharmacodynamic changes (2-arachidonoylglycerol increase and arachidonic acid decrease) at 0.3–10 mg/kg, po. in mice.…”

Exome-Sequencing Confirms <em>DNAJC5</em> Mutations as Cause of Adult Neuronal Ceroid-Lipofuscinosis by Bruno A. Benitez (197732)

“…A novel single-nucleotide variation (c.344T>G) in the <em>DNAJC5</em> gene was identified. …”

Outstanding impact of Azospirillum brasilense strains Ab-V5 and Ab-V6 on the Brazilian agriculture: Lessons that farmers are receptive to adopt new microbial inoculants by Mariana Sanches Santos (10378494)

“…Brazil has a long tradition in the use of rhizobial inoculants, especially for the soybean crop, but it was only in 2009 that the first commercial inoculant carrying the plant-growth-promoting Azospirillum brasilense strains Ab-V5 (=CNPSo 2083) and Ab-V6 (=CNPSo 2084), identified by our research group, reached the market. …”

Transcriptomic and metabolomic analyses of liver of <i>Fmo5</i>^<i>-/-</i> and WT mice. by Ian R. Phillips (5074121)

“…Red dots are genes whose expression is significantly increased or decreased in <i>Fmo5</i>^<i>-/-</i> mice with a -log₁₀ <i>q</i> above 1.301 (<i>q</i> <0.05) (grey line). …”