Exposure to the Viral By-Product dsRNA or Coxsackievirus B5 Triggers Pancreatic Beta Cell Apoptosis via a Bim / Mcl-1 Imbalance by Maikel L. Colli (179059)

“…We have presently clarified the signaling pathways leading to beta cell apoptosis following exposure to the viral mimetic double-stranded RNA (dsRNA) and a diabetogenic enterovirus (Coxsackievirus B5). …”

PPM1A directly dephosphorylates STING and TBK1 and prevents STING aggregation. by Zexing Li (713843)

“…HEK293 cells were transfected with Flag-TBK1 (0.5 μg) along with empty vector (2 μg) or HA-PPM1A-WT or HA-PPM1A-R174G (2 μg), and 24 h later, cell lysates were immunoprecipitated with anti-Flag beads. …”

Impact of iso-osmotic solutions of PEG 12.9%, NaCl 75 mM or mix treatment (PEG 6.4% + NaCl 37.5 mM) applied for 1 or 7 days on net photosynthesis (<i>A</i>), instantaneous transpir... by Hermann Prodjinoto (140121)

Data_Sheet_1_NLRC5 Serves as a Pro-viral Factor During Influenza Virus Infection in Chicken Macrophages.docx by Shubhada K. Chothe (8678763)

“…In this study, we found that NLRC5 is activated by a range of low and highly pathogenic AIVs in primary chicken lung cells and a chicken macrophage cell line. …”

NoV polymerase and capsid genotypes. by Ange Oho Roseline Badjo (18991158)

“…We identified rare genotypes of NoV GII, RVA and HAstV, recombinant HAstV strains and a potential zoonotic RVA transmission event.…”

Delays throughout the care cascade. by Lavanya Huria (12488093)

“…For instance, in Indonesia, a high TB burden country, TB case notifications decreased by 14% and treatment coverage decreased by 47% during COVID-19. …”

ECRG4 regulates neutrophils migration to chemoattractants. by Katie D. Pool (20141584)

Figure 5, supplementary figure 7 by Kristen Pleil (11084931)

“…</b>a-d) Analysis of single nucleus RNA sequencing of female BNST nuclei (total cells: 38,806; GEO: GSE126836)⁷⁸. a) <i>Crh</i> (CRF) expression (7.7%) in female BNST cells. b) <i>Slc117a6</i> (VGLUT2) expression (7.6%) in female BNST cells. c) <i>Gfap</i> (GFAP) expression (0.7%) in female BNST cells. d) ERα (27%) and ERβ (9%) expression (5% both) in female BNST^GFAP cells. e-f) Effects of acute bath application of the ERα antagonist methyl-piperidino-pyrazole (MPP) on excitatory synaptic transmission in BNST^CRF neurons during whole-cell slice electrophysiology recordings in high ovarian E2 female CRF-CrexAi9 reporter mice, as depicted in e. f) Time course of high E2 status BNST^CRF neurons that displayed an increase, decrease, or variable change in spontaneous excitatory postsynaptic current (sEPSC) frequency (left) and amplitude (right) % change from baseline during the 5-minute MPP wash on application period and 5 minute washout. g-i) Effects of acute bath application of MPP on excitatory synaptic transmission in BNST^CRF neurons during whole-cell slice electrophysiology recordings in low ovarian E2 female CRF-CrexAi9 reporter mice, as depicted in g. f) Time course of low E2 status BNST^CRF neurons that displayed an increase, decrease, or variable change in spontaneous excitatory postsynaptic current (sEPSC) frequency (left) and amplitude (right) % change from baseline during the 5-minute MPP wash on application period and 5 minute washout. i) Bath application of MPP (3 μM) had no effect on spontaneous excitatory postsynaptic current (sEPSC) frequency (left) and amplitude (right) in a majority of cells during the 5 min wash on period (Ns = 3 mice, 7 cells). j) Depiction of strategy to site-deliver MPP (10 μM/200 nl/side or saline vehicle (VEH) to the BNST in low E2 females via bilateral indwelling cannulae 10 minutes prior to behavioral testing. k) ERα antagonism via intra-BNST MPP did not alter binge EtOH drinking in low ovarian E2 status females (Ns = 8 VEH, 8 MPP). l) BNST cannula hit map (for Fig. 4d-e, 5j-l); each dot is an individual hit. …”

Changes in work exposure as a function of relative time for seven fixed values of mean exposure. by Danuta Roman-Liu (8532645)

Voxel representation of a 3D binary image (left) and its corresponding graph of connected pore space voxels (right). by Mouad Klai (20818364)

Identification of 5-FU-sensitizing genes. by Tomohiko Sakabe (282459)

“…<p>(A) Determination of a 5-FU concentration sufficient to decrease cell viability in HepG2 cells, which were treated with various concentrations of 5-FU for 72 h. …”

Effects of Y-P30 on expression and phosphorylation of glutamate receptors, Src, and ERK. by Janine R. Neumann (6330863)

“…Note that p42/p44 ERK and c-Src phosphorylation were increased at DIV 5 and DIV 10. By contrast, at DIV 20, p42/p44 ERK was no longer activated, and Y418 c-Src and Y1472 GluN2B phosphorylation were decreased at 15 and at 60 min; Mann-Whitney U test p values given in (A). …”

Chemical and siRNA-mediated inhibition of catalase activity in A549 cells enhances the cytotoxic effects of heme. by Lilibeth Lanceta (782925)

Immunostaining patterns of 5-mC and 5-hmC in normal glandular epithelium and adenocarcinoma in situ (AIS). by Jobran M. Moshi (18405149)

“…Note the dramatic decrease in 5-hmC immunofluorescence in the AIS structures (gland 1 normal columnar epithelium, glands 2 and 3 containing AIS structures). …”

<i>Gli3</i> is a negative regulator of <i>Tas1r3</i>-expressing taste cells by Yumei Qin (1755145)

“…Conditional knockout mice lacking <i>Gli3</i> in the posterior tongue (<i>Gli3</i>^<i>CKO</i>) had larger taste buds containing more taste cells than did control wild-type (<i>Gli3</i>^<i>WT</i>) mice. In comparison to wild-type mice, <i>Gli3</i>^<i>CKO</i> mice had more <i>Lgr5</i>+ and <i>Tas1r3</i>+ cells, but fewer type III cells. …”

A model with two target-cell populations and viral competition in one of these populations matches <i>in vivo</i> data and predicts that R5 inhibitors accelerate AIDS onset. by Ariel D. Weinberger (169848)

“…(D) Time-dependency of X4 emergence as a function of CCR5 inhibitor efficacy (α-CCR5 efficacy) in the “competitive regime.” …”

CMR, CATH, CFD, and LP data for the left and right lungs, comparing (a) mean indexed flow rates and (b) mean pressures. by Sebastian Laudenschlager (19233101)

Image 5_Photon budgets and the relative effects of CDOM and pigment absorptions on primary production along a coastal salinity gradient.jpeg by Aleksandr Berezovski (20548583)

“…By examining the effects of these components across different seasons, we aimed to elucidate their relative contributions to light absorption and PP. …”

Primers sequences for qRT-PCR. by Peiguang Niu (17044532)

“…Free fatty acids (FFA) was measured by fluorescence using acyl-CoA oxidation and carnitine palmitoyl transferase-1 (CPT-1) activity was analyzed by spectrophotometric assay using palmitoyl-CoA and DTNB (5,5’-dithio-bis-(2-nitrobenzoic acid)) reaction. mRNA expression was measured by Quantitative Real-Time PCR. …”

Original western blotimages. by Peiguang Niu (17044532)

“…Free fatty acids (FFA) was measured by fluorescence using acyl-CoA oxidation and carnitine palmitoyl transferase-1 (CPT-1) activity was analyzed by spectrophotometric assay using palmitoyl-CoA and DTNB (5,5’-dithio-bis-(2-nitrobenzoic acid)) reaction. mRNA expression was measured by Quantitative Real-Time PCR. …”