Missense Variant in MAPK Inactivator <i>PTPN5</i> Is Associated with Decreased Severity of Post-Burn Hypertrophic Scarring by Ravi F. Sood (263139)

“…</p><p>Results</p><p>Our study population consisted of 538 adults (median age 40 years) who were predominantly White (76%) males (71%) admitted to our center from 2007–2014 with small-to-moderate-sized burns (median burn size 6% total body surface area). Of 2,146 SNPs tested, a rare missense variant in the <i>PTPN5</i> gene (rs56234898; minor allele frequency 1.5%) was significantly associated with decreased severity of post-burn HTS (<i>P</i> = 1.3×10⁻⁶). …”

Panel probit models: Dummy variable which takes a value of 1 for a top 5 publication. by Sergey V. Popov (6719075)

After 16 weeks of high-cholesterol diet, TSLPR, CD62, and CD63 expression on platelet surface were not significantly different between the HCD, T1 (ticagrelor 25 mg/kg/d), and T2 (... by Yi Mao (815954)

Theme 5 results—mortality. by Corey J. A. Bradshaw (8032406)

Therapeutic effects of miR-150-5p inhibition on atherosclerotic lesion development. by Ping-yu Cai (12389929)

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Empirical Bayes estimates of parameter <i>μ</i>. by Guillaume Lingas (9955528)

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Model building procedure. by Guillaume Lingas (9955528)

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Ratio of titers to viral load at the time of peak viral load in cynomolgus macaques infected with Lassa (top) or Ebola (bottom) virus. by Guillaume Lingas (9955528)

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Evolution of target cells TC, productive infected cells I2, refractory cells R and immune effector F. by Guillaume Lingas (9955528)

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BIC of models tested throughout model building. by Guillaume Lingas (9955528)

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Mutagenesis model simulations. by Guillaume Lingas (9955528)

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Pharmacokinetic models and concentrations predictions of treatments considered. by Guillaume Lingas (9955528)

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Parameters distribution using model averaging (Median, 95% CI). by Guillaume Lingas (9955528)

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Individual fits of viral load (plain lines) and viral titers (dashed line) for best model considered (<i>κ</i> = 5). by Guillaume Lingas (9955528)

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Description of viral kinetics. by Guillaume Lingas (9955528)

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Post-mortem RNA viral load by organ. by Guillaume Lingas (9955528)

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Observed survival according to treatment received. by Guillaume Lingas (9955528)

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Predictions of titers/RNA at peak RNA viral load. by Guillaume Lingas (9955528)

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Parameters estimates distributions by model averaging. by Guillaume Lingas (9955528)

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Mutation of Ser-473 in GC-A to alanine but not glutamate decreases ANP-stimulated guanylyl cyclase activity. by Andrea R. Yoder (165684)