First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

First-in-Class Hydrazide-Based HDAC6 Selective Inhibitor with Potent Oral Anti-Inflammatory Activity by Attenuating NLRP3 Inflammasome Activation by Kairui Yue (11874403)

“…Low-dose <b>35m</b> remarkably decreases LPS-induced IL-1β release both <i>in vitro</i> and <i>in vivo</i> by blocking the activation of NLRP3, indicating that <b>35m</b> can be a potential orally active therapeutic agent for the treatment of NLRP3-related diseases.…”

Dynamics of a Stick−Jump Contact Line of Water Drops on a Strip Surface by Xueyun Zhang (507745)

“…In this study, we prepared microscale periodic rough structures consisting of parallel strips on a silicon surface. …”

DataSheet1_Solamargine Inhibits the Development of Hypopharyngeal Squamous Cell Carcinoma by Decreasing LncRNA HOXA11-As Expression.PDF by Ying Meng (327793)

Supplementary Material for: Inverse and Direct Cancer Comorbidity in People with Central Nervous System Disorders: A Meta-Analysis of Cancer Incidence in 577,013 Participants of 50... by Catalá-López F. (4142920)

“…<b><i>Method:</i></b> Comprehensive search in PubMed/MEDLINE, Scopus and ISI Web of Knowledge of the literature published before March 2013. We identified 51 relevant articles from 2,229 discrete references, 50 of which contained data suitable for quantitative synthesis (577,013 participants). …”

Multinomial logistic model of the effects of a cluster of phenolic compounds on host and parasitoid survival across development among larvae that survived to at least 50 mg. by Noah H. Rose (703745)

Strains carrying different <i>ELP3</i> mutant alleles show decreased telomeric gene silencing and increased HU sensitivity. by Changchun Chen (139128)

Leishmanization with <i>L</i>. <i>major</i> + Pam3CSK4 decreases lesion size and parasite burden in mice. by Lu Huang (211625)

Presentation_1_Airway macrophages display decreased expression of receptors mediating and regulating scavenging in early cystic fibrosis lung disease.pdf by Lisa J. M. Slimmen (16464600)

“…The effect of age and neutrophilic inflammation, among other variables, on marker expression was assessed with a multivariate linear regression model.</p>Results<p>AM expression of scavenger receptor CD163 decreased with age (p = 0.016) and was negatively correlated with BALF %neutrophils (r = -0.34, p = 0.016). …”

1466 slows the capsid assembly rate in biochemical Cp149 capsid assembly reactions. by Daniel P. Bradley (10306893)

Knockdown of Rab27a and disruption of microtubules decreased the number of granules docked at the PM. by Dongfang Liu (241581)

Compound 390 induces HBV capsid accumulation via an ROS-mediated mechanism. by Daniel P. Bradley (10306893)

Comparison of the decrease of CFU in CSF and blood between treatment groups within the first 6 h after treatment. by Luca G. Valente (12463057)

Decreased frequency of sEPSCs in <i>Dyt1</i> heterozygous KO mice. by Fumiaki Yokoi (170876)

Variation law of AE events rate of sandstone under different freeze-thaw cycles at a loading rate of 0.05 mm/min. by Wenyu Lv (20139458)

Variation law of AE events rate of sandstone under different freeze-thaw cycles at a loading rate of 0.05 mm/min. by Wenyu Lv (20139458)

Transient VEP loss due to manipulation of the optic nerve. by Yeda Luo (710942)

“…At 15:00, the VEP decrease reached the warning criterion (50%) and a warning was issued to the surgeon who consequently altered the surgical strategy. …”

<i>N</i>⁶-methyladenosine modification and the YTHDF2 reader protein play cell type specific roles in lytic viral gene expression during Kaposi's sarcoma-associated herp... by Charles R. Hesser (5147309)

“…In iSLK.219 cells the defect was linked to their roles in the post-transcriptional accumulation of the major viral lytic transactivator ORF50, which is m⁶A modified. In contrast, although the ORF50 mRNA was also m⁶A modified in KSHV infected B cells, ORF50 protein expression was instead increased upon depletion of METTL3, or, to a lesser extent, YTHDF2. …”

Correlation analysis between gene expression and DNA methylation for the CG (A), CHG (B), and CHH (C) contexts. by Lin Zhao (92451)

<em>RAD50</em> Is Required for Efficient Initiation of Resection and Recombinational Repair at Random, γ-Induced Double-Strand Break Ends by Jim Westmoreland (260234)

“…Unlike for enzymatically induced site-specific DSBs, little is known about processing of random “dirty-ended” DSBs created by DNA damaging agents such as ionizing radiation. Here we present a novel system for monitoring early events in the repair of random DSBs, based on our finding that single-strand tails generated by resection at the ends of large molecules in budding yeast decreases mobility during pulsed field gel electrophoresis (PFGE). …”