Schematic representation of the effects of stepwise bromination of the benzene ring of benzotriazole (Bt), including interdependence of the molecular volume (A) and pK_a (B) of the products with their IC₅₀ for inhibition of protein kinase CK2α: (a) Green arrows follow sequential bromination of the central vicinal C(5)/C(6) atoms, leading to a moderate decrease of pK_a and a large decrease in IC₅₀; (b) Red arrows illustrate the lesser effects of bromination of the peripheral C(4)/C(7) atoms, resulting in a significant decrease of pK_a, with virtually no gain in inhibitory activity; (c) Black lines link products with the same number of bromine atoms, but substantially differing in pK_a and IC₅₀, culminating in the di- and tri-brominated derivatives with inhibitory activities comparable to that of TBBt. by Romualda Wąsik (119538)

Effects of EtOH on spontaneous firing of cerebellar PCs. by Wataru Matsunaga (3452621)

Subjects:

FAST protein expression in A549 cells decreases cellular metabolic activity, promotes apoptosis and concomitant loss of membrane integrity. by Carmen M. Wong (3176730)

An Improved Genome Assembly of Azadirachta indica A. Juss. by Binay Panda (768771)

“…The updated genome assembly (v2.0) yielded 3- and 3.5-fold increase in N50 and N75, respectively; 2.6-fold decrease in the total number of scaffolds; 1.25-fold increase in the number of valid transcriptome alignments; 13.4-fold less mis-assembly and 1.85-fold increase in the percentage repeat, over the earlier assembly (v1.0). …”

Rap1A knockdown <i>in vitro</i> impairs steady state monolayer integrity and decreases transepithelial electrical resistance. by Erika S. Wittchen (256700)

Transaldolase deficiency causes a starvation-like response that decreases animal fat content and rewires lipid metabolism gene expression. by Christopher F. Bennett (3875731)

“…<p><b>(A)</b> Intestinal fat staining decreases from RNAi knockdown of <i>tald-1</i> or <i>cco-1</i>. …”

Data_Sheet_1_Temporary Salt Lakes: Ecosystem Services Shift in a Ramsar Site Over a 50-Year Period.DOCX by Ioanna Ioannidou (11034120)

Virucidal activity of LA, SCFA, and succinic acid combinations associated with an optimal vaginal microbiota or BV, representing a non-optimal vaginal microbiota. by Muriel Aldunate (22411177)

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Decreased echinocandin susceptibility in <i>Candida parapsilosis</i> causing candidemia and emergence of a pan-echinocandin resistant case in China by Yating Ning (11264310)

Percentage of rewarded USV from the total number of USV (AB) and the number of 50-kHz USV (CD) during training in rats with 7 (AC) or 14 training sessions (BD). by Agnieszka D. Wardak (17941139)

Effect of CM from osteoblasts cultured with CXCL8 (200 pg/ml) or CCL20 (500 pg/ml) on osteoclastic bone resorption. by Janak L. Pathak (759122)

Effect of CXCL8 (200 pg/ml), CCL20 (500 pg/ml), CXCL8-CM, and CCL20-CM on osteoclast formation. by Janak L. Pathak (759122)

LA is a more potent inhibitor of HIV-1 virion-associated RT activity compared to acetic acid or low pH (HCl) alone. by Muriel Aldunate (22411177)

Subjects:

Mean sum of squares for MI% and chromosomal aberrations from mung bean root tips under Cd alone and priming with phytohormones and proline before Cd stress. by Meher Hassan (11502144)

Subjects:

High glucose induces a mild decrease in KIF5B but does not affect the overall content and distribution of tau, KIF1A and dynein in hippocampal cultures. by Filipa I. Baptista (145150)

miR-155 suppresses atherosclerotic plaque progression, reduces macrophage accumulation, as well as decreases TNF-a and IL-6 levels in the thoracic aorta of ApoE^−/− mice.... by Jianhua Zhu (50548)

Data Sheet 1_Reduced hemolytic complement activity in the classical pathway (CH50) is a risk factor for poor clinical outcomes of patients with infections: a retrospective analysis... by Hiroyuki Koami (3878434)

“…</p>Results<p>Of 2,726 patients who met the inclusion criteria, logistic regression models demonstrated that decreased CH50 is a significant predictor of 180-day mortality (OR: 0.98-0.99). …”

Flowchart of patients. by Seydou Goro (17847203)

Effects of increasing temperature and, CO₂ on quality of litter, shredders, and microorganisms in Amazonian aquatic systems by Renato Tavares Martins (4634317)

“…We hypothesized that simulated climate change (warming and elevated CO₂) would: i) decrease leaf-litter quality, ii) decrease survival and leaf breakdown by shredders, and iii) increase microbial leaf breakdown and fungal biomass. …”

SDG decreases iron-induced MMP gene expression in H9c2 cells. by Stephanie Puukila (568109)