Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies by Fawaz E., Alanazi

“…Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …”
Get full text
Get full text
Get full text

Metformin attenuates V-domain Ig suppressor of T-cell activation through the aryl hydrocarbon receptor pathway in Melanoma: In Vivo and In Vitro Studies by Fawaz E., Alanazi

“…Here, metformin significantly decreased VISTA and AHR levels in vitro and in vivo. …”
Get full text
Get full text
Get full text

Understanding the False Positive of Modified Martensitic Steels in Sweet & Sour Service Conditions Using a Point Defect Model Perspective by Martinez, Alan

“…These results indicate a critical point in temperature in the tests with only CO2, where resistance to pitting susceptibility is maximized due to a decrease in the cation vacancy diffusivity.…”
Get full text

INTERACTION BETWEEN CLOCK GENE AND LIFESTYLE FACTOR IN RELATION TO OBESITY RISK FACTOR by ABDULKADER, HADIL

“…Women showed a strong association with obesity compared to men (OR: 1.51, 95% CL: 1.32-1.73), while smokers and ex-smokers had a decreased odds of having obesity by 21% and 12% respectively in comparison to nonsmokers. …”
Get full text

A robust experimental-based artificial neural network approach for photovoltaic maximum power point identification considering electrical, thermal and meteorological impact by Gowid, Samer

“…The results showed a decrease in the MSE of Vmp by 74.3% (from 1.6 V to 0.411 V), and in the MSE of Imp by 95% (from 4.4e−6 A to 2.16e−7 A), respectively. …”
Get full text
Get full text
Get full text

Identification of key genes regulating macronutrient accumulation and final yield in wheat under potassium deficiency by Thabet, Samar G.

“…Interestingly, the TraesCS1B02G359800 gene was located on chromosome 3B and annotated as protein kinases that harbor the variation of NGS, P, Mg_K2, and Mg_K1. …”
Get full text
Get full text
Get full text

Molecular properties prediction, anticancer and anti-inflammatory activities of some pyrimido[1,2-b]pyridazin-2-one derivatives by Zeiz, Ali

“…Compound 1 also induced a statistically significant decrease in the gene expression of various cytokines and chemokines. …”
Get full text
Get full text

STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS by AL-SADEQ, DUAA WALID

“…This reduced activity is consistent with both in vitro and in silico evidence, which indicates that the studied CBS mutations, except p.K72I, significantly decrease the overall protein's stability, which may represent the underlying cause of their pathogenicity. …”
Get full text

The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets by Cenciarelli, Carlo

“…In the current study, we assessed the effects of Hes1-targeted shRNA, a Notch1 gene target, specifically on GBM CSC refractory to GSI-X. …”
Get full text

Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria by Al-Sadeq, Duaa W.

“…Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). …”
Get full text
Get full text
Get full text

Green Revolution dwarfing Rht genes negatively affected wheat floral traits related to cross-pollination efficiency by Schierenbeck, Matías

“…Anthers extrusion decreased from 40% (rht) to 20% (Rht1 and Rht2), 11% (Rht3), 8.3% (Rht1 + 2), and 6.5% (Rht2 + 3). …”
Get full text
Get full text
Get full text

The Expression of TBC1 Domain Family, Member 4 (TBC1D4) in Skeletal Muscles of Insulin-Resistant Mice in Response to Sulforaphane by Rizk, Nasser M

“…TBC1D4 gene is involved in the trafficking of GLUT4 to the outer cell membrane in skeletal muscle. …”
Get full text
Get full text

Transcriptome assembly, profiling and differential gene expression analysis of the halophyte Suaeda fruticosa provides insights into salt tolerance by Diray-Arce, Joann

Get full text
Get full text

Cardiac Myosin Binding Protein-C in Sprague Dawley (SD) Rats exposed to Sub-Chronic oral dose of Cadmium Chloride by Al-Borshaid, Enjoud Khalifa

“…The data demonstrated that cadmium decreased cMyBP-C at the protein level and downregulated its expression at the gene level. …”
Get full text
Get full text

A Reverse MultipleChoice Based mLearning System by Karkar, AbdelGhani

Get full text
Get full text

Growth performance, intestinal histomorphology, gut microflora and ghrelin gene expression analysis of broiler by supplementing natural growth promoters: A nutrigenomics approach by Gilani, S.M.H.

“…Addition of phytobiotics significantly improved (p < 0.05) villus height and ratio of villus height/crypt depth in ileum, jejunum, and duodenum and down-regulated ghrelin gene expression levels. Total coliform and Escherichia coli in cecal and ileal digesta were decreased significantly (p < 0.05) in organic acids group. …”
Get full text
Get full text
Get full text

Effect of BPA on CYP450s expression, and nicotine modulation, in fetal rat brain by Mohammad H., Merii

“…Fetal brains were isolated at gestational days GD14 and GD19, and protein expression was assessed by Western blotting. Results showed a BPA-induced significant decrease in CYP1B1 expression levels at GD14 (p = 0.001), and CYP19A1 (aromatase) expression at both mid- and late-stage development (p < 0.001). …”
Get full text
Get full text
Get full text

Determining the role of missense mutations in the POU domain of HNF1A that reduce the DNA-binding affinity: A computational approach by P., Sneha

“…Maturity-onset diabetes of the young type 3 (MODY3) is a non-ketotic form of diabetes associated with poor insulin secretion. …”
Get full text
Get full text

The Cellular Interplay Between Na+/H+ Exchanger Isoform I and Osteopontin in Cardiac Hypertrophy by Abdelaziz, Iman Ahmed

“…Recently, Transgenic mice expressing active-NHE1 demonstrated a>1500-fold increase in osteopontin (OPN) gene expression. …”
Get full text

Comparing Methods for Induction of Insulin Resistance in Mouse 3T3-L1 Cells. by Al-Jaber, Hend

“…Hypoxia increased HIF1a gene expression by approximately 30% (P<0.01). …”
Get full text
Get full text