A computational approach for investigating the mutational landscape of RAC-alpha serine/threonine-protein kinase (AKT1) and screening inhibitors against the oncogenic E17K mutation... by Thirumal Kumar, D

“…The molecular interaction study also revealed that the co-crystallized AKT1 inhibitor N-(4-(5-(3-acetamidophenyl)-2-(2-aminopyridin-3-yl)-3H-imidazo [4,5-b]pyridin-3-yl)benzyl)-3-fluorobenzamide (12j) exhibited a better interaction with native AKT1 compared with the E17K mutant AKT1 protein, whereas, Akti-1/2 exhibited the opposite effects, i.e., a better interaction with the E17K mutant AKT1 than the native AKT1. …”
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Ecotoxicological Assessment of Thermally- and Hydrogen-Reduced Graphene Oxide/TiO₂ Photocatalytic Nanocomposites Using the Zebrafish Embryo Model. by Al-Kandari, Halema

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Computational approach to unravel the impact of missense mutations of proteins (D2HGDH and IDH2) causing D-2-hydroxyglutaric aciduria 2. by Thirumal Kumar, D

“…In the case of D2HGDH protein, the mutations I147S and V444A that are positioned in the beta sheet region exhibited higher Root Mean Square Deviation (RMSD), decrease in compactness and number of intramolecular hydrogen bonds compared to the mutations N439D and D375Y that are positioned in the turn and loop region, respectively. …”
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Structural analysis of missense mutations in galactokinase 1 (GALK1) leading to galactosemia type-2. by P, Sneha

“…Molecular docking analysis revealed a decrease in interaction between the protein and ATP in all the 3 mutations, and molecular dynamic simulations of 50 ns showed a loss of stability and compactness in the mutant proteins. …”
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Tailoring the deposition of MoSe2 on TiO2 nanorods arrays via radiofrequency magnetron sputtering for enhanced photoelectrochemical water splitting by Ahmad, Yahia H.

“…Compared to pure TiO2 NRs, the heterojunction nanostructured assembly displayed excellent spectral and photoelectrochemical properties, including more surface oxygen vacancies, enhanced visible-light absorption, higher photocurrent response, and decreased charge transfer resistance. In particular, the sample synthesized by sputtering of MoSe2 for 90 s, i.e., MoSe2@TiO2-90 s, depicted the highest current density (1.86 mA cm−2 at 0.5 V vs. …”
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Abnormal brain structure and behavior in MyD88-deficient mice. by Schroeder, Patricia

“…Because the adaptor protein myeloid differentiation primary response protein 88 (MyD88) is essential for downstream signaling of most TLRs and IL-1R, we systematically investigated the effect of MyD88 deficiency on murine brain structure during development and on behavior. …”
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Locations of Temporary Distribution Facilities for Emergency Response Planning by Pradhananga, Rojee

“…We assume that the individual demands in close vicinity are grouped at so-called aggregated demand points (ADPs). The distribution process initiates from a central supply point (CSP) which is a collection point that continuously acquires the resources and prepares them for distribution. …”
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25-Hydroxyvitamin D serum levels inversely correlate to disease severity and serum C-reactive protein levels in patients with hidradenitis suppurativa by Moltrasio, Chiara

“…Vitamin D exerts functions in skin physiology by modulating keratinocyte proliferation and different immunoregulatory processes.1 In several dermatoses, vitamin D correlates to disease severity and is significantly lower if compared to healthy subjects.2 Hidradenitis suppurativa (HS) is a chronic inflammatory disease characterized by painful suppurating lesions mainly localized in the folds.3 Kelly et al.4 conducted the first study assessing vitamin D status in HS, concluding that 75% of patients had vitamin D levels of less than 50 nmol/L compared to 40% of the general population. …”
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Impact of fines type on gas flow using 3D micro-computed tomography by Al-Raoush, Riyadh

“…The qualitative and quantitative findings achieved in this work in 3D, agree with other observations in recent literature on 2D micromodels. …”
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Impact of fines type on gas flow using 3D micro-computed tomography by Al-Raoush, Riyadh

“…The qualitative and quantitative findings achieved in this work in 3D, agree with other observations in recent literature on 2D micromodels. …”
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Chronic melatonin treatment improves obesity by inducing uncoupling of skeletal muscle SERCA-SLN mediated by CaMKII/AMPK/PGC1α pathway and mitochondrial biogenesis in female and ma... by Salagre, D.

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Vitamin D status affects proteomic profile of HDL-associated proteins and inflammatory mediators in dyslipidemia by Hanaa, Mousa

“…Our findings indicated a decrease in HDL-associated apolipoproteins (ApoM and ApoD) in individuals with both dyslipidemia and vitamin D deficiency. …”
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Association between Serum Vitamin D Status and Circadian Syndrome: A Cross-Sectional Study by Arabi, Ahmed

“…Results: Our results indicated that low vitamin D levels exhibited meaningful associations with CircS, with vitamin D deficiency and inadequacy demonstrating 2.21-fold (95% CI 1.78-2.74, p < 0.001) and 1.33-fold (95% CI 1.14-1.54, p < 0.001) increases in CircS odds, respectively. …”
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Nanotargeted Delivery of Immune Therapeutics in Type 1 Diabetes by Jung, Sungwook

“…Immune therapeutics holds great promise in the treatment of type 1 diabetes (T1D). Nonetheless, their progress is hampered by limited efficacy, equipoise, or issues of safety. …”
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Erratum: ITRAQ-based Quantitative Protein Expression Profiling and MRM Verification of Markers in Type 2 Diabetes (Journal of Proteome Research (2012) 11 (5527-5537) DOI: 10.1021/p... by Kaur, Prabhjit

“…As expected, the diabetic cohort showed an elevation in serum glucose, HbA1c, and insulin levels and a decrease in the serum levels of Vitamin D and HDL .Addition/Correctionpubs.acs.org/jpr © 2013 American Chemical Society 1065 dx.doi.org/10.1021/pr4000224 | J. …”
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Structural and magnetic properties of Ni1-xZnxFe 2O4 (x=0, 0.5 and 1) nanopowders prepared by sol-gel method by Gao P.

“…A series of nanostructured Ni-Zn ferrites Ni1-xZn xFe2O4 (x=0, 0.5 and 1) with a grain size from 24 to 65 nm have been prepared with a sol-gel method. …”
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A Reverse MultipleChoice Based mLearning System by Karkar, AbdelGhani

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Comparative Study on Gas-Sensing Properties of 2D (MoS2, WS2)/PANI Nanocomposites-Based Sensor by Parangusan, Hemalatha

“…Therefore, the composite PANI/2D-TMDs is a suitable material for NH3 gas detection applications.…”
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Advanced Hard Ctings: Towards A Whole New World by Santecchia, Eleonora

“…That is where advanced surface coatings come in. From a manufacturing point of view, tools for machining are of particular interest. …”
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Study of the Ion Interclation Mechanism in Mxene Membrane for the Water Treatment Applications by Helal, Mohamed Ibrahim Elsayed Ali Hussein

“…MXene membrane consists of free-standing layers of a 2D material, namely MXene, which is attracting growing interest due to its conductivity and well-defined interlayer distance and slit-like channels, making it attractive in applications like energy storage and water treatment applications. …”
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