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In vitro evaluation of Neosetophomone B inducing apoptosis in cutaneous T cell lymphoma by targeting the FOXM1 signaling pathway
Published 2023“…Moreover, NSP-B suppressed FOXM1-regulated genes, such as Aurora Kinases A and B, CDKs 4 and 6, and PLK1. …”
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PROFILE OF OXIDATIVE STRESS GENES IN RESPONSE TO OBESITY TREATMENT
Published 2021“…Conclusion: This study demonstrated that SFN had lowered body weight in WT-DIO mice by decreasing OS damage in skeletal muscles through the NrF2 pathway and can be a potential anti-obesity drug.…”
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24
Investigating the structural impacts of a novel missense variant identified with whole exome sequencing in an Egyptian patient with propionic acidemia
Published 2020“…Propionic Acidemia (PA) is an inborn error of metabolism caused by variants in the or genes, leading to mitochondrial accumulation of propionyl-CoA and its by-products. …”
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25
Investigation of flexible polymer-Tl2O3 nanocomposites for x-ray detector applications
Published 2019“…The membranes are utilized as conductometric X-ray sensors, and their response increases with increasing X-ray generator voltage. …”
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Corrosion inhibition of API X120 steel in a highly aggressive medium using stearamidopropyl dimethylamine
Published 2017“…The overall results showed that SAPDA significantly decreased the corrosion rate of API X120 steel with an inhibition efficiency of approximately 99% at an inhibitor concentration of 136 μmol L− 1. …”
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28
Novel potentials of the DPP-4 inhibitor sitagliptin against ischemia-reperfusion (I/R) injury in rat ex-vivo heart model
Published 2018“…Sitg oral treatment of different doses (25, 50, 100, and 150 mg/kg/day), or saline as a Control. …”
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Electrochemical and thermodynamic study on the corrosion performance of API X120 steel in 3.5% NaCl solution
Published 2020“…The overall results revealed that PEI significantly decreases the corrosion rate of API X120 steel with inhibition efficiency of 94% at a concentration of 100 μmol L−1. …”
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Growth performance, intestinal histomorphology, gut microflora and ghrelin gene expression analysis of broiler by supplementing natural growth promoters: A nutrigenomics approach
Published 2021“…Addition of phytobiotics significantly improved (p < 0.05) villus height and ratio of villus height/crypt depth in ileum, jejunum, and duodenum and down-regulated ghrelin gene expression levels. Total coliform and Escherichia coli in cecal and ileal digesta were decreased significantly (p < 0.05) in organic acids group. …”
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Effect of hypoxia on metabolic markers and gene expression HIF-1 α in adipocytes
Published 2015“…Results: Under hypoxia conditions, DHA treatment resulted in significant changes in all critical parameters of adipocyte biology including HIF-1α RNA expression (decreased by 50%), decreased lactate and glycerol release (66% and 25% respectively), and reactive oxygen species (ROS) production (decreased by 15%), while glucose uptake was decreased by 25% accompnied by decreased secretion of pro-inflammatory markers (Interleukin 6 IL-6, 31% reduction) , macrophage chemoattractant protein 1 MCP-1 (38% reduction) and leptin (14% reduction), and increased adiponectin secretion (by 45%). …”
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INTERACTION BETWEEN CLOCK GENE AND LIFESTYLE FACTOR IN RELATION TO OBESITY RISK FACTOR
Published 2024“…Circadian rhythms are maintained by a transcriptional auto-regulatory feedback loop including core clock genes. …”
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Corrosion behavior of API-X120 carbon steel alloy in a GTL F-T process water environment at low COD concentration
Published 2020“…The effect of temperature, time and rotation speed of FT-GTL process water on the corrosion rate of API X-120 carbon steel was investigated. Electrochemical impedance spectroscopy and potentiodynamic polarization techniques were used to determine the carbon steel corrosion rate under temperatures ranging from 293 to 323 K and rotation speed of 0, 500, 1000, 2000 rpm when the immersion time was 0.5, 1, and 2 h. …”
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Identification of key genes regulating macronutrient accumulation and final yield in wheat under potassium deficiency
Published 2024“…The wheat grains were analyzed for four macronutrients, mainly magnesium (Mg), calcium (Ca), potassium (K), and phosphorus (P), as well as yield attributes, under both treatments. A statistically significant decrease was observed for all assessed minerals and yield traits in wheat accessions under low potassium. …”
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The expression of bile acid Receptor TGR5 in Adipose Tissue in Diet-induced obesity mice
Published 2020“…There was significant downregulation of TGR5 gene expression level in obese (DIO) mice and remarkable upregulation of TGR5 gene expression after successful weight loss in DIO mice treated with SFN in time dependent manner at 1 weeks and 4 weeks of ip applications. In conclusion, obesity is associated with decrease in expression of TGR5 in different fat depots and treatment with anti-obesity drug (Sulforaphane) causes stepwise upregulation of TGR5 gene expression in epididymal white adipose tissue parallel stepwise decrease in body weight. …”
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STRUCTURAL AND FUNCTIONAL APPROACHES TOWARD ACTIVITY RESTORATION OF NOVEL CYSTATHIONINE BETA-SYNTHASE MUTATIONS
Published 2024“…Homocystinuria, a rare disorder stemming from mutations in the CBS gene, results in cystathionine β-synthase (CBS) deficiency. …”
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Biochemical and structural impact of two novel missense mutations in cystathionine β-synthase gene associated with homocystinuria
Published 2024“…Homocystinuria is a rare disease caused by mutations in the CBS gene that results in a deficiency of cystathionine β-synthase (CBS). …”
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The Interference of Notch1 target Hes1 affects cell growth, differentiation and invasiveness of glioblastoma stem cells through modulation of multiple oncogenic targets
Published 2017“…In the current study, we assessed the effects of Hes1-targeted shRNA, a Notch1 gene target, specifically on GBM CSC refractory to GSI-X. …”
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Transcriptome assembly, profiling and differential gene expression analysis of the halophyte Suaeda fruticosa provides insights into salt tolerance
Published 2015“…However, little is known about the genes involved in salt tolerance. We have characterized the transcriptome of Suaeda fruticosa, a halophyte that has the ability to sequester salts in its leaves. …”
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Green Revolution dwarfing Rht genes negatively affected wheat floral traits related to cross-pollination efficiency
Published 2024“…Hybrid breeding is a promising strategy to quickly improve wheat yield and stability. …”
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