Multiaction Platinum(IV) Prodrug Containing Thymidylate Synthase Inhibitor and Metabolic Modifier against Triple-Negative Breast Cancer by Nafees Muhammad (5641151)

“…As a result, <b>PFL</b> disrupts the mitochondrial ultrastructure and induces significant alterations in the mitochondrial membrane potential, which further leads to an increase in production of reactive oxygen species (ROS) and a decrease in ATP synthesis in MDA-MB-231 TNBCs. Western blot analysis reveals the formation of ternary complex of thymidylate synthase, which shows the intracellular conversion of tegafur into 5-FU after its release from <b>PFL</b>. …”

Logging intensity effects on genetic diversity, effective population size, spatial genetic structure and gene flow in Araucaria angustifolia (Araucariaceae) by Evandro Tambarussi (11751434)

“…After logging, Ne reduced from 28.8 (LI= 18.4%) to 30.5% (LI= 31.9%), and some alleles were lost. Under the conditions evaluated in this study, selective logging of <em>A.…”

Image_3_Deciphering the influence of dietary synbiotics in white shrimp gut and its effects in regulating immune signaling pathways.tif by Sofia Priyadarsani Das (17830028)

“…However, the effects of synbiotics on the white shrimp intestinal microbiota remain poorly understood. In the present study, we targeted the V3–V4 region of 16S rRNA genes to analyze the effects of synbiotics on white shrimp gut microbiota. …”

Table_1_A Mutation in VWA1, Encoding von Willebrand Factor A Domain-Containing Protein 1, Is Associated With Hemifacial Microsomia.DOCX by Yibei Wang (5321825)

“…</p>Methods<p>Whole exome sequencing (WES) was performed on five patients, one asymptomatic carrier, and two marry-in members of a five-generation pedigree. …”

Image_9_Integrated Isoform Sequencing and Dynamic Transcriptome Analysis Reveals Diverse Transcripts Responsible for Low Temperature Stress at Anther Meiosis Stage in Rice.PDF by Zhaojun Qu (9012878)

“…<p>Low temperatures stress is one of the important factors limiting rice yield, especially during rice anther development, and can cause pollen sterility and decrease grain yield. In our study, low-temperature stress decreased pollen viability and spikelet fertility by affecting the sugar, nitrogen and amino acid contents of anthers. …”

Table1_Exploratory study of autophagy inducer sirolimus for childhood cerebral adrenoleukodystrophy.docx by Xiao-Mei Luo (16030067)

“…After sirolimus treatment, three of the four patients with an initial NFS > 10 showed improvements in their clinical symptoms. Loes scores decreased by 0.5–1 point in two of eight patients and remained unchanged in one patient. …”

Table_2_Comparison Analysis of Different DNA Extraction Methods on Suitability for Long-Read Metagenomic Nanopore Sequencing.docx by Lei Zhang (38117)

“…Some emerging mNGS technologies with long-read ability are useful to decrease sequencing time and increase diagnosed accuracy, which is of great significance in rapid pathogen diagnosis. …”

Data_Sheet_1_Core Gut Bacteria Analysis of Healthy Mice.PDF by Jingjing Wang (140791)

“…Co-abundance analysis showed that these core genera were clustered into five groups (Group C1–C5), which were ecologically related. …”

Table_2_Genome-Wide Identification of Rare and Common Variants Driving Triglyceride Levels in a Nevada Population.XLSX by Robert W. Read (6248582)

“…The study identified 549 significant single-variant associations (p < 8.75 × 10^–9), many in chromosome 11’s triglyceride hotspot: ZPR1, BUD13, APOC3, APOA5. A well-known protective loss-of-function variant in APOC3 (R19X) was associated with a 51% decrease in triglyceride levels in the cohort. …”

Table_2_Deciphering the influence of dietary synbiotics in white shrimp gut and its effects in regulating immune signaling pathways.doc by Sofia Priyadarsani Das (17830028)

“…However, the effects of synbiotics on the white shrimp intestinal microbiota remain poorly understood. In the present study, we targeted the V3–V4 region of 16S rRNA genes to analyze the effects of synbiotics on white shrimp gut microbiota. …”

Table_4_Deciphering the influence of dietary synbiotics in white shrimp gut and its effects in regulating immune signaling pathways.doc by Sofia Priyadarsani Das (17830028)

“…However, the effects of synbiotics on the white shrimp intestinal microbiota remain poorly understood. In the present study, we targeted the V3–V4 region of 16S rRNA genes to analyze the effects of synbiotics on white shrimp gut microbiota. …”

Table_1_Blood cadmium level as a risk factor for chronic pain: NHANES database 1999–2004.DOCX by Panpan Mi (11574814)

“…Compared to the lower blood cadmium tertile 1 (<0.3 ug/dL), the adjusted odds ratios (ORs) for tertile 2 (0.3–0.4 ug/dL), and tertile 3 (≥0.5 ug/dL), were 1.11 (0.96–1.29) and 1.2 (1.03–1.39), respectively. …”

Dispatchable capacity optimization strategy for battery swapping and charging station aggregators to participate in grid operations by Mingze, Zhang

“…Also, the aggregator does not worsen the original power load while meeting the EV swapping demand and can decrease the daily load fluctuations by 0.65% and 12.89%, reduce the peak–valley difference by 5.81% and 7.80%, and increase the load rate by 3.67% and 4.08% in working and non-working day situations through providing the dynamic dispatchable capacity for the grid.…”
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Characterization of α-syn pores. by Felix Schmidt (312801)

“…<p><b>A</b>) Depending on clamped voltage, the number of steps increasing or decreasing pore conductance (“G-up” and “G-down” refer to the number of steps per recorded trace of 10s) differs (N = 18804 steps in 74 pore formations with 42 traces each). …”

Optimization of TEV protease cleavage conditions. by Yu-Fu Hung (513472)

“…The different “+” font sizes indicate the increasing amounts of TEV protease with fusion peptide to protease molar ratios of approximately 100, 50 and 10. The progress of the TEV digest is monitored by observing the decrease of the band of the dual tagged GST-GB1-NS4A(1–48) fusion protein and a parallel increase of the free GST-GB1 dual tag band (B, D).…”

Thermodynamic properties of non-azeotropic refrigerant heat pumps under full operating conditions with non-phase-change heat sinks and heat soucres by Hemin Hu (21488860)

“…Additionally, the maximum temperature observed in the two-stage compression configuration was significantly lower compared to the regenerative setup. A comprehensive thermodynamic assessment = across all operating conditions indicated that <i>COP</i> of all configurations decreases markedly as heat production diminishes below 50% of full load. …”

Image1_Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011.jpg by Tara Smith (2558311)

“…Non-compartmental analysis showed that following a single dose, PPI-1011 exhibited peak levels between 6 and 12 h but also a long half-life with mean t_1/2 of 40 h. …”

Table2_Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011.pdf by Tara Smith (2558311)

“…Non-compartmental analysis showed that following a single dose, PPI-1011 exhibited peak levels between 6 and 12 h but also a long half-life with mean t_1/2 of 40 h. …”

NLP-7 signaling regulates SNB-1::GFP abundance at HSN synapses. by Navonil Banerjee (3909580)

“…(B, C) Quantification of average SNB-1::GFP (B) or DsRed2 (C) intensity in synaptic region of the HSNs for the genotypes indicated. Bars represent mean ± SEM for each condition. See also <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006697#pgen.1006697.s005" target="_blank">S5</a> and <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1006697#pgen.1006697.s006" target="_blank">S6</a> Figs for additional quantification of SNB-1::GFP and the active zone marker GFP::SYD-2. …”

Table1_Pharmacokinetics, Mass Balance, Excretion, and Tissue Distribution of Plasmalogen Precursor PPI-1011.pdf by Tara Smith (2558311)

“…Non-compartmental analysis showed that following a single dose, PPI-1011 exhibited peak levels between 6 and 12 h but also a long half-life with mean t_1/2 of 40 h. …”