Image_4_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_1_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Image_2_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

The iron-overload induced ferroptosis of TgCtwh3-infected HT-22 cells <i>in vitro</i> could be inhibited by DFP. by Chong Wang (120449)

“…<p>(A) Western blot analysis of 4-HNE and COX2 expression in the HT-22 cells uninfected and infected with the TgCtwh3. …”

Image_3_Multi-omics analysis identifies IgG2b class-switching with ALCAM-CD6 co-stimulation in joint-draining lymph nodes during advanced inflammatory-erosive arthritis.tif by H. Mark Kenney (10320665)

“…Integration of single-cell and spatial transcriptomics revealed the increased IgG2b⁺ plasma cells localized in MARCO⁺ peri-follicular medullary sinuses. A concomitant decreased Fth1 expression (Early 2.5 ± 0.74 vs Advanced 1.0 ± 0.50 counts, p<0.001) within Advanced PLN sinuses was associated with accumulation of iron-laden Prussian blue positive macrophages in lymph nodes and synovium of Advanced TNF-Tg mice, and further validated in RA clinical samples. …”

Local Renyi entropic profiles of DNA sequences-6 by Susana Vinga (40513)

“…Each of the panels corresponds to a different sequence and position where the motif was correctly recovered just by using these maxima: a) m3, b) m4, c) m5 and d) Es (see also Table 1). The profiles for the and are also shown: apparently one can obtain a non-decreasing function of the positions, which means that previous suffixes are embedded in the implanted motifs.…”

GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells-7 by Raffaella Di Lisi (63653)

“…Each construct was tested in 4 to 5 independent experiments.…”

Beta cell-specific deletion of survivin. by Xiaohong Wu (147036)

“…(b) Western blots (left panel) and quantification (right panel) showing decreased expression of survivin in isolated islets from RIPcre⁺survivin^fl/fl mice in both sexes (n = 5 per genotype). …”

Pyruvate reduces R/M hypoglycemia-induced cortical blood vessel loss. by Bo Young Choi (301014)

“…(B) Graph represents the % area of RECA-1 immunoreactivity in the parietal and perirhinal cortex. Data are means ± s.e.m., n=5-6 from each group, *<i>P</i><0.05.…”

Insulin signalling canonical pathway. by Katarina Fredriksson (269501)

“…Gene descriptions can be found in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0003686#pone.0003686.s010" target="_blank">supplemental data sheet S5</a>. Red (and pink) means significantly increased gene expression and blue decreased. …”

GATA elements control repression of cardiac troponin I promoter activity in skeletal muscle cells-1 by Raffaella Di Lisi (63653)

“…Each construct was tested in 4 to 5 independent experiments.…”

Dynamo driven by precession in a spherical shell by Nathanael Schaeffer (474534)

“…<br>This means that for geophysical parameters (E<1e-10, Pm<1e-5) dynamo action in a spherical shell is very unlikely.…”

MiR-29b-2-5p, through repression of UNC5C expression, increases filopodia formation and <i>Shigella</i> capture by host cells. by Ushasree Sunkavalli (3916721)

“…Internalization and replication of <i>Shigella</i> within host cells lead to decreased levels of miR-29b-2-5p, which contributes to a balanced intracellular replication, avoiding premature cell death and favoring the efficient dissemination of <i>Shigella</i> to neighboring cells.…”

Sustained activation of β-catenin in the somatic cells leads to the induction of p53-mediated senescence in <i>Amhr2-Cre;Ctnnb1^Δ(ex3)/+</i> ovaries. by Pradeep S. Tanwar (143924)

“…Analyses also showed increased expression of pAKT and pS6K, and decreased expression of p21 and p27kip1 in <i>Amhr2-Cre;Ctnnb1^Δ(ex3)/+;Pten^Δ/Δ</i> ovaries. β-actin was used as a loading control. …”

Optical Activity and Dehydration-Driven Switching of Magnetic Properties in Enantiopure Cyanido-Bridged Co^II₃W^V₂ Trigonal Bipyramids by Szymon Chorazy (1396666)

“…The reversible removal of weakly bonded H₂O above 50 °C induces the structural phase transition <b>1</b> ⇄ <b>1deh</b> and strongly affects the magnetic characteristics. …”

Optical Activity and Dehydration-Driven Switching of Magnetic Properties in Enantiopure Cyanido-Bridged Co^II₃W^V₂ Trigonal Bipyramids by Szymon Chorazy (1396666)

“…The reversible removal of weakly bonded H₂O above 50 °C induces the structural phase transition <b>1</b> ⇄ <b>1deh</b> and strongly affects the magnetic characteristics. …”

Single-center retrospective study of the effectiveness and toxicity of the oral iron chelating drugs deferiprone and deferasirox by Nancy F. Olivieri (6407168)

“…The primary endpoint of monitoring in iron overload, hepatic iron concentration (HIC), increased (worsened) during deferiprone monotherapy (mean 10±2–18±2 mg/g; p < 0.0003), exceeding the threshold for life-threatening complications (15 mg iron/g liver) in 50% patients. During deferasirox monotherapy, mean HIC decreased (improved) (11±1–6±1 mg/g; p < 0.0001). …”

Data_Sheet_1_Early Changes in B and Plasma Cell Subsets and Traditional Serological Markers as Predictors of SRI-4 Response to Therapy in Systemic Lupus Erythematosus.docx by Ioannis Parodis (2851211)

“…</p>Results<p>In the analysis of the entire cohort, SRI-4 responders showed more prominent decreases from baseline through week 52 in CD19⁺CD20⁺CD27^– naïve B cells (median change: −61.2% versus −50.0%; P = 0.004), CD19⁺CD20^–CD27^bright plasmablasts (−44.9% versus −33.3%; P = 0.011), and CD19⁺CD20^–CD138⁺ long-lived plasma cells (−48.2% versus −37.1%; P = 0.024), and a more prominent rapid (+92.0% versus +66.7%; P = 0.002) and early (+60.0% versus +49.5%; P = 0.033) expansion of CD19⁺CD20⁺CD27⁺ memory B cells than non-responders. …”

Bacterial strains used in this study. by Nobuo Fuke (22190368)

“…We cultured <i><i>Escherichia coli</i></i> OP50 (the standard <i><i>C</i></i>. <i><i>elegans</i></i> food), <i><i>Prevotella</i></i> (<i><i>P</i></i>.) …”

DataSheet1_Decadal variability of precipitation over the Tibetan Plateau modulated by the 11-year solar cycle over the past millennium.docx by Ying Hu (14950)

“…Using an ensemble mean of four solar-only sensitivity experiments from the Community Earth System Model Last Millennium Ensemble (CESM‒LME), we further demonstrated that the 11-year solar cycle can induce this anomalous pattern of a wet central‒southern and dry southeastern Tibetan Plateau.…”