DataSheet_3_Natal environmental conditions modulate senescence of antler length in roe deer.csv by Solène Cambreling (16493826)

“…We found evidence of similar patterns of antler length senescence in both populations, with an onset of senescence around 7 years of age and a decrease of length by about 1–1.5 cm per additional year of life from 7 years of age onwards. …”

Video_1_Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway.mp4 by Yiwen Jiang (6697760)

“…<p>Chronic stress is suspected to be a causal factor of female subfertility; however, the underlying mechanisms remain unclear. Here, we found that chronic stress inhibited the cyclic adenosine 3′,5′-monophosphate (cAMP) signaling pathway, leading to ovarian reserve decline in mice. …”

Video_2_Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway.mp4 by Yiwen Jiang (6697760)

“…<p>Chronic stress is suspected to be a causal factor of female subfertility; however, the underlying mechanisms remain unclear. Here, we found that chronic stress inhibited the cyclic adenosine 3′,5′-monophosphate (cAMP) signaling pathway, leading to ovarian reserve decline in mice. …”

Data_Sheet_1_Modeling the positive testing rate of COVID-19 in South Africa using a semi-parametric smoother for binomial data.pdf by Olajumoke Evangelina Owokotomo (14661887)

“…Using publicly available data collected between March 5th, 2020 and May 31st, 2021, we proposed to estimate both the positive testing rate and its daily rate of change in South Africa with a flexible semi-parametric smoothing model for discrete data. …”

Supercooled Water Drops Impacting Superhydrophobic Textures by Tanmoy Maitra (1606972)

“…To this end, we describe an unobserved mechanism for superhydrophobicity breakdown: unlike for room temperature drops, where transition from bouncing to sticky (impaled) behavior occurs sharply at the condition of full texture penetration, with a bubble captured at the point of impact, under supercooled conditions, the full penetration velocity threshold is increased markedly (increasing by ∼25%, from 2.8 to 3.5 m/s) and no bubble is entrapped. …”

Changes in intestinal bacteria and imbalances of metabolites induced in the intestines of pancreatic ductal adenocarcinoma patients in a Japanese population: a preliminary result by Senju Hashimoto (13505458)

“…The purpose of this study was to elucidate the characteristics of the intestinal environment in PDAC.</p> <p>We performed a case-control study of 5 Japanese patients with unresectable PDAC located in the body or tail (PDAC-bt). …”

Image_6_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Autophagy pathway induced by a plant virus facilitates viral spread and transmission by its insect vector by Yong Chen (109188)

“…Applying the autophagy inhibitor 3-methyladenine or silencing the expression of <i>Atg5</i> significantly decrease viral spread <i>in vitro</i> and <i>in vivo</i>, whereas applying the autophagy inducer rapamycin or silencing the expression of <i>Torc1</i> facilitate such viral spread. …”

Protein Biomarkers and Risk Scores in Pulmonary Arterial Hypertension Associated with Ventricular Septal Defect: Integration of Multi-Omics and Validation by Chao Yuan (408257)

“…Proteomics (iTRAQ) identified 107 differential proteins (DPs) between patients with/without PAH including significantly increased ADIPO, DBH, ANPEP, TRF1, GP1BA and decreased GNAS in VSD-PAH. Metabolomics discovered 191 differential metabolites between patients with/without PAH including elevation of 5-HT, taurine, creatine, sarcosine, and 2-oxobutanoate and decrease of vanillylmandelic acid, 3,4-dihydroxymandelate, 15-Keto-PGF2, fructose-6-phosphate , L-glutamine, dehydroascorbate, hydroxypyruvate, threonine, L-cystine, and 1-aminocyclopropane-1-carboxylate. …”

Image_10_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

The Effect of Rosuvastatin in a Murine Model of Influenza A Infection by Kathryn A. Radigan (169555)

“…<div><h3>Rationale</h3><p>HMG-CoA reductase inhibitors such as rosuvastatin may have immunomodulatory and anti-inflammatory effects that may reduce the severity of influenza A infection. We hypothesized that rosuvastatin would decrease viral replication, attenuate lung injury, and improve mortality following influenza A infection in mice.…”

Receptor for Advanced Glycation End-Products Signaling Interferes with the Vascular Smooth Muscle Cell Contractile Phenotype and Function by Elie Simard (481523)

“…We demonstrated that RAGE is expressed and functional in the A7r5 VSMC model, and its activation by AGE significantly increased NF-κB activity, which is known to interfere with the contractile phenotype of VSMC. …”

DataSheet_1_Chronic stress induces meiotic arrest failure and ovarian reserve decline via the cAMP signaling pathway.docx by Yiwen Jiang (6697760)

“…<p>Chronic stress is suspected to be a causal factor of female subfertility; however, the underlying mechanisms remain unclear. Here, we found that chronic stress inhibited the cyclic adenosine 3′,5′-monophosphate (cAMP) signaling pathway, leading to ovarian reserve decline in mice. …”

Data_Sheet_1_Network Modeling of Liver Metabolism to Predict Plasma Metabolite Changes During Short-Term Fasting in the Laboratory Rat.ZIP by Kalyan C. Vinnakota (43374)

“…We then measured plasma metabolite profiles in rats fasted for 5–7 or 10–13 h to test our model predictions. …”

Image_1_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Data Sheet 4_Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study.csv by Po-Chun Liu (676035)

“…Additionally, we identified an increase in the ARGORNPROST-PWY pathway (L-arginine degradation, q = 0.003) and a decrease in the PWY-6478 pathway (GDP-D-glycero-α-D-manno-heptose biosynthesis, q = 0.015) in MSA patients compared with HCs.…”

Nest design as an adaptative tool to escape brood parasitism by Angela Moreras (12024272)

“…Redstarts, on the other hand, reduced successful brood parasitism by placing nest cups further from the cavity entrance, but also selecting cavities with relatively smaller entrances. </p> <p>5. We show the importance of host nest design influencing the coevolution between hosts and brood parasites. …”

Image_9_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Image_7_Integrated single-cell transcriptome analysis of the tumor ecosystems underlying cervical cancer metastasis.jpeg by Chunbo Li (167815)

“…Finally, we demonstrated that cancer-associated fibroblasts (CAFs) in P-LN were associated with immune regulation, while CAFs in tumor underwent EMT. …”

Data Sheet 1_Altered gut microbial networks and metabolic pathways in multiple system atrophy: a comparative 16S rRNA study.pdf by Po-Chun Liu (676035)

“…Additionally, we identified an increase in the ARGORNPROST-PWY pathway (L-arginine degradation, q = 0.003) and a decrease in the PWY-6478 pathway (GDP-D-glycero-α-D-manno-heptose biosynthesis, q = 0.015) in MSA patients compared with HCs.…”