Sholl analysis and spine density analysis in mouse hippocampal neurons. by Qiang-qiang Xia (8060987)

“…D) Sholl analysis of WT and <i>Cul3</i> HET knockouts demonstrates decreased dendritic branching in <i>Cul3</i> HET mutant neurons, a main effect of genotype was observed (P = 0.002, WT N = 30/10 cells/mice; HET N = 30/10). …”

OLC15, MIA, and HMA affect different targets of the pheromone transduction cascade. by Andreas Nolte (409768)

“…<p>(A) The bombykal (50 ms; 1 μg on filter paper)—dependent AP response consists of at least 3 phases which occur at characteristic time windows after the pheromone stimulus (red arrow), also at other pheromone doses employed. …”

Dual transfection of <i>gp70</i> and <i>Mcm2</i> enhances DNA-damage-induced apoptosis in 3T3 cells. by Shinya Abe (154673)

“…Cell survival is significantly different between control cells “<i>gp70</i> (−), <i>Mcm2</i> (−)” and <i>gp70/Mcm2</i>-transfected cells “<i>gp70</i> (+), <i>Mcm2</i> (+)” (#<i>p</i><0.01). Data represent the mean and 95% CI of 3 independent experiments. (<b>C</b>) Apoptotic cell ratios in <i>gp70</i> and/or <i>Mcm2</i>-transfected 3T3 cells were determined with annexin V-staining after treatment with 1 µM doxorubicin for 24 h. …”

Impact of different clear corneal incision sizes on anterior corneal aberration for cataract surgery by Qing-Qing Tan (8066828)

“…Only patients with preexisting anterior corneal astigmatism <2.00 diopters (D) and ≥0.50 D who underwent a steep meridian clear corneal incision were included. …”

Regulatory loop of high affinity iron uptake and cytosolic iron homeostasis based on an iron-dependent IRT1 degradation. by Oleg Agafonov (631744)

“…<p>(a) Scheme of the control loop. Fe_ext and Fe_cyt denote external and cytosolic iron, respectively. …”

Image 2_MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-li... by Eszter Vámos (11081587)

“…Leukocyte recruitment, M1 macrophage polarization and associated metabolic reprogramming are hallmarks of its pathomechanism. Here, we tested TE-11, a potent MIF tautomerase inhibitor (IC₅₀ = 5.63 μmol/dm³) in experimental Crohn’s disease in male mice, in leukocyte recruitment and in inflammatory M1 macrophage activation.…”

Image 1_MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-li... by Eszter Vámos (11081587)

“…Leukocyte recruitment, M1 macrophage polarization and associated metabolic reprogramming are hallmarks of its pathomechanism. Here, we tested TE-11, a potent MIF tautomerase inhibitor (IC₅₀ = 5.63 μmol/dm³) in experimental Crohn’s disease in male mice, in leukocyte recruitment and in inflammatory M1 macrophage activation.…”

Image 4_MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-li... by Eszter Vámos (11081587)

“…Leukocyte recruitment, M1 macrophage polarization and associated metabolic reprogramming are hallmarks of its pathomechanism. Here, we tested TE-11, a potent MIF tautomerase inhibitor (IC₅₀ = 5.63 μmol/dm³) in experimental Crohn’s disease in male mice, in leukocyte recruitment and in inflammatory M1 macrophage activation.…”

Image 3_MIF tautomerase inhibitor TE-11 prevents inflammatory macrophage activation and glycolytic reprogramming while reducing leukocyte migration and improving Crohn’s disease-li... by Eszter Vámos (11081587)

“…Leukocyte recruitment, M1 macrophage polarization and associated metabolic reprogramming are hallmarks of its pathomechanism. Here, we tested TE-11, a potent MIF tautomerase inhibitor (IC₅₀ = 5.63 μmol/dm³) in experimental Crohn’s disease in male mice, in leukocyte recruitment and in inflammatory M1 macrophage activation.…”

Corticolous lichen community in an urbanization gradient in the Rio dos Sinos Hydrographic Basin, southern Brazil by Fabiane Lucheta (5160299)

“…A total of 215 lichen species were identified, of which nine species are new records: four are being cited for Brazil for the first time, and five for Rio Grande do Sul. As urbanization increased, a simplification of the lichen community structure was observed, as well as a decrease in species richness and changes on species composition. …”

<b>Dataset: Global dominance of lianas over trees is driven by forest disturbance, climate, and topography</b> by Alain Senghor K. Ngute (17352283)

Site-Directed Mutations and the Polymorphic Variant Ala160Thr in the Human Thromboxane Receptor Uncover a Structural Role for Transmembrane Helix 4 by Raja Chakraborty (187863)

“…Thermal activity assays showed decrease in receptor stability in the order, wild type>A160S>A160V>A160T>G164A, with G164A being the least stable. …”

The impact of refractive error correction on health-related quality of life in nursing home residents in Armenia by Aida Giloyan (16826909)

“…</p> <p>The mean age of participants was 72.6. About 42.0% had mild to severe visual impairment (VI), while 5.0% were blind. …”

Loss of BIG1 causes accumulation of excitatory neurons before destination layers. by Jia-Jie Teoh (3929852)

“…<p>(A) The layering order of UL neurons (Cux1⁺) and DL neurons (Tbr1⁺) was maintained in <i>Arfgef1</i>^{<i>geo/geo</i>} but the IZ thickness reduced at E17.5. Scale bars, 200 μm. n = 3 per group. (B) At E17.5, the numbers of Tbr1⁺, Cux1⁺ and DAPI⁺ cells within a 200 μm cortical width starting from the edge of the lateral ventricle were counted. …”

Table_1_Essential oils for treating anxiety: a systematic review of randomized controlled trials and network meta-analysis.doc by Ling Tan (167819)

“…Additionally, EOs could decrease systolic blood pressure (SBP) [WMD = −6.83, (95% CI −10.53, −3.12), P < 0.001] and heart rate (HR) [WMD = −3.43, (95% CI −5.51, −1.36), P < 0.001]. …”

DataSheet_1_Unveiling drug-tolerant and persister-like cells in Leishmania braziliensis lines derived from patients with cutaneous leishmaniasis.docx by Marlene Jara (774474)

“…</p>Results and discussion<p>We demonstrated in vitro that a variable proportion of cells remained viable, showing all the criteria of DT and not of DR: i) signatures of quiescence, under drug pressure: reduced proliferation and significant decrease of rDNA transcription; ii) reversibility of the phenotype: return to low IC₅₀ after removal of drug pressure; and iii) absence of significant genetic differences between exposed and unexposed lineages of each strain and absence of reported markers of DR. …”

Igf signaling is required for contribution of<i>gata4:EGFP</i> positive cardiomyocytes to the regenerating area. by Ying Huang (53474)

“…(I) Quantification of BrdU and <i>gata4:EGFP</i> double positive cells/<i>gata4:EGFP</i> area ± S.E. A significant decrease (*<i>p</i><0.05) in <i>gata4:EGFP</i> positive cell proliferation was detected in fish treated with Igf1r inhibitor NVP-AEW541 from 7–10dpa.…”

Supplementary Material for: Determination of the Endocannabinoids Anandamide and 2-Arachidonoyl Glycerol with Gas Chromatography-Mass Spectrometry: Analytical and Preanalytical Cha... by Lanz C. (5214566)

“…<b><i>Results:</i></b> In contrast to 2-AG, AEA was unstable in whole blood and increased by a factor of 2.3 within 3 h on ice. AEA was stable in plasma on ice for 4 h while 2-AG tended to decrease. …”

Genomic Analysis of Detoxification Supergene Families in the Mosquito <i>Anopheles sinensis</i> by Dan Zhou (29408)

“…<i>gambiae</i>, but represented a decrease of 29% and 42% compared with <i>Aedes aegypti</i> and <i>Culex quinquefasciatus</i>, respectively. …”

DataSheet1.pdf by Alexandre Lewalle (4876933)

“…Applying our framework, we identified the left-ventricular wall thickness (concentric hypertrophy) and the intracellular calcium dynamics as playing the dominant roles in preserving EF acutely, whereas the significance of hypertrophy decreased subsequently. This trend suggests an increasing reliance on intracellular mechanisms (average increase ~50%), rather than on anatomical features (average decrease ~60%), to achieve compensation of pump function in the early phase of heart failure.…”