Netrin-1 overexpression increases HCV RNA and specific infectivity of HCV virions in vitro whereas Netrin-1 depletion decreases HCV RNA and specific infectivity in vitro. by Marie-Laure Plissonnier (337713)

“…<b>L</b>. Netrin-1 depletion decreases specific infectivity of virions. Specific infectivity was calculated for each collected fraction using the TCID₅₀/HCV RNA ratio. …”

LuxR G37V has decreased DNA-binding activity. by Chelsea A. Simpson (9579303)

Figure S1 - TGF-β1 Downregulates COX-2 Expression Leading to Decrease of PGE2 Production in Human Lung Cancer A549 Cells, Which Is Involved in Fibrotic Response to TGF-β1 by Erina Takai (465811)

The number of strong contact and strong contact force of CFRP confined concrete specimens under three coal gangue replacement rates (0%, 50%, 100%). by Qingwen Li (1510687)

The number of strong contact and strong contact force of GFRP confined concrete specimens under three coal gangue replacement rates (0%, 50%, 100%). by Qingwen Li (1510687)

The number of strong contact and strong contact force of BFRP confined concrete specimens under three coal gangue replacement rates (0%, 50%, 100%). by Qingwen Li (1510687)

Eliminations of dorsal projections in DOM and DOM-A downregulation were due to reduced number of sLNvs and decrease of PDF. by Zhenxing Liu (399809)

Simulating within-vector generation of the malaria parasite diversity by Lauren M. Childs (593877)

“…However, diversity increases with the possibility for recombination and proliferation in the formation of sporozoites. Furthermore, when we begin with two parasite subpopulations in the initial gametocyte population, the probability of transmitting more than two unique parasites from mosquito to human is over 50% for a wide range of initial gametocyte densities.…”

(A) Spike patterns of 50 granule cells (GR; top) and Golgi cells (GO; bottom) by Tadashi Yamazaki (40072)

Competitive binding experiment. by Deepu Dowarha (5673440)

Localization of key HH signaling proteins is impaired in <i>Ttbk2</i>^{<i>sca11/gt</i>} cilia. by Emily Bowie (543704)

Identification of +TIPs required for MT plus-end targeting of dynein-dynactin in the <i>C</i>. <i>elegans</i> early embryo. by Daniel J. Barbosa (4288462)

“…Image corresponds to a maximum intensity projection over time (10 frames acquired every 200 ms). …”

Simulations that now also include a <i>symmetric</i> indoors/outdoors model, with a threshold temperature of 17.5C both in spring and in fall. by Sebastian A. Müller (10688740)

Example of a dependent variable. by Shinya Fukui (19259648)

HBV replication cycle with modeled activity of 1466, a bimodal HBV RNaseH-CAM-I Inhibitor, and other small molecule inhibitors used in this study. by Daniel P. Bradley (10306893)

BET Bromodomain Proteins Brd2, Brd3 and Brd4 Selectively Regulate Metabolic Pathways in the Pancreatic β-Cell by Jude T. Deeney (335344)

“…JQ1 (50–400 nM) increases insulin secretion from INS-1 cells in a concentration dependent manner. …”

Engineering of p150^DNC-1 mutants for functional characterization of dynactin's MT binding activity. by Daniel J. Barbosa (4288462)

“…Images correspond to maximum intensity projections over time (10 frames acquired every 200 ms). Scale bar, 5 μm. <b>(I)</b> Cortical confocal section of embryos as in <i>(H)</i>, additionally expressing EBP-2::mKate2 as a marker for MT plus ends. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”

Exploiting the 2‑Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery by Pasquale Linciano (4426435)

“…In particular, compound <b>4m</b>, a biphenyl-thiadiazole-2,5-diamine with IC₅₀ = 16 μM, was able to potentiate the antitrypanosomal activity of the dihydrofolate reductase inhibitor methotrexate (MTX) with a 4.1-fold decrease of the EC₅₀ value. …”