Table 1_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Image 6_PD-1/PD-L1 inhibitors plus bevacizumab plus chemotherapy versus PD-1/PD-L1 inhibitors plus chemotherapy for advanced non-small cell lung cancer: a phase 3 RCT based meta-an... by Chao Song (379006)

“…</p>Results<p>Three RCTs (IMpower150, jRCT2080224500, and ORIENT-31) comprising a total of 1529 patients were analyzed. The PIBC regimen significantly improved PFS (hazard ratio [HR]: 0.76 [0.66, 0.87], P < 0.0001), objective response rate (risk ratio [RR]: 1.36 [1.22, 1.51], P < 0.00001), and disease control rate (RR: 1.06 [1.00, 1.12], P = 0.04). …”

Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Global incidence, prevalence, years lived with disability (YLDs), disability-adjusted life-years (DALYs), and healthy life expectancy (HALE) for 371 diseases and injuries in 204 co... by Alize J, Ferrari

“…Non-communicable diseases contributed 1·73 billion (95% UI 1·54–1·94) DALYs in 2021, with a decrease in age-standardised DALY rates since 2010 of 6·4% (95% UI 3·5–9·5). …”
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Expression of <i>PAX</i> genes and MRFs during G₀ entrance (SM), exit (GM) and differentiation (DM). (A) <i>PAX3</i> and <i>PAX7</i> expression levels were high in G<sub... by Jeeva Sellathurai (399773)

“…After 6 h in SM only 2.5% (±1.1 SEM) of the cells were MYOGENIN positive and the fraction decreased further during culture in SM with a tendency for an increase up to 2.8% (±2.0 SEM). …”

Synthesis and Decomposition of Alkyl Complexes of Molybdenum(IV) That Contain a [(Me₃SiNCH₂CH₂)₃N]^3- Ligand. Direct Detection... by Richard R. Schrock (1295601)

“…Below ∼50 K the effective moments undergo a sharp decrease as a consequence of what are proposed to be a combination of spin−orbit coupling and zero field splitting effects. …”

Annual fluxes (kg N ha⁻¹ yr⁻¹) as total dissolved nitrogen, N-NH₄⁺, N-NO₃⁻ and dissolved organic nitrogen and effe... by Li-hua Tu (469843)

“…A positive value indicates the effect is increased, and a negative value indicates the decreased effect.…”

<b>Role of the Chaperone ClpB in</b><b> </b><b>Mycoplasma bovis</b><b> Virulence: Implications for </b><b>stress response, a</b><b>dhesion, </b><b>b</b><b>iofilm </b><b>d</b><b>eve... by Hui zhang (22187170)

“…<p dir="ltr">ClpB, an ATP-dependent molecular chaperone belonging to the Hsp100/Clp subfamily of AAA+ ATPases, plays a crucial role in protein disaggregation, thereby enhancing bacterial survival under stress conditions. …”

Propagation of the DMI signal into flanking regions in simulated data (sampled at generation 30, significance threshold: <i>X</i>(2)<−0.005 & <i>D’</i><0) when only homozygous geno... by Juan Li (146180)

“…To resemble the demography of the studied hybrid swordtail fish populations, the admixture proportion was set to <i>f</i> = 0.3 and the migration rate was <i>m</i> = 0.01. 200 individuals were sampled from each simulation to obtain the statistics. A. The number of significant marker pairs decreases rapidly with distance to the nearest true DMI locus. …”

Synaptic efficacy is reduced during UP states. by Brendon O. Watson (268774)

“…All measures were relative to a baseline defined by the mean membrane potential for 100 ms before stimulation. …”

Dopamine depletion increases intrinsic excitability of medium spiny neurons. by Karima Azdad (370732)

“…(D) Summary histogram of the mean first spike latency at the 120 pA current pulse illustrating the decrease of the first spike latency induced by dopamine depletion. …”

Exemplar press-related channel. by David T. Bundy (7586414)

“…Mean firing rates show a complex task response with firing rates significantly (p<0.05) decreased around the lever press and 650 ms prior to the reach to the pellet and then significantly increased immediately prior to the reach to the pellet. …”

Comparison between α1β2γ2 and α3β2γ2 GABA-channel currents elicited by brief GABA applications by Andrea Barberis (74413)

“…Journal Compilation © Federation of European Neuroscience Societies and Blackwell Publishing Ltd</p> (A) Multiple records of 1 s illustrating channel activity evoked by 2 ms applications of GABA to outside-out patches in two patches excised from human embryonic kidney (HEK) cells expressing single α1β2γ2 (left, 10 m GABA) and α3β2γ2 (right, 50 m GABA) channels (holding potential, −100 mV). …”

Transitions from Bursting to Single Spiking Output Are Mediated by Slow Recovery from Na⁺ Current Inactivation by Donald C Cooper (71501)

“…The inset shows a cumulative decrease in the action potential rise rate <i>(dV/dt)</i> (τ_1Hz = 17,980 ms, τ_2Hz = 925 ms, τ_10Hz = 250 ms; <i>n</i> = 14).…”

The effect on gliding responses of adding wings to looming discs with varying <i>l/|v|</i>. by Roger D. Santer (117354)

“…<p>A, Adding wings to looming discs caused a small, non-significant decrease in the relative frequency of glide occurrence across <i>l/|v|</i> values (see text). …”

The effect of coding time window on metabolically efficient information transmission. by Tomas Barta (8067509)

“…(E) Metabolic efficiency in bits per spikes. The decrease with the length of the coding time window shows us, that the adaptation effects visible in B don’t play a significant role in this case. …”

Pharmacological suppression of local activity abolishes non-linear interactions. by Michael T. Lippert (410615)

“…<p>A: General decrease in average rectified current source density (AVREC) caused by muscimol application (100 ms post-stimulus window, mean of both unisensory stimuli, n = 5, <i>P</i><0.05, U test). …”

Burst stimulation. by Damian M. Herz (16007088)

“…In all patients, DBS was given in bursts of varying duration (mean 250 ms). Between stimulation bursts was an approximately 500-ms long pause (mean 150 ms interval + ramping up and down each lasting ca. 175 ms on average = 500 ms, see also <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.3002140#pbio.3002140.s008" target="_blank">S1 Table</a>). …”

<i>In vitro</i> T2* measurement of macrophages labeled with iron oxide. by Hye Rim Cho (188703)

“…The T2* of the FION-labeled macrophages was decreased when the incubation concentration reached 50 µg Fe/mL (9.09±6.02 ms), however, the T2* of the macrophages labeled with 100 (µg Fe/mL) Feridex (62.50±7.69 ms) was higher than that of the macrophages labeled 12.5 µg Fe/mL FIONs (33.33±6.02 ms).…”

Inhibition controls levels of pattern separation in granule cells through different neural codes. by Antoine D. Madar (6619286)

“…<p><b>(A)</b> Single GCs were recorded twice in response to the same input set (P10Hz, R = 0.76 at τ_w = 10 ms, shown in <a href="http://www.ploscompbiol.org/article/info:doi/10.1371/journal.pcbi.1006932#pcbi.1006932.g001" target="_blank">Fig 1B</a>): First in normal aCSF, then under conditions of partial inhibitory block (aCSF + 100 nM gabazine, gzn), without changing any other parameter (i.e. same stimulation location and intensity). …”