Investigating the Causal Relationship of C-Reactive Protein with 32 Complex Somatic and Psychiatric Outcomes: A Large-Scale Cross-Consortium Mendelian Randomization Study by Bram. P. Prins (3165489)

“…Further, we found that a standardized CRP polygenic risk score (CRP_<i>PRS</i>) at <i>p-</i>value thresholds of 1 × 10⁻⁴, 0.001, 0.01, 0.05, and 0.1 using individual-level data also showed a protective effect (OR < 1.00) against schizophrenia; the first CRP_<i>PRS</i> (built of SNPs with <i>p</i> < 1 × 10⁻⁴) showed a statistically significant (<i>p <</i> 2.45 × 10⁻⁴) protective effect with an OR of 0.97 (95% CI 0.95–0.99). …”

MAP3K19 siRNA inhibits cigarette smoke-induced pulmonary inflammation. by Stefen A. Boehme (2657068)

“…<p>The acute model of cigarette smoke exposure subjected mice to cigarette smoke (7 cigarettes over a 1.75 hour period) on days 1 & 2, and dosed with either PBS, non-sense siRNA (100 μg in 50 μl volume), MAP3K19 siRNA or the CXCR-2 antagonist SB 265610 (10 mg/kg, p.o.) on days 1, 2 & 3 (n = 5 mice per treatment group). …”

RNA-Seq Profiling of a Defective Seed Coat Mutation in <i>Glycine max</i> Reveals Differential Expression of Proline-Rich and Other Cell Wall Protein Transcripts by Anupreet Kour (564197)

“…<div><p>The plant cell wall performs a number of essential functions including providing shape to many different cell types and serving as a defense against potential pathogens. …”

Neoadjuvant letrozole for postmenopausal estrogen receptor-positive, HER2-negative breast cancer patients, a study from the Danish Breast Cancer Cooperative Group (DBCG) by Signe Korsgaard Skriver (4613635)

“…Here, we report the results obtained by neoadjuvant letrozole in patients with early breast cancer in a phase-II design.…”

Assessing the usage of end-of-life tire pyrolysis oil as an alternative fuel in a diesel engine in the point of energy, exergy, exergoeconomic, exergoenviroeconomic, and sustainabi... by Talha Ertürk (19715855)

“…<p>The present study examines the utilization of fuel blends comprising waste tire pyrolysis oil (WTPO) at varying ratios (10%, 20%, 30%, and 40%) in a compression-ignition (CI) engine at different loads (25%, 50%, 75%, and 100%). …”

ERR2/3 may in part operate through <i>Kcna10</i> to promote a gamma motor neuron-like biophysical signature. by Mudassar N. Khan (14290428)

“…<b>(C)</b> Reporter tdTomato fluorescence driven by wild-type (WT) <i>Kcna10</i> promoter is boosted by ERR2 cotransfection (red, <i>n</i> = 102) in chick motor neurons when compared to control (gray, <i>n</i> = 100) and decrease in tdTomato reporter fluorescence upon mutating the ERR2/3 binding sites (black, <i>n</i> = 101). …”

Table 2_Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration.xlsx by Meng Yi (7853249)

“…</p>Results<p>Bioinformatics analysis of human data identified three diagnostic biomarkers (S100A12, IL1R1, FCGR2B) and constructed a robust ANN diagnostic model (AUCs: 0.744-0.868). …”

Presentation_1_Altered Lipid Metabolism Impairs Skeletal Muscle Force in Young Rats Submitted to a Short-Term High-Fat Diet.PPTX by David E. Andrich (5791211)

“…Young male Wistar rats (100–125 g) were fed HFD or a regular chow diet (RCD) for 14 days. …”

Table_1_Altered Lipid Metabolism Impairs Skeletal Muscle Force in Young Rats Submitted to a Short-Term High-Fat Diet.DOCX by David E. Andrich (5791211)

“…Young male Wistar rats (100–125 g) were fed HFD or a regular chow diet (RCD) for 14 days. …”

Table 4_Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration.xlsx by Meng Yi (7853249)

“…</p>Results<p>Bioinformatics analysis of human data identified three diagnostic biomarkers (S100A12, IL1R1, FCGR2B) and constructed a robust ANN diagnostic model (AUCs: 0.744-0.868). …”

Table 3_Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration.xlsx by Meng Yi (7853249)

“…</p>Results<p>Bioinformatics analysis of human data identified three diagnostic biomarkers (S100A12, IL1R1, FCGR2B) and constructed a robust ANN diagnostic model (AUCs: 0.744-0.868). …”

Table 1_Multi-omics analysis and evidence of IL1R1 as a potential biomarker for diabetes-associated intervertebral disc degeneration.xlsx by Meng Yi (7853249)

“…</p>Results<p>Bioinformatics analysis of human data identified three diagnostic biomarkers (S100A12, IL1R1, FCGR2B) and constructed a robust ANN diagnostic model (AUCs: 0.744-0.868). …”

PrP^CGPIThy-1 L150 mice show a delay to terminal disease and altered neuropathology upon prion infection. by Berta Puig (344828)

“…Chart underneath shows mean relative intensity of PrP referred to actin where WTPrP^C samples are set to 100% as a reference (error bars are SEM; n = 5 for each genotype). …”

Table_1_Association between sedentary behavior, physical activity, and cardiovascular disease-related outcomes in adults—A meta-analysis and systematic review.DOCX by Zhi-de Liang (13980063)

“…The study quality was rated as low to moderate. We found an increased hazard ratio (HR) for CVD in the population with SB (HR = 1.34; 95% confidence interval [CI]: 1.26 to 1.43; I² = 52.3%; P_{heterogeneity} < 0.001, random model) and a decreased HR for CVD in those who performed long-term PA (HR = 0.71; 95% CI: 0.66 to 0.77; I² = 78.0%, P_{heterogeneity} < 0.001, random model). …”

Table_1_Association between sedentary behavior, physical activity, and cardiovascular disease-related outcomes in adults—A meta-analysis and systematic review.DOCX by Zhi-de Liang (13980063)

“…The study quality was rated as low to moderate. We found an increased hazard ratio (HR) for CVD in the population with SB (HR = 1.34; 95% confidence interval [CI]: 1.26 to 1.43; I² = 52.3%; P_{heterogeneity} < 0.001, random model) and a decreased HR for CVD in those who performed long-term PA (HR = 0.71; 95% CI: 0.66 to 0.77; I² = 78.0%, P_{heterogeneity} < 0.001, random model). …”

Phylogenetic Impoverishment of Amazonian Tree Communities in an Experimentally Fragmented Forest Landscape by Bráulio A. Santos (242306)

“…Consistent with this loss in phylogenetic diversity, we observed a significant decrease of 50% in phylogenetic dispersion since forest isolation, irrespective of plot location. …”

Data_Sheet_1_Metabolic folate profiling as a function of time during cultivation suggests potential C2-metabolism in Saccharomyces cerevisiae.docx by Lena Schillert (13979652)

“…Highest folate contents of 13,120 μg/100 g were observed after 20 h of cultivation. The main vitamers 5-CH₃-H₄folate and H₄folate decreased during cultivation, while 5-CHO-H₄folate increased during cultivation. …”

Data Sheet 1_Burden of stroke in the United States of America, 1990–2021: a systematic analysis for the US burden of disease study 2021.pdf by Jung-Hyun Park (531735)

“…Although age-standardized incidence and mortality rates generally decreased over this period, the incidence of SAH has increased recently, and hemorrhagic stroke mortality peaked around 2000. …”

Effect of Selenite and Selenate Application on Mineral Composition of Lettuce Plants Cultivated Under Hydroponic Conditions: Nutritional Balance Overview Using a Multifaceted Study by Emanueli do Nascimento da Silva (3897079)

“…Selenate promoted the absorption of Mo and S and the reduction of K, Mn and P, meanwhile selenite increased Mn and decreased Mo accumulation. Copper and Fe absorption was negatively affected, Ca and Mg showed a slight increase, and Na and Zn were not affected by Se species. …”

Table_1_Effect of Late Testing and Antiretroviral Treatment on Mortality Among People Living With HIV in the Era of Treat-All in Guangdong Province, China, 1992–2018: A Cohort Stud... by Qiaosen Chen (9324631)

“…The all-cause mortality saw a decreasing trend from 1.46 cases/100 person-year in January 2009 to 0.14 cases/100 person-year in December 2018 (standardized rate). …”