datasheet1_In Vitro, In Vivo and In Silico Effectiveness of LASSBio-1386, an N-Acyl Hydrazone Derivative Phosphodiesterase-4 Inhibitor, Against Leishmania amazonensis.docx by Dahara Keyse Carvalho Silva (9774635)

“…In vitro incubation with LASSBio-1386 reduced the percentage of Leishmania-infected macrophages and the number of intracellular parasites (EC₅₀ = 9.42 ± 0.64 µM). Also, in vivo treatment of BALB/c mice infected with L. amazonensis resulted in a decrease of lesion size, parasitic load and caused histopathological alterations, when compared to vehicle-treated control. …”

MK-2206 induced cytotoxicity, inhibited proliferation and was able to overcome the protective effects of the tumor microenvironment. by Vijay Ramakrishnan (117159)

“…<p>When we cultured MM cell lines with indicated concentrations of MK-2206 for 48 hrs we observed dose dependent decrease in <b>A)</b> viability as observed by MTT assays and <b>B)</b> tritiated thymidine uptake indicative of inhibition of proliferation albeit with differences in the sensitivity of cell lines to MK-2206. …”

Effects of FAK inhibitor Y15 during ovulation <i>in vivo</i>. by Hiroya Kitasaka (4840218)

Extrinsic fluorescence ANS (1-Anilino-8-Naphthalin Sulfonate) fluorescence spectroscopy of Caldendrin and L- and S-CaBP1. by Pasham Parameshwar Reddy (603740)

“…Titration with Mg²⁺ results in a significant decrease in the fluorescence intensity, whereas Ca²⁺ titration to Mg²⁺ bound S-CaBP1 reversed this effect. …”

MTM inhibits proliferation, migration and invasion of endothelial cell lines STR4 and STR10. by Eléonore Otjacques (410361)

“…(<b>A</b>) Increasing concentrations of MTM resulted in a minor anti-proliferative effect in STR-4 cells, while MTM inhibited STR-10 proliferation with an IC-50 of 200 nM. …”

Methylation of cholinergic genes in neuronal SH-SY5Y cells after stimulation (n = 3). by Caroline Holtkamp (6751754)

“…(<b>b</b>) The artificial de-methylation of the epigenome of SH-SY5Y cells using 5-aza-2’ deoxycytidine (ADC, 50 μM) resulted in a visible decrease of overall methylation as measured in the three promoter regions. …”

Loss of <i>Hes1</i> impairs neural crest development. by Francesca Rochais (371680)

“…<p>(A) In situ hybridization at E9.5 showing decreased <i>Crabp1</i> transcript accumulation in the caudal pharyngeal region of <i>Hes1</i>^−/− compared to <i>Hes1</i>^+/+ embryos (arrowheads). …”

Fig 3 - by Sujata Srikanth (6417701)

“…The yellow area represents the overlap between the control and the sample, pink represents the underutilization of the substrate by the sample and green represents the overutilization of the substrate by the sample. <b>(c) Bar chart representing an increase or decrease in utilization of selected compounds on Biolog plates for each individual with PMS.…”

Data_Sheet_3_The Effect of Allicin on the Proteome of SARS-CoV-2 Infected Calu-3 Cells.XLSX by Kirstin Mösbauer (5782847)

DataSheet_1_The distribution and emission of CO2, CH4 and light hydrocarbons in an anticyclonic eddy of the Kuroshio extension.docx by Xiao-Jun Li (1718128)

Optimization of TEV protease cleavage conditions. by Yu-Fu Hung (513472)

“…(C) Binding properties of GST-GB1-NS4A(1–48) to GSH sepharose in the presence of urea. …”

Paired t-test comparing standard levels measured on recruitment and at follow-up. by Cherith N. Reid (291365)

Proteome Response of <em>Tribolium castaneum</em> Larvae to <em>Bacillus thuringiensis</em> Toxin Producing Strains by Estefanía Contreras (277268)

“…The protein displayed amino acid sequence and structural homology to <em>Tenebrio molitor</em> 12 kDa hemolymph protein b precursor, a non-olfactory odorant binding protein. Analysis of mRNA expression and mortality assays in Odorant binding protein C12 silenced larvae were consistent with a general immune defense function of non-olfactory odorant binding proteins. …”

Vasorelaxation of small arteries (<150 µm) from 9 month-old GK or Wistar rats is endothelia dependent. by Sachin Gupte (363123)

Data_Sheet_1_KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration.PDF by Mladen Paradžik (8522163)

Table_2_KANK2 Links αVβ5 Focal Adhesions to Microtubules and Regulates Sensitivity to Microtubule Poisons and Cell Migration.xlsx by Mladen Paradžik (8522163)

Pnc1 activity in CUG mistranslating cells. by Raquel M. Silva (223505)

“…The region of the ¹H spectra containing the H6 protons of NAM (8.50 ppm) and of NAC (8.40 ppm) shows the conversion of NAM to NAC via a decrease in the area of the resonance from the H6 proton of NAM and a concurrent increase in the area of the resonance at 8.40 ppm from the H6 proton of NAC. …”

CBE and isofagomine effectively inhibit purified GBA1 at 1 mM and 1 μM, respectively. by Zdenek Berger (440685)

“…The graph shows a summary of three independent experiments. E) Addition of sodium taurocholate (NaTc) increases activity of GBA1 ~ 5-fold but decreases activity of GBA3 by ~ 50%. …”

Cytotoxicity of candidate agents to cholangiocarcinoma cells. by Chiara Braconi (235041)

“…All three compounds decreased cell viability in a concentration-dependent manner, with an IC50 for felodipine of 26±5 µM, nitrendipine, 44±10 µM and nifedipine, 15±4 µM. …”

Force-frequency relationship in zebrafish ventricular myocardium. by Moritz Haustein (734263)