Kinases are recruited to the signaling complex by alternative N-t localization domains. by Paloma M. Sato (672126)

“…In most cases, mutations that disrupt specific recruitment interactions decrease pathway activation between 40%–50%. MUT Ste20[N]-Ste50[C] might still localize to the signaling complex, as Ste50's RA domain binds Cdc42 independently of Ste20's PBD domain <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.1002012#pbio.1002012-Truckses1" target="_blank">[53]</a>. …”

Effect of SARS-CoV-2 Infection and Infection Severity on Longer-Term Glycemic Control and Weight in People With Type 2 Diabetes by Rachel Wong (5544899)

Response gain control by ACh. by Shogo Soma (429657)

“…Gray circles indicate facilitated and suppressed cells whose C₅₀ were decreased or increased by more than 1 SD from the population average, respectively (C, facilitated cells, <i>n</i> = 4; D, suppressed cells, <i>n</i> = 7). …”

Effect of NK depletion on IFN-γ production in tripartite cultures. by Loke Tim Khaw (433343)

Effect of endothelial cells on cytokine production in PBMC/iRBC co-cultures. by Loke Tim Khaw (433343)

MPA and tacrolimus act differentially on the polarization of M1 and M2 macrophages. by Nynke M. Kannegieter (3697594)

“…Tacrolimus changed the expression of M2 markers under a M1-driven condition and decreases the expression of M1 markers under M2 conditions. …”

Tau overload causes behavioral deficits and maintains neurodegeneration at older ages. by Kaushik Ghosal (244754)

“…<p>A. hTau animals also showed decreased working memory as measured by deficits in spontaneous alternations compared to age-matched wild-type animals. …”

Data_Sheet_1_Immediate and long-term electrophysiological biomarkers of antidepressant-like behavioral effects after subanesthetic ketamine and medial prefrontal cortex deep brain... by Matthew Bergosh (18854590)

“…</p>Results<p>We found that the depression-like behavioral and weight effects of CORT correlated with a decrease in aperiodic-adjusted theta power (5–10 Hz) and an increase in sample entropy during the administration phase, and an increase in theta peak frequency and a decrease in the aperiodic exponent once the depression-like phenotype had been induced. …”

Weight gain was associated with worsening glycemia and cardiovascular and kidney outcomes in type 2 diabetes patients independent of diabetes medication in the GRADE Randomized Con... by Deborah J. Wexler (492527)

MEKi inhibits growth and ablates MAPK regardless of <i>PIK3CA</i>^<i>mut</i> status. by Robert S. McNeill (5485064)

“…<p>Selumetinib IC₅₀ were similar regardless of <i>PIK3CA</i>^<i>mut</i> status in NHA (<b>A</b>), but slightly higher in most <i>PIK3CA</i>^<i>mut</i> NHA^RAS compared to parental cells (*, P≤0.03) (<b>B</b>) (<b><a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0200014#pone.0200014.s011" target="_blank">S11 Fig</a></b>). …”

SC-1 Inhibited RSK2 Kinase Activity <i>in vitro</i> and an RSK2 Inhibitor Increased Colony Formation. by Susan D. Mertins (380936)

“…<p>COLO 205 tumor cell line was treated with SL0101 (1.25 µM) and SC-1 (0.1 µM) for 24 hrs prior to soft agar cloning, lysate preparation, and immunoblotting. A. SC-1 inhibited RSK2 N-terminal domain <i>in vitro</i> kinase activity with an EC₅₀ of 2.5±1.8 µM (mean±SD, n = 5) but not in other like assays for Aurora kinase B, CHK1, or CHK2 kinases. …”

SS inhibits breast cancer growth <i>in vivo</i>. by Zhiyu Wang (282312)

“…The results indicated that LDH-A expression in both SS-treated breast cancer xenografts were significantly reduced, while TUNEL analysis indicated that the apoptosis ratio in SS –treated tumor samples was significantly increased. (×100, scale bar = 50 um; All values represents as Mean±SD, n = 6, *<i>P</i><0.05 <i>vs.…”

Table 1_Role of seed priming using natural biostimulants in reducing salt stress effects by reshaping physio-biochemical and antioxidant defense systems in glycine max seedlings.do... by Mostafa M. Rady (14004633)

“…<p>Abiotic stress significantly damages crops, reducing global yields by over 50%. Among these challenges, salt stress poses a critical constraint that severely affects the growth, productivity, and quality of soybeans in various regions worldwide. …”

Changes in human intervertebral disc biochemical composition and bony end plates between middle and old age by Delio Eulalio Martins (5759282)

“…</p><p>Results</p><p>The old-aged group showed a decrease in content of sulphated and non-sulphated glycosaminoglycans relative to middle-aged and there were also alterations in the proportion of GAG disaccharides and a decrease of collagen fiber size. …”

Donor and Geometry Optimization: Fresh Perspectives for the Design of Polyoxometalate Charge Transfer Chromophores by Bethany R. Hood (20396768)

Brivanib inhibits liver fibrosis induced by thioacetamide. by Ikuo Nakamura (548298)

“…(B) The number of bands of bridging fibrosis per high power field were counted in images obtained at 100× magnification after Sirius red staining. There was a significant decrease in the number of bands in both the 25 mg/kg and 50 mg/kg brivanib groups, compared to placebo. …”

Collagen XVI overexpression leads to an increase of ILK/kindlin-1 interaction. by Konstanze B. Bedal (513309)

“…<p>(<b>A</b>) Proximity ligation assay for the analysis of ILK/kindlin-1 interaction in COLXVI and mock control cells (scale bar equals 50 µm). …”

Influence of Experimental Thermal Shifts and Overcrowding on Fecundity in Wild Females of Acartia Tonsa of the Bahía Blanca Estuary by Berasategui Anabela Anahi (10476259)

“…We examined the influence of thermal shift (6 ± 1ºC and 18 ± 1ºC) and overcrowding stress on egg production and hatching success in wild females of A. tonsa of the Bahía Blanca Estuary. Egg production rate (EP), hatching success during seven days (E7 %) and time taken to hatch 50 % of eggs (T 50) were registered. …”

The effect of dopamine on Δψ_m and [Ca²⁺]_c in midbrain neurons and astrocytes. by Sonia Gandhi (49260)

“…Furthermore this increase in [Ca²⁺]_c is associated with a reduction in ΔΨ_m. Application of 50 mM KCl induces a further rise in [Ca²⁺]_c and profound mitochondrial depolarisation. …”

How Stable Are 2H-MoS₂ Edges under Hydrogen Evolution Reaction Conditions? by Nawras Abidi (9089558)

“…Hence, we suggest that the 50%S S-edge evolves over time toward a 0%S S-edge, covered by surface OH that will block permanently the active sites.…”