HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

Primer pairs for RT-qPCR. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Global Projections of 21^st Century Land-Use Changes in Regions Adjacent to Protected Areas by Linda J. Beaumont (140436)

“…For five periods across the 21^st century, we assessed changes to the extent of primary land, secondary land, pasture and crop land projected to occur within 50 km buffers surrounding IUCN-designated PAs. …”

Data_Sheet_1_Chicken Manure and Mushroom Residues Affect Soil Bacterial Community Structure but Not the Bacterial Resistome When Applied at the Same Rate of Nitrogen for 3 Years.do... by Shuang Peng (1409656)

“…A total of 262 ARG subtypes were detected in chicken manure using high-throughput qPCR, and heat treatment can effectively remove 50 types of ARGs. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

HDAC7 Inhibition by Phenacetyl and Phenylbenzoyl Hydroxamates by Jeffrey Y. W. Mak (10132069)

“…The zinc-containing histone deacetylase enzyme HDAC7 is emerging as an important regulator of immunometabolism and cancer. Here, we exploit a cavity in HDAC7, filled by Tyr303 in HDAC1, to derive new inhibitors. …”

RT-qPCR data tables. by Yoichi Kurokawa (22290520)

“…Conversely, exposure to endogenous prooxidants (dopamine and adrenaline), certain food-derived polyphenols (chrysin and 3-<i><i>O</i></i>-methylquercetin), or 1,2-naphthoquinone led to a significant decrease (<0.5-fold) in Rmst expression. …”

Emergent oscillations in population activity. by Kwangjun Lee (22226994)

Data_Sheet_1_Acidification and hypoxia drive physiological trade-offs in oysters and partial loss of nutrient cycling capacity in oyster holobiont.PDF by Deevesh Ashley Hemraj (15775310)

“…Microbes also seemed to have lost some capacity in nutrient cycling under hypoxia and multi-stressor conditions (~50% less nitrification) but not acidification.</p>Discussion<p>We show that the microbiota associated to the oyster can be enriched differently under climate change depending on the type of environmental change that the oyster holobiont is exposed to. …”

Results of mechanical analysis of SA and PLGA MN. by Yusuf K. Demir (475556)

“…MN failure was interpreted as the sudden decrease in force. (B) Mechanical analysis of polymeric PLGA (50∶50) MNs under axial loading. …”

Managing Impending Non-Severe Hypoglycemia with Oral Carbohydrates in Type 1 Diabetes: The REVERSIBLE Trial. by Ran Cheng (8449275)

“…Following inpatient subcutaneous insulin-induced decrease in BG in the fasting state, 16g of oral CHO was administered at a plasma glucose (PG) of <70 mg/dL (3.9 mmol/L), ≤80 mg/dL (4.5 mmol/L) or ≤90 mg/dL (5.0 mmol/L). …”

Table_1_Exogenous γ-aminobutyric acid (GABA) mitigated salinity-induced impairments in mungbean plants by regulating their nitrogen metabolism and antioxidant potential.docx by Abd Ullah (6529958)

“…In leaves, salinity caused a significant increase in Na+ concentration but a decrease inK+ concentration, resulting in a low K+/Na+ concentration (51- and 71% under 50- and 100- mMstress). …”

Table_1_Exogenous γ-aminobutyric acid (GABA) mitigated salinity-induced impairments in mungbean plants by regulating their nitrogen metabolism and antioxidant potential.docx by Abd Ullah (6529958)

“…In leaves, salinity caused a significant increase in Na+ concentration but a decrease inK+ concentration, resulting in a low K+/Na+ concentration (51- and 71% under 50- and 100- mMstress). …”

datasheet1_COVID-19 Incidence in Patients With Immunomediated Inflammatory Diseases: Influence of Immunosuppressant Treatments.docx by Natalia Soldevila-Domenech (9903768)

“…Our results report a decreased incidence of COVID-19 in patients receiving specific DMARDs with different immunodepressor mechanisms with striking sex differences. …”

DataSheet1_Antisense targeting of FOXP3+ Tregs to boost anti-tumor immunity.docx by Tatiana Akimova (345316)

“…Isolated human Treg, incubated with ASO FOXP3 for 3.5 hours, had significantly impaired suppressive function (66.4%) versus Scramble control. In murine studies, we observed a significant inhibition of tumor growth, while 13.6% (MC38) to 22% (TC1) of tumors were completely resorbed, in conjunction with ~50% decrease of Foxp3 mRNA by qPCR and decreased numbers of intratumoral Tregs. …”

C/EBPβ-Thr217 Phosphorylation Signaling Contributes to the Development of Lung Injury and Fibrosis in Mice by Martina Buck (82941)

DataSheet_1_Non-steroidal anti-inflammatory drugs and clinical outcomes in patients with COVID-19.docx by Jing Zhang (23775)

Table_1_Developmental Pharmacokinetics and Safety of Ibuprofen and Its Enantiomers in the Conventional Pig as Potential Pediatric Animal Model.DOCX by Joske Millecam (5214191)

Image 1_Danggui Shaoyao San ameliorates Alzheimer’s disease by regulating lipid metabolism and inhibiting neuronal ferroptosis through the AMPK/Sp1/ACSL4 signaling pathway.tif by Kai Gong (381355)