DataSheet1_Exploring pyrrolidinyl-spirooxindole natural products as promising platforms for the synthesis of novel spirooxindoles as EGFR/CDK2 inhibitors for halting breast cancer... by Mohamed S. Nafie (9754305)

“…<p>Cancer represents a global challenge, and the pursuit of developing new cancer treatments that are potent, safe, less prone to drug resistance, and associated with fewer side effects poses a significant challenge in cancer research and drug discovery. …”

Generation of mu opioid receptor conditional knockout mice. by Raphaël Weibel (458030)

“…<p>(<b>A</b>) The conditional <i>Oprm1</i> (<i>Oprm1</i>^fl) allele was created by homologous recombination. …”

Calcium overloading upregulates RCAN1 isoform 4 expression through activation of NFAT signaling pathway. by Xiulian Sun (573264)

“…<p>(<b>A</b>) Calcium ionophore A23187 increased <i>RCAN1</i> isoform 4 mRNA expression in HEK293 cells. …”

<i>Otx2</i> requires <i>Lmx1b</i> for the development of mdDA neurons. by Orna Sherf (804524)

“…<p>Representative coronal midbrain section of E12.5 WT (A-B, K-L), <i>En1</i>^+/Otx2(C-D, M-N), <i>Lmx1b</i>^<i>-/-</i> (E-F, O-P) and <i>En1</i>^+/Otx2; <i>Lmx1b</i>^<i>-/-</i> (G-H, Q-R) embryos. …”

Table_1_Practical Model to Optimize the Strategy of Adjuvant Postmastectomy Radiotherapy in T1-2N1 Breast Cancer With Modern Systemic Therapy.docx by Fei-Fei Xu (538090)

“…After a median follow-up of 69 months, the 5-year rate of DFS, BCSS, and LRR in the overall cohort was 90.2%, 97.4%, and 3.6%, respectively. …”

The effect of the PI3K inhibitor LY294002 (LY) on the cell viability and the [Ca²⁺]_i of primary cultured SD rat retinal cells in H₂O₂ in... by Yan Feng (128912)

“…<p>A: Western blot results of the activation of the PI3K/Akt pathway after βE2 treatment for 0.5 hrs; B: Quantitative data of A; C, E, G, and I: Cell viability quantitative data; D, F, H, and J: [Ca²⁺]_i quantitative data; C and D: The effects of LY treatments for 24 hrs and 0.5 hrs on the cell viability and the resting [Ca²⁺]_i; E and F: The inhibitory effect of LY pretreatment for 0.5 hrs on the increased cell viability and [Ca²⁺]_i induced by 10 μM βE2 treatment for 0.5 hrs (10 μM LY in E, 10 μM and 20 μM LY in F); G and H: The effect of LY pretreatment for 0.5 hrs on the decreased cell viability and increased [Ca²⁺]_i induced by 100 μM H₂O₂ treatment for 2 hrs (10 μM LY in G, 10 μM and 20 μM LY in H); I and J: The dose-dependent attenuating impact of 20-50 μM LY pretreatment for 0.5 hrs on the βE2 retinal protective role against H₂O₂ injury, which is associated with the dose-dependent attenuation of the increased [Ca²⁺]_i (Protocol of drug application: LY for 0.5 hrs, E2 for 0.5 hrs and H₂O₂ for 2 hrs). …”

Taqman qPCR assays of retrohoming in notable <i>E. coli</i> mutants. by Jun Yao (9646)

“…</p>†<p>Genes in which mutations decreased retrohoming frequencies in published genetic screens <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003469#pgen.1003469-Smith1" target="_blank">[12]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003469#pgen.1003469-Coros1" target="_blank">[22]</a>, <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1003469#pgen.1003469-Beauregard1" target="_blank">[30]</a>.…”

Defective eviction of nucleosomes surrounding 5’ Gcn4 motifs in SWI/SNF and RSC mutants. by Yashpal Rawal (606804)

“…<b>(C-E)</b> Notched box plots for the 3 sets of 5’ sites defined in <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010277#pgen.1010277.g002" target="_blank">Fig 2A and 2B</a> and indicated again in (B), depicting (C) H3 occupancies per base pair in the ±100 bp windows surrounding the Gcn4 motifs, (D) log₂ Gcn4 occupancies taken from <a href="http://www.plosgenetics.org/article/info:doi/10.1371/journal.pgen.1010277#pgen.1010277.g002" target="_blank">Fig 2C</a>, and (E) log₂ Rpb3 occupancies averaged over the CDS of genes with 5’ sites. …”

PolyQ expansion affects p53-dependent apoptotic function in cells and in zebrafish. by Hongmei Liu (129385)

“…Underlying data are shown in <a href="http://www.plosbiology.org/article/info:doi/10.1371/journal.pbio.2000733#pbio.2000733.s008" target="_blank">S1 Data</a>. …”

Characterizing the connectivity of in vitro neuronal networks. by Christian Donner (3663007)

“…<p><b>A</b> Firing rate cumulative density function (CDF) of 600 spike-sorted units from HD-MEA recordings obtained from primary cortical cultures (top panel; n = 6 cultures; 100 units per network; recording duration: 1 h; culture age: DIV 14); and CDF of inter-spike interval coefficients of variation (ISI CV) for the same cultures (lower panel). …”

Activity and Reactivity of Fe²⁺ Cations in the Zeolite. Ab Initio Free-Energy MD Calculation of the N₂O Dissociation over Iron-Exchanged Ferrierite by Lubomir Benco (1987384)

“…The MD simulations show that the bivalent Fe²⁺ cation can induce a local deformation of the zeolite framework, which cannot be observed experimentally. …”

Table 1_Vitamin D3 promotes white fat beige through IL-27/P38MAPK/PGC-1α pathway.docx by Yanqiu Zhou (2172931)

“…After VD₃ intervention, TC, TG, and the number of LDs were significantly reduced in both HFD rats and 3T3-L1 cells, and serum IL-6 and MCP-1 in HFD rats were decreased. Meanwhile, there was a significant increase in mRNA and protein expression for VDR, IL-27R, P38MAPK, and PGC-1α. …”

Influence of main factors (enrichment, sex, cohort) on mean of parameters in 2 mouse strains. by Viola André (5104808)

“…The intercept is the mean of the parameter of the reference group and is set as 100%. Grey shade: variable selection using the BIC yielded nonrelevant influencing factor, thus no effect can be assumed; violet shade: factor is relevant for the model, i.e., mean is increased compared to reference group; yellow shade: factor is relevant for the model, i.e., mean is decreased compared to reference group; strength of color reflects size of difference. …”

<i>C</i>. <i>elegans</i> SNX-3 is required for formation of clathrin-independent recycling endosomal tubules. by Yangli Tian (4871416)

“…<p>(A) Confocal images provide the effect of various SNX mutant or RNAi treatment on the subplasmalemmal hTAC-GFP-containing tubular endosomes. …”

FGF inhibitor and six additional compounds that impair nerve regeneration after fin removal also impair regeneration after laser nerve transection. by Juliane Bremer (161529)

“…However, following laser nerve transection in both DMSO and 10-HCT treated larvae, the number of neurons decreased on average by 3 neurons, suggesting that a subset of neurons with transected axons died.…”

dAtx2 Levels Modulate Ataxin-1[82Q]-Induced Eye Neurotoxicity by Ismael Al-Ramahi (85012)

“…(A–E) SEM scale bar=100μm. (A′–E′) are 30μm X 30μm. …”

JAK/STAT signaling promotes high global translation rates in CySCs. by Ruoxu Wang (9312306)

“…Asterisks mark the hub. (C, C′) A wild-type testis showing highest OPP in CySCs adjacent to the hub and decreasing OPP levels with increasing distance from the hub. …”

PrP^Sc accumulation in <i>TNFR1^−/−</i> lymph nodes requires LTβR signaling independent of <i>Prnp</i> expression. by Tracy O'Connor (143972)

“…Histoblots were performed on frozen sections from spleens (SPL; A–D) or mesenteric lymph nodes (mLN; E–H) from mice in each treatment group to visualize PrP^Sc deposition. …”

Upon depletion of corneal conventional dendritic cells, virus titers and the local corneal damages are significantly increased in primary herpes simplex keratitis. by Kai Hu (311882)

“…Data are shown as mean ± SD. Scale bar: 100 μm.</p>…”

The pathway of ADF7-inhibited-VLN1 is involved in osmotic-induced F-actin depolymerization and ROS accumulation. by Shuangtian Bi (5183459)

“…<p><b>(A)</b> Confocal microscopy images of epidermal cells visualized by the expression of <i>fABD2</i>::<i>GFP</i> in root apices from Col-0 seedlings under mannitol treatments (200 mM) for 0, 3, 6, and 9 h. …”