Extinction on biophysical fitness landscape. by C. Scott Wylie (145239)

“…<p>All finite populations eventually go extinct. The mean number of generations until extinction (<i>τ</i>) increases with population capacity (<i>N</i>) and decreases with mutation rate (<i>U</i>). …”

Effects of Synthetic N-Terminal 17-Residue Peptide on the Δ2–17 MthK Channels by Mario Meng-Chiang Kuo (376172)

“…<div><p>(A) A single-channel trace (top) shows that the channel open probability decreases when 10 μM synthetic peptide (aa1–17) was added to the perfusate (red bar). …”

Effects of BT on gastrointestinal motility. by Wei-Yi Wu (1785187)

“…S, Stomach; A, appendix. Only 5 BT decreased gastrointestinal transit. …”

Effects of TO901317 on apoptosis. by Irene Paterniti (310894)

“…<p>The results underlined that Bax expression was considerably enhanced in the MPTP group (b, b1 see densitometry analysis g, and Figure b in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174470#pone.0174470.s005" target="_blank">S5 File</a>) whereas treatment with TO901317 significantly limited the rise in Bax expression (c,c1 see densitometry analysis g and Figure c in <a href="http://www.plosone.org/article/info:doi/10.1371/journal.pone.0174470#pone.0174470.s005" target="_blank">S5 File</a>). …”

Table_1_Enhanced immune reconstitution with albuvirtide in HIV-infected immunological non-responders.docx by Lina Fan (2211169)

“…</p>Methods<p>In this prospective, open-label, controlled clinical study, participants with incomplete immune reconstitution (continuous ART over 5 years and CD4⁺T lymphocyte absolute count of <500 cells/µl or ART for 2–5 years and CD4⁺T cell count of <200 cells/µl with undetectable viral load) were received intensive treatment with ABT or maintained on the original ART regimen at a ratio of 1:1. …”

Figure 3 by Feng Bai (336697)

“…Thresholds were set at a corrected <i>P</i><0.05, determined by Monte Carlo simulation. (3) Overlap regions (PCC/Pcu) between baseline changes and longitudinal changes of DMN IC were observed in aMCI group compared to controls. (4) Hyper-functional connectivity between the PCC/PCu (overlap regions) and mean DMN IC in baseline aMCI subjects, and significant hypo-connections of these regions were in follow-up aMCI subjects, whilst controls only showed a light decreases at the longitudinal period. * <i>P</i><0.05 (0.046); ** <i>P</i><0.001(0.000). (5) Correlative analysis: within the aMCI group, the decreases of functional connectivity between PCC/PCu and mean DMN IC were positively related to the impairments of episodic memory (AVLT-delayed recall scores, r = 0.462, <i>P</i> = 0.018, two-tailed) from baseline to follow up. …”

La protein expression promotes proliferation and cell cycle progression of SCC 22B cells. by Gunhild Sommer (13580)

“…<p><b>(A)</b> Lower La expression in siRNA-mediated SCC 22B cells (see Western blot analysis in inlet) correlates with decreased proliferation rate (dotted line). …”

Efficacy of Topical Cyclosporine Combined with Punctal Plugs in Treating Dry Eye Disease and Inflammation by Changming Feng (19810956)

Whole Transcriptome Analysis of <i>Acinetobacter</i><i> baumannii</i> Assessed by RNA-Sequencing Reveals Different mRNA Expression Profiles in Biofilm Compared to Planktonic Cells by Soraya Rumbo-Feal (309518)

“…Disruption or deletion of five of these genes caused a significant decrease in biofilm formation ability in the corresponding mutant strains. …”

FIGURE 4 from HDAC6 Inhibition Releases HR23B to Activate Proteasomes, Expand the Tumor Immunopeptidome and Amplify T-cell Antimyeloma Activity by Priyanka S. Rana (15136410)

Catalase protein expression in DD fibroblasts. by Carina Jaekel (11146382)

“…<p>The expression of catalase in DD fibroblasts activated with TGF-β1 was significantly decreased on day 3(A). Blue light irradiation significantly decreased relative catalase expression in DD fibroblasts activated with TGF-β1 on day 3 and 5 (A, B). * p ≤ 0.05; ** p ≤ 0,005; *** p ≤ 0.0005. …”

Figshare20240613.pdf. Data obtained by American Heart Association Transformational Project Grant, 19TPA34850170.Update by Shinichi Oka (18824293)

“…The numbers of mice examined in each experimental group were: 6 (A), 6-7 (B), 7(C), 8 (D), 7 (acetyl lysine, E), 6-8 (acetyl-RelA at K310, E), 5 (acetyl lysine, F) and 6-8 (acetyl-RelA at K310, E). …”

Structural and Functional Models for the Dinuclear Copper Active Site in Catechol Oxidases:  Syntheses, X-ray Crystal Structures, Magnetic and Spectral Properties, and X-ray Absorp... by Frank Zippel (2971107)

“…These measurements reveal the reduction of Cu(II) to Cu(I) accompanied by a decrease of the coordination number.…”

Evolutionary history of deuterostome chromosome architectures. by Che-Yi Lin (218292)

“…<p>(<b>a</b>, <b>b</b>) A schematic representation of chromosome evolution in deuterostome lineages. …”

Silencing of Hdac4 and Ncor2 in 3T3-L1 adipocytes results in increased lipogenesis. by Tina Rönn (253292)

“…<p>CpG sites in the promoter region of A) <i>HDAC4</i> and B) <i>NCOR2</i> showed increased DNA methylation in response to exercise as well as decreased mRNA expression (C–D). …”

Clinical outcomes. by Yuta Seko (5703503)

“…We defined the weight loss as ≥ 5% decrease in body weight from discharge to 6-month index visit.…”

Data_Sheet_1_Multimodal Optical Imaging to Investigate Spatiotemporal Changes in Cerebrovascular Function in AUDA Treatment of Acute Ischemic Stroke.docx by Han-Lin Wang (8638884)

“…Moreover, at post-stroke day 3, increased functional vascular density was observed in AUDA-treated rats (35.9 ± 1.9% higher than that in the control group, p < 0.05). At post-stroke day 7, a 105.4% ± 16.4% increase of astrocytes (p < 0.01), 30.0 ± 10.9% increase of neurons (p < 0.01), and 65.5 ± 15.0% decrease of microglia (p < 0.01) were observed in the penumbra region in AUDA-treated rats (N = 5 for each group). …”

Extensive Natural Variation for Cellular Hydrogen Peroxide Release Is Genetically Controlled by Homa Attar (138799)

“…We did not find replication of SNPs across all cohorts, but replication within the same genomic region. Finally, a highly significant decrease in H₂O₂ release was observed in Down Syndrome (DS) individuals (p<2.88×10−12). …”

Data_Sheet_1_Variation of the BrO/SO2 Molar Ratio in the Plume of Tungurahua Volcano Between 2007 and 2017 and Its Relationship to Volcanic Activity.PDF by Simon Warnach (6901565)

“…For five phases, we additionally observe a progressive decrease to the initial values of 2 to 5 × 10⁻⁵ toward the end of the phase. …”

Sperm beat frequency and CA-activity in CA ^−/− mice. by Petra M. Wandernoth (149629)

“…Within the first 20 seconds after the addition of bicarbonate, the beat frequency of wild-type sperm (solid line) increases from 2.81±0.17 Hz to 6.13±0.35 Hz and frequency of CA IV^−/− sperm from 2.92±0.17 Hz to 5.57±0.18 Hz (<i>n</i> = 10). <b>C</b>, Sperm of CA IV^−/− mice show a decreased response to CO₂. …”